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Erschienen in:
01.03.2015 | Original Article
Effect of oral appliance on endothelial function in sleep apnea
Erschienen in: Clinical Oral Investigations | Ausgabe 2/2015
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Objectives
This study evaluated the effects of mandibular advancement device (MAD) on serum levels of nitric oxide derivatives and endothelial function by endothelium-dependent flow-mediated dilation (FMD) in obstructive sleep apnea syndrome (OSAS).
Methods
Thirty patients with moderately severe-to-severe OSAS who desired MAD and 15 healthy controls were prospectively enrolled. FMD was measured by high-resolution B-mode ultrasonography, while serum NO
x
level from peripheral blood samples was measured by ELISA. All subjects participated in the sleep studies, which were repeated 2 months after MAD in OSAS patients.
Results
Serum NO
x
level and FMD were lower in patients with OSAS than in controls prior to MAD. Serum NO
x
levels in 19 of 30 patients with OSAS, the designated MAD responders, increased from 11.8 ± 5.8 μM pre-MAD to 22.7 ± 4.9 μM post-MAD. The FMD increased from 5.9 ± 4.6 pre-MAD to 10.5 ± 4.8 post-MAD. For the 11 unresponsive patients, serum NO
x
and FMD remained impaired after MAD.
Conclusions
Successful treatment of OSAS with MAD can restore serum levels of NO
x
and FMD.
Clinical relevance
Endothelial function can be improved following effective treatment of OSAS using MAD.