BACKGROUND
Methods and analysis
Study design
Patient and public involvement
Eligibility criteria
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Yoga, tai chi chuan, qigong or pilates was defined as physical intervention.
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The physical exercise intervention group performed other supportive care (e.g. dietary plan).
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Primary outcomes: resting LVEF
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Secondary outcomes: resting parameters of diastolic function [E/A’ ratio; deceleration time of early left ventricular filling (DT); isovolumetric relaxation time (IVRT); E/E’ lateral and E/E’ septal]; resting parameters of myocardial deformation imaging (strain and strain rate); cardiac biomarkers (troponin I or T; high-sensitivity troponin I or T; brain natriuretic peptide; amino terminal of B-type natriuretic peptide)
Search methodology for identification of studies
Concept | Related terms |
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#1 condition | ((breast neoplasms[MeSH]) OR ((breast[MeSH] OR breast diseases[MeSH]) AND neoplasms[MeSH])) OR ((Breast[tiab] OR mammary[tiab]) AND cancer*[tiab] OR carcinoma*[tiab] OR tumour*[tiab] OR malignant*[tiab] OR neoplasm*[tiab])) |
#2 cancer treatment | ((chemotherapy[MeSH]) OR anthracycline[MeSH]) OR trastuzumab[MeSH]) OR Antibodies, Monoclonal, Humanized[MeSH]) OR (chemotherap*[tiab] OR anthracycline*[tiab] OR trastuzumab[tiab] OR herceptin[tiab])) |
#3 exercise | ((Exercise training[MeSH]) OR Resistance training[MeSH]) OR Exercise therapy[MeSH]) OR ((Exercise[tiab] OR training[tiab] OR sport*[tiab]) AND aerobic*[tiab] OR resistance*[tiab] OR strength*[tiab] OR weight [tiab] OR endurance*[tiab])) |
#4 study type | ((randomized controlled trial[pt]) OR controlled clinical trial[pt]) OR (randomized[tiab] OR randomly[tiab] OR trial[tiab])) |
Data management
Data extraction
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Study characteristics: primary aim, authors, year of publication, journal name, country and sample size
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Participant characteristics: mean age, disease stage and treatment scheme
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Intervention characteristics: exercise type, intensity, frequency, time, supervision, location and, if provided, we will also highlight safety and feasibility
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Comparison details: placebo or control group
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Interested study outcomes: data of the study outcomes (effect size, 95% CI, standard mean deviation) and its measuring methods
Assessment risk of bias of the included studies
Heterogeneity assessment
Data synthesis
Assessment of reporting bias
Subgroups analyses
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Intervention type (aerobic or resistance, concomitant or isolated)
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Exercise intensity (light, moderate, vigorous)
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Treatment scheme (including anthracyclines or trastuzumab, concomitant or isolated)