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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 7/2017

30.12.2016 | Original Article

Effects of enamel matrix derivative on non-surgical management of peri-implant mucositis: a double-blind randomized clinical trial

verfasst von: Atabak Kashefimehr, Reza Pourabbas, Masumeh Faramarzi, Ali Zarandi, Abouzar Moradi, Howard C. Tenenbaum, Amir Azarpazhooh

Erschienen in: Clinical Oral Investigations | Ausgabe 7/2017

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Abstract

Background

Peri-implant diseases have been recognized as being among the ever-increasing complications related to dental implants. The aim of this study was to evaluate the adjunctive use of enamel matrix derivative (EMD) to mechanical debridement (MD) in patients with these conditions in terms of clinical parameters and cytokine levels of peri-implant crevicular fluid (PICF).

Methods

In the present double-blind clinical trial, 46 patients with peri-implant mucositis (PM) were randomly divided into control and test groups. Two different therapeutic protocols, consisting of non-surgical MD alone (control group) and MD with the application of EMD (test group), were considered for the two groups. Clinical parameters [bleeding on probing (BOP) and probing depth (PD)] and sampling from PICF were carried out before treatment and 3 months postoperatively. The levels of IL-6 and IL-17 cytokines in PICF were evaluated by enzyme-linked immunosorbent (ELISA).

Results

Three-month post-interventional assay revealed significant improvements in BOP and PD in the test group in comparison to the control group (P < 0.0001). Relative to control, IL-6 and IL-17 levels were reduced significantly (p < 0.05) in the test group compared to the control group.

Conclusion

Application of EMD can be considered an adjunct to MD in the non-surgical treatment of PM. However, complete recovery was not observed using either treatment approach showing that management of implant-associated disease is still a significant clinical problem.
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Fußnoten
1
Top Dent Lifco Dental AB, Enko¨ping, Sweden
 
2
Piezon ® 250, EMS Electro Medical Systems SA, Nyon, Switzerland
 
3
Air-Flow Master ®, Perio Powder ®; EMS Electro Medical Systems SA, Nyon, Switzerland
 
4
Laboratorios KIN, S.A., ,Barcelona, Spain
 
5
Emdogain ® Straumann, Basel, Switzerland
 
6
Laboratorios KIN, S.A., ,Barcelona, Spain
 
7
12 UNC color coded probe, Hu-Friedy Mfg. Co., LLC.Chicago, IL
 
8
Insight Dental Films, Eastman Kodak Company, Rochester, NY, USA
 
9
Periopaper ® Oraflow, Plainview, NY, USA
 
10
Eppendorf ® AG, Hamburg, Germany
 
11
PBS, Invitrogen, USA
 
12
Sigma-Aldrich, Saint Louis, MO, USA
 
13
MABTECH AB, R&D Systems, Büro Deutschland, Germany
 
Literatur
1.
Aljateeli M, Fu JH, Wang HL (2012) Managing peri-implant bone loss: current understanding. Clin Implant Dent Relat Res 14(Suppl 1):e109–e118CrossRefPubMed
2.
Algraffee H, Borumandi F, Cascarini L (2012) Peri-implantitis. Br J Oral Maxillofac Surg 50(8):689–694CrossRefPubMed
3.
Lindhe J, Meyle J (2008) Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35(8 Suppl):282–285CrossRefPubMed
4.
Atieh MA et al (2013) The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol 84(11):1586–1598PubMed
5.
Zitzmann NU, Berglundh T (2008) Definition and prevalence of peri-implant diseases. J Clin Periodontol 35(8 Suppl):286–291CrossRefPubMed
6.
Hultin M et al (2002) Microbiological findings and host response in patients with peri-implantitis. Clin Oral Implants Res 13(4):349–358CrossRefPubMed
7.
Van Dyke TE (2012) The impact of genotypes and immune reactivity on peri-implant inflammation: identification and therapeutic use of anti-inflammatory drugs and immunomodulators. Eur J Oral Implantol 5(Suppl):S51–S60PubMed
8.
Irshad M et al (2013) Cytokine and matrix metalloproteinase expression in fibroblasts from peri-implantitis lesions in response to viable Porphyromonas gingivalis. J Periodontal Res 48(5):647–656CrossRefPubMed
9.
Javed F et al (2011) Proinflammatory cytokines in the crevicular fluid of patients with peri-implantitis. Cytokine 53(1):8–12CrossRefPubMed
10.
Severino VO, Napimoga MH, de Lima Pereira SA (2011) Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis. Arch Oral Biol 56(8):823–828CrossRefPubMed
11.
Heitz-Mayfield LJ (2008) Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol 35(8 Suppl):292–304CrossRefPubMed
12.
Renvert S, Persson GR (2009) Periodontitis as a potential risk factor for peri-implantitis. J Clin Periodontol 36(Suppl 10):9–14CrossRefPubMed
13.
Strietzel FP et al (2007) Smoking interferes with the prognosis of dental implant treatment: a systematic review and meta-analysis. J Clin Periodontol 34(6):523–544CrossRefPubMed
14.
Kozlovsky A et al (2007) Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa. Clin Oral Implants Res 18(5):601–610CrossRefPubMed
15.
Nogueira-Filho G, Iacopino AM, Tenenbaum HC (2011) Prognosis in implant dentistry: a system for classifying the degree of peri-implant mucosal inflammation. J Can Dent Assoc 77:3
16.
Lang NP et al (2004) Consensus statements and recommended clinical procedures regarding implant survival and complications. Int J Oral Maxillofac Implants 19(Suppl):150–154PubMed
17.
Zeza B, Pilloni A (2012) Peri-implant mucositis treatments in humans: a systematic review. Ann Stomatol (Roma) 3(3–4):83–89
18.
Renvert S, Roos-Jansaker AM, Claffey N (2008) Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Periodontol 35(8 Suppl):305–315CrossRefPubMed
19.
Renvert S et al (2009) Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results. J Clin Periodontol 36(7):604–609CrossRefPubMed
20.
Renvert S et al (2008) Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. J Periodontol 79(5):836–844CrossRefPubMed
21.
Schar D et al (2013) Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res 24(1):104–110CrossRefPubMed
22.
Thierbach R, Eger T (2013) Clinical outcome of a nonsurgical and surgical treatment protocol in different types of peri-implantitis: a case series. Quintessence Int 44(2):137–148PubMed
23.
Esposito M, Grusovin MG, Worthington HV (2012) Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review. Eur J Oral Implantol 5(Suppl):S21–S41PubMed
24.
Esposito M et al (2008) The efficacy of interventions to treat peri-implantitis: a Cochrane systematic review of randomised controlled clinical trials. Eur J Oral Implantol 1(2):111–125
25.
Deppe H et al (2013) Nonsurgical antimicrobial photodynamic therapy in moderate vs severe peri-implant defects: a clinical pilot study. Quintessence Int 44(8):609–618PubMed
26.
van Winkelhoff AJ (2012) Antibiotics in the treatment of peri-implantitis. Eur J Oral Implantol 5(Suppl):S43–S50PubMed
27.
Schwarz F et al (2005) Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study. Clin Oral Implants Res 16(1):44–52CrossRefPubMed
28.
Kotsakis, G. A., et al. (2014) A systematic review and meta-analysis of the effect of various laser wavelengths in the treatment of peri-implantitis. J Periodontol
29.
Salvi GE et al (2007) Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes. Clin Oral Implants Res 18(3):281–285CrossRefPubMed
30.
Renvert S, Roos-Jansåker AM, Claffey N (2008) Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Periodontol 35(s8):305–315CrossRefPubMed
31.
Petković A et al (2010) Proinflammatory cytokines (IL-1β and TNF-α) and chemokines (IL-8 and MIP-1α) as markers of peri-implant tissue condition. Int J Oral Maxillofac Surg 39(5):478–485CrossRefPubMed
32.
Heitz-Mayfield LJ (2008) Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol 35(s8):292–304CrossRefPubMed
33.
Esposito M et al (2009) Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review. Eur J Oral Implantol 2(4):247–266PubMed
34.
Koop R, Merheb J, Quirynen M (2012) Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review. J Periodontol 83(6):707–720CrossRefPubMed
35.
Li W, Xiao L, Hu J (2012) The use of enamel matrix derivative alone versus in combination with bone grafts to treat patients with periodontal intrabony defects: a meta-analysis. J Am Dent Assoc 143(9):e46–e56CrossRefPubMed
36.
Hammarström L, Heijl L, Gestrelius S (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 24(9 Pt 2):669–677CrossRefPubMed
37.
Koop R, Merheb J, Quirynen M (2012) Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review. J Periodontol 83(6):707–720CrossRefPubMed
38.
Sculean A et al (2003) Histologic evaluation of human intrabony defects following non-surgical periodontal therapy with and without application of an enamel matrix protein derivative. J Periodontol 74(2):153–160CrossRefPubMed
39.
Chano L et al (2003) Emdogain® regulation of cellular differentiation in wounded rat periodontium. J Periodontal Res 38(2):164–174CrossRefPubMed
40.
Spahr A et al (2002) Effect of the enamel matrix derivative Emdogain on the growth of periodontal pathogens in vitro. J Clin Periodontol 29(1):62–72CrossRefPubMed
41.
Walter C et al (2006) Moderate effect of enamel matrix derivative (Emdogain gel) on Porphyromonas gingivalis growth in vitro. Arch Oral Biol 51(3):171–176CrossRefPubMed
42.
Wada Y, Mizuno M, Tamura M (2009) Enamel matrix derivative neutralized the effect of lipopolysaccharide on osteoprotegerin and receptor activator of nuclear factor kappa B ligand expression of osteoblasts. Arch Oral Biol 54(4):306–312CrossRefPubMed
43.
Bosshardt DD (2008) Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontol 35(s8):87–105CrossRefPubMed
44.
Jiang J et al (2001) Effects of enamel matrix derivative on gene expression of primary osteoblasts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 91(1):95–100CrossRefPubMed
45.
Qu Z et al (2010) Effect of Emdogain on proliferation and migration of different periodontal tissue-associated cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109(6):924–931CrossRefPubMed
46.
Weishaupt P et al (2008) Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(2):304–308CrossRefPubMed
47.
Kemoun P et al (2011) The role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitro. Biomaterials 32(30):7375–7388CrossRefPubMedPubMedCentral
48.
49.
Wennstrom JL, Lindhe J (2002) Some effects of enamel matrix proteins on wound healing in the dento-gingival region. J Clin Periodontol 29(1):9–14CrossRefPubMed
50.
Khedmat S et al (2010) Effects of enamel matrix derivative on the viability, cytokine secretion, and phagocytic activity of human monocytes. J Endod 36(6):1000–1003CrossRefPubMed
51.
Sculean A et al (2004) Treatment of peri-implantitis with EDTA decontamination and application of an enamel matrix protein derivate—a report of 3 cases. PERIO (Periodontal Practice Today) 1:237–245
52.
Froum SJ, Froum SH, Rosen PS (2012) Successful management of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3-to 7.5-year follow-up. International Journal of Periodontics and Restorative Dentistry 32(1):11PubMed
53.
Sanz M, Chapple IL (2012) Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol 39(Suppl 12):202–206CrossRefPubMed
54.
Etter TH et al (2002) Healing after standardized clinical probing of the perlimplant soft tissue seal. Clin Oral Implants Res 13(6):571–580CrossRefPubMed
55.
Sahm N et al (2011) Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study. J Clin Periodontol 38(9):872–878CrossRefPubMed
56.
Mellado-Valero A et al (2013) Decontamination of dental implant surface in peri-implantitis treatment: a literature review. Med Oral Patol Oral Cir Bucal 18(6):e869–e876CrossRefPubMedPubMedCentral
57.
1996) Meffert, R., Periodontitis vs. peri-implantitis: the same disease? The same treatment? Critical Reviews in Oral Biology & Medicine 7(3):278–291
58.
Froum SJ et al (2001) A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12-month re-entry study. J Periodontol 72(1):25–34CrossRefPubMed
59.
Gutierrez MA, Mellonig JT, Cochran DL (2003) Evaluation of enamel matrix derivative as an adjunct to non-surgical periodontal therapy. J Clin Periodontol 30(8):739–745CrossRefPubMed
60.
Mombelli A et al (2005) Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: clinical effects. J Clin Periodontol 32(3):225–230CrossRefPubMed
61.
Brito C et al (2014) Is keratinized mucosa indispensable to maintain peri-implant health? A systematic review of the literature. J Biomed Mater Res B Appl Biomater 102(3):643–650CrossRefPubMed
62.
Casado PL et al (2013) Peri-implant disease and chronic periodontitis: is interleukin-6 gene promoter polymorphism the common risk factor in a Brazilian population? Int J Oral Maxillofac Implants 28(1):35–43CrossRefPubMed
63.
Kadkhodazadeh M et al (2013) IL-17 gene polymorphism is associated with chronic periodontitis and peri-implantitis in Iranian patients: a cross-sectional study. Immunol Investig 42(2):156–163CrossRef
64.
65.
Froum SJ, Rosen PS (2012) A proposed classification for peri-implantitis. International Journal of Periodontics and Restorative Dentistry 32(5):533PubMed
66.
Lindhe J, Meyle J (2008) Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35(s8):282–285CrossRefPubMed
67.
Rosen P et al (2013) Peri-implant mucositis and peri-implantitis: a current understanding of their diagnoses and clinical implications. J Periodontol 84(4):436–443CrossRef
68.
Lang NP, Berglundh T (2011) Periimplant diseases: where are we now?—Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol 38(s11):178–181CrossRefPubMed
Metadaten
Titel
Effects of enamel matrix derivative on non-surgical management of peri-implant mucositis: a double-blind randomized clinical trial
verfasst von
Atabak Kashefimehr
Reza Pourabbas
Masumeh Faramarzi
Ali Zarandi
Abouzar Moradi
Howard C. Tenenbaum
Amir Azarpazhooh
Publikationsdatum
30.12.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 7/2017
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-016-2033-7

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