Erschienen in:
01.05.2005 | Original Article
Efficacy of etidronate and sequential monofluorophosphate in severe postmenopausal osteoporosis: a pilot study
verfasst von:
J. D. Ringe, A. Dorst, H. Faber, C. Kipshoven, L. C. Rovati, I. Setnikar
Erschienen in:
Rheumatology International
|
Ausgabe 4/2005
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Abstract
In a three-year pilot study on 52 women with severe postmenopausal osteoporosis, treatment with etidronate followed by calcium and vitamin D (ECaD) was compared to etidronate followed by monofluorophosphate, calcium and vitamin D (EFCaD). BMD in lumbar spine, total hip and femoral neck increased significantly more with EFCaD than with ECaD. Pain-mobility score decreased significantly more with EFCaD than with ECaD (p=0.006). New vertebral fractures occurred in three patients under EFCaD (12%) and in nine under ECaD (35%), (p=0.048). Three patients under EFCaD (12%) and 15 under ECaD (58%) did not respond to therapy (p of difference=0.001). Mild or moderate adverse reactions were reported by 25 patients, with no significant difference between the two groups. The pilot study suggests that etidronate, sequentially followed by monofluorophosphate, could be a safe, effective and relatively inexpensive therapy in severe postmenopausal osteoporosis.