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Erschienen in: International Urogynecology Journal 12/2014

01.12.2014 | Original Article

Effects of phosphodiesterase type 5 inhibitor, tadalafil, on continence reflex in rats

verfasst von: Hideaki Izumi, Yasuhiro Kaiho, Minoru Miyazato, Naoki Kawamorita, Haruo Nakagawa, Yoichi Arai

Erschienen in: International Urogynecology Journal | Ausgabe 12/2014

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Abstract

Introduction and hypothesis

Effects of tadalafil, a phosphodiesterase type 5 inhibitor, on the urethral continence reflex induced by sneezing were investigated.

Methods

The amplitude of urethral pressure responses during sneezing (A-URS) and urethral baseline pressure (UBP) were measured in female rats using a microtransducer-tipped catheter. Sneeze leak-point pressure (S-LPP), defined as the lowest amount of pressure required to induce fluid leakage from the urethral orifice during sneezing, was measured in rats with stress urinary incontinence (SUI) induced by vaginal distension. Values were determined before and after tadalafil administration.

Results

Tadalafil dose dependently and significantly decreased A-URS and S-LPP. At the highest dose tested (6.0 mg/kg), A-URS and S-LPP decreased from 49.7 to 32.3 and from 63.9 to 44.2 cmH2O, respectively, whereas UBP did not significantly change.

Conclusions

Tadalafil attenuated the sneeze-induced urethral continence reflex by relaxing the striated muscles of the external urethral sphincter.
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Metadaten
Titel
Effects of phosphodiesterase type 5 inhibitor, tadalafil, on continence reflex in rats
verfasst von
Hideaki Izumi
Yasuhiro Kaiho
Minoru Miyazato
Naoki Kawamorita
Haruo Nakagawa
Yoichi Arai
Publikationsdatum
01.12.2014
Verlag
Springer London
Erschienen in
International Urogynecology Journal / Ausgabe 12/2014
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-014-2453-3

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