Background
Methods
Evidence base
Outcomes of interest
Analysis
Results
Study and patient characteristics
Source | Trial Design1
| Arm 1 | Centres/Countries2
| Inclusion criteria3
| Background treatment allowed4
| Background treatment not allowed4
|
---|---|---|---|---|---|---|
MOITA, 2008 | 12 week RCT, PC, DB, MC | Tiotropium; 18 μg; OD (n = 147) vs. Placebo (n = 164) | 31 centres/ Portugal | FEV1 ≤ 70 %; FEV1/FVC ≤ 70 %; excluded if ≥ 3 exacerbations previous year | LABAs, theophylline, mucolytics, ICS, stable doses oral corticosteroids. Temporary increases in theophylline or oral steroids for exacerbations | Theophylline 24 h preparations |
VERKINDRE, 2006 | 12 week RCT, PC, DB, MC | Tiotropium; 18 μg; OD (n = 46) vs. Placebo (n = 54) | 10 centres/ France | FEV1 ≤ 50 %; FEV1/SVC ≤ 70 %; residual volume ≥ 125 %; excluded if unstable doses oral corticosteroid 6 wks prior | Stable doses oral corticosteroids, ICS, theophylline preparations, mucolytic agents | Use of SABAs, oral ß2-agonists, or LABAs |
COVELLI, 2005 | 12 week RCT, PC, DB, MC | Tiotropium; 18 μg; OD (n = 100) vs. Placebo (n = 96) | 12 centres/ USA | FEV1 ≤ 60 %; FEV1/FVC ≤ 70 %; excluded if exacerbation in prior 6 wks | ICS, LABAs and theophyllines | Cromones, leukotriene antagonists, and inhaled anticholinergics |
CASABURI, 2000 | 13 week RCT, PC, DB, MC | Tiotropium; 18 μg; O (n = 279) vs. Placebo (n = 191) | 25 centres/ USA | FEV1 ≤ 65 %; FEV1/FVC ≤ 70 % | Stable doses of theophylline, ICS, oral prednisone | Other inhaled or oral bronchodilators |
CASABURI, 2002 | Two 56 week RCTs, PC, DB, MC | Tiotropium; 18 μg; OD (n = 550) vs. Placebo (n = 371) | 50 centers/ countries NR | FEV1 ≤ 65 %; FEV1/FVC ≤ 70 %; | Stable doses of theophylline, ICS, oral prednisone | NR |
NIEWOEHNER, 2005 | 24 week RCT, PC, DB, MC | Tiotropium; 18 μg; OD (n = 914) vs. Placebo (n = 915) | 26 centers/ USA | FEV1 ≤ 60 %; FEV1/FVC ≤ 70 %; excluded if not recovered from exacerbation ≥ 30 days prior | All other respiratory medications (including ICS and LABAs) | Open-label anticholinergic bronchodilator |
CHAN, 2007 | 48 week RCT, PC, DB, MC | Tiotropium; 18 μg, OD (n = 608) vs. Placebo (n = 305) | 101 centers/ Canada | FEV1 ≤ 65 %; FEV1/FVC ≤ 70 %; included if ≥ 1 exacerbation previous year but not in 6 weeks prior | Stable dose oral corticosteroids, ICS, theophylline preparations, mucolytic preparations (not containing bronchodilators), LABAs | NR |
TONNEL, 2008 | 36 week RCT, PC, DB, MC | Tiotropium; 18 μg: OD (n = 266) vs. Placebo (n = 288) | 123 centers/ France | FEV1 20-70 %; FEV1/FVC ≤ 70 %; | Stable doses of theophylline preparations (excluding 24-hour preparations), mucolytics, ICS, and oral steroids | NR |
HANANIA, 2003 | 24 week RCT, PC, DB, MC | Salmeterol; 50 μg; BID (n = 177) vs. Placebo (n = 185) | 76 centres/ USA | FEV1 >40 % and <65 %; FEV1/FVC < 70 %; symptoms criteria; excluded if oral corticosteroids 6 wks prior | Stable regimen of theophylline | All other corticosteroids and bronchodilators |
MAHLER, 2002 | 24 week RCT, PC, DB, MC, DD | Salmeterol; 50 μg; BID (n = 160) vs. Placebo (n = 181) | 65 centers/ countries NR | FEV1 <65 % but >70 L. FEV1/FVC ≤70 %; excluded if moderate or severe exacerbation during run-in | Theophylline | Corticosteroids and other bronchodilators |
VAN RUTTEN, 1999 | 12 week RCT, PC, DB, MC, DD | Salmeterol; 50 μg; BID (n = 47) vs. Placebo (n = 50) | 3 centers/ Netherlands | FEV1 ≥40 % and ≤65 %; FEV1/FVC < 60 % (post salbutamol); symptoms criteria; | Stable doses of maintenance drugs | NR |
CELLI, 2003 | 12 week RCT, PC, DB, MC, DD | Salmeterol; 50 μg; BID (n = 554) vs. Placebo (n = 271) | 189 centres/ 15 countries | FEV1 20-70 %; FEV1/FVC < 65 %; <15 % reversibility FEV1; symptom criteria; excluded if exacerbation 6 wks prior | Usual medications at stable dose | β2-adrenoceptor agonists, anticholinergics, antibiotics for respiratory tract infection, leukotriene antagonists |
GROSS, 2008 | 12 week RCT, PC, DB, DD, MC | Formoterol; 12 μg; BID (n = 114) vs. Placebo (n = 114) | 38 centres/ USA | FEV1 >30 %; FEV1/FVC < 70 %; symptom criteria; excluded if exacerbation in 4 wks prior | Stable doses of inhaled or oral corticosteroids | NR |
ROSSI, 2002 | 12 month RCT, PC,DB,MC | Formoterol; 12 μg; BID (n = 211) vs. Placebo (n = 220) | 81 centers worldwide | FEV1 < 70 % of the predicted value and ≥ 0.75 L, FEV1 vital capacity ratio of <88 % of that predicted in men and <89 % in women. | Inhaled salbutamol (100 microgram per puff) or equivalent doses of albuterol in US centers as needed | NR |
DAHL, 2001 | 12 week RCT, PC, DB, DD, MC | Formoterol 12 μg; BID (n = 194) vs. Placebo (n = 200) | 57 centres/ Europe, Russia, Canada, USA | FEV1 <70 %; FEV1/FVC < 88 % for men and <89 % for women; symptom criteria; excluded if used oral corticosteroids 4 wks prior | Stable ICS, short courses of antibiotics, oral corticosteroids, and/or oxygen in case of exacerbation or respiratory infection | NR |
BRIGGS, 2005 | 12 week RCT, DB, MC | Tiotropium 18 μg; OD (n = 328) vs. Salmeterol; 50 μg; BID (n = 325) | 50 centres/ Europe, UK and USA | FEV1 ≤ 60 %; FEV1/FVC ≤ 70 %; excluded if exacerbation 4 wks prior | All usual medications | LABAs different from study medication |
B2334, 2008/ DAHL, 2010 | 52 week RCT, PC, DB, MC, DD | Indacaterol; 300 μg; OD (n = 437) vs. Formoterol; 12 μg; BID (n = 435) vs. Placebo (n = 432) | # centres NR/ 25 countries in S. America, Europe, Russia, Africa, and Asia | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; reversible and non-reversible patients included; excluded if hospitalisation 6 wks prior to trial or during run-in period | ICS monotherapy | Tiotropium, short acting anti-cholinergics, fixed combinations of β2-agonists and ICS or β 2-agonists and inhaled anticholinergics, LABAs, and other SABAs, theophylline, other xanthines, parenteral or oral corticosteroids |
B2335S, 2008/ DONOHUE, 2010 | 26 week RCT, PC, DB (except for tiotropium arm), MC, DD; Adaptive seamless | Indacaterol; 150 μg; OD (n = 420) vs. Indacaterol; 300 μg; OD (n = 418) vs. Tiotropium; 18 μg; OD (n = 410) vs. Placebo (n = 425) | # centres NR/ Argentina, Canada, Europe, India, Italy, Korea, Taiwan, USA | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; reversible and non-reversible patients included; excluded if hospitalisation 6 wks prior | ICS monotherapy | Tiotropium, short acting anti-cholinergics, fixed combinations of β2-agonists and ICS or β 2-agonists and inhaled anticholinergics, LABAs, and other SABAs, theophylline, other xanthines, parenteral or oral corticosteroids |
B2336, 2009/ KORNMANN, 2010 | 26 week RCT, PC, DB, MC, DD | Indacaterol; 150 μg; OD (n = 333) vs. Salmeterol; 50 μg; BID (n = 334) vs. Placebo (n = 335) | # centres NR/ Canada, Colombia, Europe and Russia, Slovakia, India, Peru, Taiwan | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; reversible and non-reversible patients included; excluded if hospitalisation 6 wks prior | ICS monotherapy | Tiotropium, short acting anti-cholinergics, fixed combinations of β2-agonists + ICS or β 2- agonists + inhaled anticholinergics, LABAs, theophylline, other xanthines, parenteral or oral corticosteroids |
B2346, 2008/ FELDMAN, 2010 | 12 week RCT, PC, DB, MC, DD | Indacaterol; 150 μg; OD (n = 211) vs. Placebo (n = 205) | # centres NR/ USA, Australia/ New Zealand, Belgium | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; reversible and non-reversible patients included; excluded if hospitalisation 6 wks prior | ICS monotherapy | Tiotropium, short acting anti-cholinergics, fixed combinations of β2-agonists and ICS or β 2-agonists and inhaled anticholinergics, LABAs, and other SABAs, theophylline, other xanthines, parenteral or oral corticosteroids |
B2354, 2010 | 12 week RCT, PC, DB, MC | Indacaterol; 75 μg; OD (n = 163) vs. Placebo (n = 160) | # centres NR/ USA | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; Excluded if exacerbation in 6 wks prior | Antibiotics or oral corticosteroids for exacerbation; ICS monotherapy | LABAs; anticholinergic |
B2355, 2010 | 12 week RCT, PC, DB, MC | Indacaterol; 75 μg; OD (n = 159) vs. Placebo (n = 159) | # centres NR/ USA | FEV1 ≥ 30 % and <80 %; FEV1/FVC < 70 %; Excluded if exacerbation in 6 wks prior | Antibiotics or oral corticosteroids for exacerbation; ICS monotherapy | LABAs; anticholinergic |
Author | Treatment | % Male1
| Age (sd or range)2
| % Current smoker3
| % Severe4
| % on ICS5
| FEV1 mean L (sd)6
| Reversibility post-SABA (sd)7
|
---|---|---|---|---|---|---|---|---|
MOITA, 2008 | Tiotropium; 18 μg; OD | NR | NR | 28 % | NR | NR | NR | NR |
Placebo | NR | NR | 25 % | NR | NR | NR | NR | |
VERKINDRE, 2006 | Tiotropium; 18 μg; OD | 94 % | 61 (9.5) | 24 % | 95 % | NR | 1.05 (0.4) | NR |
Placebo | 94 % | 60 (10.2) | 33 % | 94 % | NR | 1.08 (0.3) | NR | |
COVELLI, 2005 | Tiotropium; 18 μg; OD | 66 % | 66 (8.9) | 40 % | 77 % | 54 % | 1.06 (0.4) | NR |
Placebo | 49 % | 63 (9.2) | 37 % | 80 % | 58 % | 0.99 (0.4) | NR | |
CASABURI, 2000 | Tiotropium; 18 μg; OD | 67 % | 65 (8.6) | NR | 79 % | NR | 1.04 (0.4) | NR |
Placebo | 63 % | 66 (9.0) | NR | 80 % | NR | 1.00 (0.4) | NR | |
CASABURI, 2002 | Tiotropium; 18 μg; OD | 67 % | 65 (9.0) | NR | 79 % | 44 % | 1.04 (0.4) | NR |
Placebo | 63 % | 65 (9.0) | NR | 80 % | 40 % | 1.00 (0.4) | NR | |
NIEWOEHNER, 2005 | Tiotropium; 18 μg; OD | 98 % | 68 (8.7) | 29 % | 87 % | 61 % | 1.04 (0.4) | NR |
Placebo | 99 % | 68 (8.5) | 30 % | 87 % | 58 % | 1.04 (0.4) | NR | |
CHAN, 2007 | Tiotropium; 18 μg, OD | 59 % | 68 (8.7) | 32 % | 79 % | 66 % | 0.97 (0.4) | NR |
Placebo | 61 % | 67 (9.1) | 30 % | 78 % | 71 % | 0.96 (0.4) | NR | |
TONNEL, 2008 | Tiotropium; 18 μg: OD | 87 % | 65 (9.7) | 24 % | 58 % | 38 % | 1.38 (0.4) | NR |
Placebo | 85 % | 64 (10.1) | 30 % | 62 % | 36 % | 1.35 (0.5) | NR | |
HANANIA, 2003 | Salmeterol; 50 μg; BID | 58 % | 64 (42–87) | 51 % | 75 % | 0 % | 1.25 (0.4) | NR |
Placebo | 68 % | 65 (40–81) | 47 % | 75 % | 0 % | 1.29 (0.4) | NR | |
MAHLER, 2002 | Salmeterol; 50 μg; BID | 64 % | 64 (40–84) | 46 % | NR | 31 % | 1.23 (NR) | NR |
Placebo | 75 % | 64 (44–90) | 54 % | NR | 18 % | 1.31 (NR) | NR | |
VAN RUTTEN, 1999 | Salmeterol; 50 μg; BID | 89 % | 65 (5.8) | NR | 73 % | 81 % | 1.30 (0.4) | NR |
Placebo | 86 % | 63 (7.4) | NR | 77 % | 76 % | 1.30 (0.4) | NR | |
CELLI, 2003 | Salmeterol; 50 μg; BID | 80 % | 64 (8.7) | NR | 73 % | NR | 1.30 (0.5) | NR |
Placebo | 71 % | 65 (8.7) | NR | 69 % | NR | 1.35 (0.5) | NR | |
GROSS, 2008 | Formoterol; 12 μg; BID | 54 % | 63 (9.4) | 54 % | 70 % | 23 % | 1.30 (0.4) | 15 % (NR) |
Placebo | 57 % | 64 (9.2) | 54 % | 64 % | 19 % | 1.36 (0.5) | 11 % (NR) | |
ROSSI, 2002 | Formoterol; 12 μg; BID | 87 % | 63 (NR) | NR | NR | NR | 1.36 (NR) | NR |
Placebo | 80 % | 63 (NR) | NR | NR | NR | 1.40 (NR) | NR | |
DAHL, 2001 | Formoterol; 12 μg; BID | 74 % | 64 (8.8) | 46 % | 63 % | 47 % | 1.33 (0.5) | NR |
Placebo | 79 % | 63 (9.0) | 49 % | 68 % | 54 % | 1.29 (0.4) | NR | |
BRIGGS, 2005 | Tiotropium; 18 μg; OD | 65 % | 64 (8.6) | 35 % | 86 % | 54 % | 1.05 (0.4) | 14 % (NR) |
Salmeterol; 50 μg; BID | 68 % | 65 (7.8) | 37 % | 84 % | 47 % | 1.04 (0.4) | 18 % (NR) | |
B2334, 2008 DAHL, 2010 | Indacaterol; 300 μg; OD | 80 % | 64 (8.6) | 42 % | 46 % | 56 % | 1.48 (0.5) | 12 % (13 %) |
Formoterol; 12 μg; BID | 80 % | 64 (8.5) | 41 % | 44 % | 51 % | 1.50 (0.5) | 12 % (13 %) | |
Placebo | 82 % | 63 (8.3) | 40 % | 45 % | 52 % | 1.52 (0.5) | 13 % (13 %) | |
B2335S, 2008 DONOHUE, 2010 | Indacaterol; 150 μg; OD | 62 % | 63 (9.4) | 45 % | 38 % | 38 % | 1.52 (0.5) | 16 % (15 %) |
Indacaterol; 300 μg; OD | 63 % | 63 (9.3) | 45 % | 38 % | 37 % | 1.53 (0.5) | 15 % (15 %) | |
Tiotropium; 18 μg; OD | 65 % | 64 (8.8) | 45 % | 43 % | 35 % | 1.45 (0.5) | 16 % (18 %) | |
Placebo | 61 % | 64 (8.9) | 46 % | 40 % | 40 % | 1.51 (0.5) | 16 % (18 %) | |
B2336, 2009 KORNMANN, 2010 | Indacaterol; 150 μg; OD | 72 % | 63 (8.7) | 46 % | 42 % | 45 % | 1.48 (0.5) | 12 % (15 %) |
Salmeterol; 50 μg; BID | 75 % | 63 (9.2) | 46 % | 43 % | 46 % | 1.48 (0.5) | 11 % (14 %) | |
Placebo | 77 % | 64 (8.6) | 45 % | 44 % | 40 % | 1.46 (0.5) | 13 % (16 %) | |
B2346, 2008 FELDMAN, 2010 | Indacaterol; 150 μg; OD | 51 % | 63 (9.9) | 51 % | 40 % | 29 % | 1.50 (0.5) | 16 % (17 %) |
Placebo | 54 % | 63 (9.6) | 53 % | 38 % | 34 % | 1.50 (0.5) | 17 % (19 %) | |
B2354, 2010 | Indacaterol; 75 μg; OD | 55 % | 64 (8.3) | 44 % | 41 % | 43 % | NR | 15 % (13 %) |
Placebo | 54 % | 64 (9.4) | 44 % | 44 % | 48 % | NR | 17 % (14 %) | |
B2355, 2010 | Indacaterol; 75 μg; OD | 52 % | 61 (9.8) | 58 % | 30 % | 40 % | NR | 18 % (17 %) |
Placebo | 56 % | 62 (9.9) | 60 % | 45 % | 35 % | NR | 16 % (14 %) |
Network meta-analysis
PLBO | TIO 18 | SAL 50 | FOR 12 | IND 300 | IND 150 | IND 75 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | ||
B2334, 2008; | N | 371 | 347 | 379 | 359 | 389 | 372 | ||||||||
B | 1.3 | 43.6 | 1.3 | 44.3 | 1.3 | 44.5 | |||||||||
sd | 0.5 | 17.8 | 0.4 | 17.3 | 0.4 | 17.1 | |||||||||
12 wks | 1.4 | 41.6 | 1.4 | 39.1 | 1.4 | 38.5 | |||||||||
sd | 0.5 | 18.5 | 0.5 | 18.4 | 0.5 | 17.9 | |||||||||
B2335S, 2008; | N | 376 | 347 | 393 | 374 | 389 | 375 | 389 | 368 | ||||||
B | 1.3 | 45.7 | 1.2 | 44.6 | 1.2 | 44.6 | 1.3 | 45.4 | |||||||
sd | 0.5 | 17.3 | 0.5 | 18.1 | 0.5 | 18.7 | 0.5 | 19.1 | |||||||
12 wks | 1.3 | 42.7 | 1.4 | 41.0 | 1.4 | 39.5 | 1.5 | 39.9 | |||||||
sd | 0.5 | 18.3 | 0.5 | 18.4 | 0.5 | 18.9 | 0.5 | 19.6 | |||||||
B2336, 2009 | N | 316 | 294 | 316 | 300 | 320 | 309 | ||||||||
B | 1.3 | 43.6 | 1.3 | 43.2 | 1.3 | 43.6 | |||||||||
sd | 0.5 | 17.8 | 0.5 | 18.5 | 0.5 | 18.7 | |||||||||
12 wks | 1.3 | 42.4 | 1.4 | 37.7 | 1.5 | 35.9 | |||||||||
sd | 0.5 | 19.6 | 0.5 | 18.5 | 0.6 | 19.4 | |||||||||
B2346, 2008 | N | 189 | 187 | 201 | 199 | ||||||||||
B | 1.3 | 48.7 | 1.3 | 50.1 | |||||||||||
sd | 0.6 | 18.9 | 0.6 | 18.9 | |||||||||||
12 wks | 1.4 | 47.6 | 1.5 | 43.9 | |||||||||||
sd | 0.6 | 19.2 | 0.6 | 19.7 | |||||||||||
B23354, 2010 | N | 148 | 142 | 149 | 147 | ||||||||||
B | 1.3 | 49.5 | 1.3 | 48.6 | |||||||||||
sd | 0.5 | 17.3 | 0.5 | 18.7 | |||||||||||
12 wks | 1.3 | 47.6 | 1.4 | 42.8 | |||||||||||
sd | 0.5 | 17.3 | 0.5 | 18.2 | |||||||||||
B23355, 2010 | N | 150 | 145 | 145 | 148 | ||||||||||
B | 1.3 | 50.1 | 1.4 | 51.2 | |||||||||||
sd | 0.5 | 18.1 | 0.5 | 18.1 | |||||||||||
12 wks | 1.3 | 49.2 | 1.5 | 46.2 | |||||||||||
sd | 0.5 | 20.1 | 0.6 | 20.0 |
PLBO | TIO 18 | SAL 50 | FOR 12 | IND 300 | IND 150 | IND 75 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | FEV1
| SGRQ | ||
MOITA, 2008 | diff | 0 | 0 | 0.10 | |||||||||||
se | 0.03 | ||||||||||||||
VERKINDRE, 2006 | diff | 0 | 0 | 0.11 | −6.50 | ||||||||||
se | 0.04 | 2.90 | |||||||||||||
COVELLI, 2005 | diff | 0 | 0 | 0.18 | |||||||||||
se | 0.04 | ||||||||||||||
CASABURI, 2000 | diff | 0 | 0 | 0.15 | |||||||||||
se | 0.01 | ||||||||||||||
CASABURI, 2002 | diff | 0 | 0 | 0.13 | |||||||||||
se | 0.02 | ||||||||||||||
NIEWOEHNER, 2005 | diff | 0 | 0 | 0.10 | |||||||||||
se | 0.01 | ||||||||||||||
CHAN, 2007 | diff | 0 | 0 | 0.10 | |||||||||||
se | 0.02 | ||||||||||||||
TONNEL, 2008 | diff | 0 | 0 | −3.47 | |||||||||||
se | 1.10 | ||||||||||||||
HANANIA, 2003 | diff | 0 | 0 | 0.10 | |||||||||||
se | 0.03 | ||||||||||||||
MAHLER, 2002 | diff | 0 | 0 | 0.13 | |||||||||||
se | 0.02 | ||||||||||||||
VAN RUTTEN, 1999 | diff | 0 | 0 | −0.51 | |||||||||||
se | 1.66 | ||||||||||||||
CELLI, 2003 | diff | 0 | 0 | −2.10 | |||||||||||
se | 1.28 | ||||||||||||||
GROSS, 2008 | diff | 0 | 0 | 0.08 | −3.51 | ||||||||||
se | 0.03 | 1.73 | |||||||||||||
ROSSI, 2002 | diff | 0 | 0 | 0.04 | |||||||||||
se | 0.02 | ||||||||||||||
DAHL, 2001 | diff | 0 | 0 | −5.10 | |||||||||||
se | 1.73 | ||||||||||||||
B2334, 2008; | diff | 0 | 0 | 0.07 | −3.20 | 0.17 | −3.80 | ||||||||
se | 0.02 | 0.90 | 0.02 | 0.90 | |||||||||||
B2335S, 2008; | diff | 0 | 0 | 0.14 | −1.10 | 0.18 | −2.50 | 0.18 | −2.80 | ||||||
se | 0.02 | 0.86 | 0.02 | 0.86 | 0.02 | 0.87 | |||||||||
B2336, 2009 | diff | 0 | 0 | 0.11 | −4.20 | 0.17 | −6.30 | ||||||||
se | 0.02 | 1.01 | 0.02 | 0.99 | |||||||||||
B2346, 2008 | diff | 0 | 0 | 0.13 | −4.75 | ||||||||||
se | 0.02 | 1.22 | |||||||||||||
B23354, 2010 | diff | 0 | 0 | 0.12 | −3.80 | ||||||||||
se | 0.02 | 1.21 | |||||||||||||
B23355, 2010 | diff | 0 | 0 | 0.14 | −3.60 | ||||||||||
se | 0.02 | 1.40 | |||||||||||||
BRIGGS, 2005 | diff | 0.02 | 0 | ||||||||||||
se | 0.02 |
Trough FEV1L Difference (95%CrI) | SGRQ total score Difference1(95%CrI) | |||
---|---|---|---|---|
IPD | AD | IPD | AD | |
Tiotropium 18 | 0.13 (0.10; 0.17) | 0.13 (0.12; 0.15) | −1.60 (−3.18;-0.05) | −2.99 (−6.48; 0.43) |
Salmeterol 50 | 0.11 (0.07; 0.15) | 0.11 (0.09; 0.13) | −3.32 (−5.27;-1.37) | −2.52 (−5.34; 0.44) |
Formoterol 12 | 0.06 (0.03; 0.10) | 0.06 (0.04; 0.09) | −2.63 (−4.25;-0.94) | −3.87 (−6.95; -1.16) |
Indacaterol 75 | 0.13 (0.10; 0.16) | 0.11 (0.08; 0.14) | −3.02 (−4.87;-1.22) | −4.26 (−7.83; -0.41) |
Trough FEV1L | SGRQ total score | |||||||
---|---|---|---|---|---|---|---|---|
IPD | AD | IPD | AD | |||||
Difference (95%CrI) | Prob. better | Difference (95%CrI) | Prob. better | Difference (95%CrI) | Prob. better | Difference (95%CrI) | Prob. better | |
Tiotropium 18 | 0.00 (−0.05; 0.04) | 44 % | −0.02 (−0.06; 0.01) | 12 % | −1.42 (−3.84; 0.97) | 88 % | −1.27 (−5.95; 3.74) | 72 % |
Salmeterol 50 | 0.02 (−0.03; 0.07) | 79 % | 0.00 (−0.04; 0.04) | 53 % | 0.28 (−2.35; 2.97) | 42 % | −1.74 (−6.89; 3.54) | 77 % |
Formoterol 12 | 0.07 (0.02; 0.11) | >99 % | 0.05 (0.01; 0.09) | 99 % | −0.40 (−2.90; 2.07) | 62 % | −0.38 (−4.99; 4.87) | 57 % |