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01.03.2024 | Research

Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial

verfasst von: Ana Joaquim, André Góis, Anabela Soares, Catarina Garcia, Anabela Amarelo, Pedro Antunes, Vera Afreixo, Vera Geraldes, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Helena B. Ferreira, Inês Guerra, Ana I. Afonso, M. Rosário Domingues, Luisa A. Helguero

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2024

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Abstract

Purpose

Physical exercise has positive effects on clinical outcomes of breast cancer survivors such as quality of life, fatigue, anxiety, depression, body mass index, and physical fitness. We aimed to study its impact on immune, inflammatory, cardiometabolic, and fatty acids (FA) biomarkers.

Methods

An exploratory sub-analysis of the MAMA_MOVE Gaia After Treatment trial (NCT04024280, registered July 18, 2019) was performed. Blood sample collections occurred during the control phase and at eight weeks of the intervention phase. Samples were subjected to complete leukocyte counts, cytokine, and cardiometabolic marker evaluation using flow cytometry, enzyme-linked immunoassays, and gas chromatography.

Results

Ninety-three percent of the 15 participants had body mass index ≥ 25 kg/m². We observed a decrease of the plasmatic saturated FA C20:0 [median difference − 0.08% (p = 0.048); mean difference − 0.1 (95%CI − 0.1, − 0.0)], positively associated with younger ages. A tendency to increase the saturated FA C18:0 and the ratio of unsaturated/saturated FA and a tendency to decrease neutrophils (within the normal range) and interferon-gamma were observed.

Conclusions

Positive trends of physical exercise on circulating immune cells, inflammatory cytokines, and plasmatic FA were observed. Larger studies will further elucidate the implications of physical exercise on metabolism. These exploratory findings may contribute to future hypothesis-driven research and contribute to meta-analyses.

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Titel: Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial
verfasst von: Ana Joaquim
André Góis
Anabela Soares
Catarina Garcia
Anabela Amarelo
Pedro Antunes
Vera Afreixo
Vera Geraldes
Andreia Capela
Sofia Viamonte
Alberto J. Alves
Helena B. Ferreira
Inês Guerra
Ana I. Afonso
M. Rosário Domingues
Luisa A. Helguero
Publikationsdatum: 01.03.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 3/2024
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-024-08365-x

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Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial