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17.04.2024 | Urology - Original Paper

Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial

verfasst von: Alireza Pakdel, Abdolreza Mohammadi, Hossein Chivaee, Amirreza Shamshirgaran, Hossein Amirzargar, Reza Mohammadi Farsani, Fardin Asgari, Alireza Khajavi, Seyed Mohammad Kazem Aghamir

Erschienen in: International Urology and Nephrology

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Abstract

Purpose

To investigate the effect of oral theophylline on stent-related syndrome (SRS) after Double-J insertion.

Background

Double-J stent is widely using in many urological procedures. Infection, hematuria, and discomfort are some of common complication after stenting. Theophylline is a dimethylated xanthine that inhibits phosphodiesterase and blocks adenosine receptors. To relaxing effect of theophylline on smooth muscles and its effects on the urinary system, it seems it could reduce complications after inserting Double-J stent especially ureteral stent syndrome.

Method

In this double-blind placebo-controlled randomized clinical trial, 67 patients were enrolled. Mean (SD) age of control and theophylline group was 51.8 (12.5) and 43.9 (10.4) years old, respectively. Patients were randomized into two groups of control and theophylline. All patients were stenting with silicon Double J. Theophylline group received 100 mg of theophylline, twice daily for 30 days, while control group received placebo. Stent symptoms were assessed by questionnaire and urine culture was performed before stent removal at removal day. Statistical analysis was performed using Chi-squared test and t test with P < 0.05 considered significant. Logistic regression models were fitted, crudely and adjusted for age and sex.

Result

Of 67 eligible patients, 60 completed the study. Theophylline significantly decreased percentages of gross hematuria (P < 0.001), dysuria (P < 0.001), and urinary frequency (P < 0.001). Microscopic hematuria (P = 0.042) and chills (P = 0.042) also decreased after theophylline.

Conclusion

Theophylline could be an effective and safe choice for reducing SRS among patients undergoing Double-J stent insertion.

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Titel: Effect of theophylline on stent-related symptoms in patients undergoing Double-J ureteral stent insertion: a randomized controlled trial
verfasst von: Alireza Pakdel
Abdolreza Mohammadi
Hossein Chivaee
Amirreza Shamshirgaran
Hossein Amirzargar
Reza Mohammadi Farsani
Fardin Asgari
Alireza Khajavi
Seyed Mohammad Kazem Aghamir
Publikationsdatum: 17.04.2024
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-024-04049-x

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