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Erschienen in:
09.12.2016 | Original Article
Effects of dose rate on early and late complications in low dose rate brachytherapy for mobile tongue carcinoma using 192Ir sources
Erschienen in: Oral Radiology | Ausgabe 3/2017
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Objectives
Low dose rate brachytherapy using 192Ir sources (LDR-BRT) is the definitive radiotherapy for early stage mobile tongue carcinoma. The effects of dose rate on early and late complications require re-evaluation, because the prescribed dose is almost fixed and a spacer has recently been used in all cases. Given this situation, we investigated any adverse effects of dose rate in LDR-BRT.
Methods
For this retrospective study, 116 patients with early tongue cancer treated with LDR-BRT alone at Tokyo Medical and Dental University Medical Hospital between 2008 and 2013 were enrolled. The patients were classified into two groups according to dose rate or biological effective dose. All patients had a spacer in place throughout the treatment period.
Results
The rates of overall survival, local control, and neck node metastasis did not differ significantly between the two groups. Notably, there were no significant differences in the severity or incidence of early or late complications between the two groups.
Conclusions
In the present study, we demonstrated that a dose rate of up to 0.91 Gy/h did not significantly influence the incidence of early or late complications when other factors were well controlled in the presence of a spacer.