Introduction
Isolation and characterization of chemical constituents
Chemistry of garcinol
Biological activities of garcinol
a. Antioxidant Activity
b. Anti-inflammatory activity
c. Anticancer activity
d. Anti-HIV Activity
e. Anti-ulcer activity
Structure-activity considerations for garcinol
Chalcones as a garcinol analoges
a. Structural chemistry of chalcones
b. Biological Activities of chalcones
Why Chalcones are good analogs of Garcinol?
1. Structural Similarity
2. Reaction Similarity
3. Similarity in Biological Activities
4. Metal Complexation
Conclusions and perspectives
Activity | Observations | Reference |
---|---|---|
Anti-oxidant
| Efficient scavenging of free radicals | Yamaguchi et al. [17] |
Yamaguchi et al.[28] | ||
Inhibition of NO and H2O2 production | Sang et al. [18] | |
Inhibition of NO and iNOS Generation | Sang et al. [19] | |
Inhibition of iNOS and COX-2 expression | Liao et al. [31] | |
Inhibition of NO accumulation | Liao et al. [30] | |
Anti-bacterial
| Activity against methicillin-resistant Staphylococcus aureus | Iinuma et al. [23] |
Rukachaisirikul et al. [22] | ||
Efficient killing of Helicobacter pylori | Chatterjee et al. [20] | |
Chatterjee et al. [21] | ||
Anti-cancer
| Chemoprevention of colon tumorigenesis | Tanaka et al. [34] |
Induction of caspase-3-mediated apoptosis | Pan et al. [5] | |
Loss of mitochondrial potential and activation of caspase-3 | Matsumoto et al. [36] | |
Induction of apoptosis | Balasubramanyam et al. [40] | |
Inhibition of tongue carcinogenesis | Yoshida et al. [38] | |
Modulation of arachidonic acid metabolism and inhibition of STAT-1 | Hong et al. [29] | |
Selective killing of colon cancer cells | Hong et al. [33] | |
Induction of apoptosis and inhibition of cell invasion | Liao et al. [35] |