nach oben

Current Atherosclerosis Reports

Erschienen in:

01.07.2016 | Clinical Trials and Their Interpretations (J. Kizer, Section Editor)

Endovascular Interventions in Acute Ischemic Stroke: Recent Evidence, Current Challenges, and Future Prospects

verfasst von: Ramana Appireddy, Charlotte Zerna, Bijoy K Menon, Mayank Goyal

Erschienen in: Current Atherosclerosis Reports | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Abstract

After many years of clinical research, endovascular thrombectomy has been conclusively proven to be an effective treatment in acute ischemic stroke. The evidence is compelling; however, it is generated in high volume stroke centers with stroke expertise. Challenges remain ahead on translating and implementing this evidence in routine clinical care across the world. The current evidence has opened up avenues for further research and innovation in this field. In this review, we will discuss the evolution of evidence on endovascular thrombectomy followed by a discussion of challenges and future prospects in this exciting field of stroke care.

Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372(1):11–20.CrossRefPubMed

Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372(11):1009–18.CrossRefPubMed

Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372(11):1019–30.CrossRefPubMed

Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 h after symptom onset in ischemic stroke. N Engl J Med. 2015;372(24):2296–306.CrossRefPubMed

Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372(24):2285–95.CrossRefPubMed

6.••

Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016. Recent individual patient level metaanalysis of the 5 RCT’s published by the HERMES collaboration.

Lewandowski CA, Frankel M, Tomsick TA, et al. Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) bridging trial. Stroke; J Cereb Circ. 1999;30(12):2598–605.CrossRef

Investigators IMSS. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke; J Cereb Circ. 2004;35(4):904–11.CrossRef

Investigators IIT. The Interventional Management of Stroke (IMS) II Study. Stroke; J Cereb Circ. 2007;38(7):2127–35.CrossRef

10.

Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke; J Cereb Circ. 2005;36(7):1432–8.CrossRef

11.

Smith WS, Sung G, Saver J, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke; J Cereb Circ. 2008;39(4):1205–12.CrossRef

12.

Penumbra Pivotal Stroke Trial I. The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke; J Cereb Circ. 2009;40(8):2761–8.CrossRef

13.

Kidwell CS, Jahan R, Gornbein J, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013;368(10):914–23.CrossRefPubMedPubMedCentral

14.

Ciccone A, Valvassori L, Nichelatti M, et al. Endovascular treatment for acute ischemic stroke. N Engl J Med. 2013;368(10):904–13.CrossRefPubMedPubMedCentral

15.

Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med. 2013;368(10):893–903.CrossRefPubMedPubMedCentral

16.

Khatri P, Yeatts SD, Mazighi M, et al. Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial. Lancet Neurol. 2014;13(6):567–74.CrossRefPubMedPubMedCentral

17.

Menon BK, Almekhlafi MA, Pereira VM, et al. Optimal workflow and process-based performance measures for endovascular therapy in acute ischemic stroke: analysis of the Solitaire FR thrombectomy for acute revascularization study. Stroke; J Cereb Circ. 2014;45(7):2024–9.CrossRef

18.

Nambiar V, Sohn SI, Almekhlafi MA, et al. CTA collateral status and response to recanalization in patients with acute ischemic stroke. AJNR Am J Neuroradiol. 2014;35(5):884–90.CrossRefPubMed

19.

Almekhlafi MA, Hockley A, Desai JA, et al. Overcoming the evening/weekend effects on time delays and outcomes of endovascular stroke therapy: the Calgary Stroke Program experience. J Neurointerventional Surg. 2014;6(10):729–32.CrossRef

20.

Hill MD, Demchuk AM, Goyal M, et al. Alberta Stroke Program early computed tomography score to select patients for endovascular treatment: Interventional Management of Stroke (IMS)-III Trial. Stroke; J Cereb Circ. 2014;45(2):444–9.CrossRef

21.

Gupta R, Vora NA, Horowitz MB, et al. Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization. Stroke; J Cereb Circ. 2006;37(4):986–90.CrossRef

22.

Levy EI, Ecker RD, Horowitz MB, et al. Stent-assisted intracranial recanalization for acute stroke: early results. Neurosurgery. 2006;58(3):458–63.

23.

Saver JL, Jahan R, Levy EI, et al. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet. 2012;380(9849):1241–9.CrossRefPubMed

24.

Nogueira RG, Lutsep HL, Gupta R, et al. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet. 2012;380(9849):1231–40.CrossRefPubMedPubMedCentral

25.

Brandler ES, Sharma M, Sinert RH, Levine SR. Prehospital stroke scales in urban environments: a systematic review. Neurology. 2014;82(24):2241–9.CrossRefPubMedPubMedCentral

26.

Nakae T, Kataoka H, Kuwata S, Iihara K. Smartphone-assisted prehospital medical information system for analyzing data on prehospital stroke care. Stroke; J Cereb Circ. 2014;45(5):1501–4.CrossRef

27.

Yperzeele L, Van Hooff RJ, De Smedt A, et al. Prehospital stroke care: limitations of current interventions and focus on new developments. Cerebrovasc Dis. 2014;38(1):1–9.CrossRefPubMed

28.

Barber PA, Demchuk AM, Zhang J, Buchan AM. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet. 2000;355(9216):1670–4.CrossRefPubMed

29.

Alberta Stroke Program Early CT score (ASPECTS) [cited 2016 Mar 07]. Available from: https://aspectsinstroke.com/aspectsinstroke.com.

30.

Yoo AJ, Zaidat OO, Chaudhry ZA, et al. Impact of pretreatment noncontrast CT Alberta Stroke Program Early CT Score on clinical outcome after intra-arterial stroke therapy. Stroke; J Cereb Circ. 2014;45(3):746–51.CrossRef

31.

Hill MD, Demchuk AM, Tomsick TA, Palesch YY, Broderick JP. Using the baseline CT scan to select acute stroke patients for IV-IA therapy. AJNR Am J Neuroradiol. 2006;27(8):1612–6.PubMed

32.

Hill MD, Rowley HA, Adler F, et al. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke; J Cereb Circ. 2003;34(8):1925–31.CrossRef

33.

Menon BK, Puetz V, Kochar P, Demchuk AM. ASPECTS and other neuroimaging scores in the triage and prediction of outcome in acute stroke patients. Neuroimaging Clin N Am. 2011;21(2):407–23. xii.CrossRefPubMed

34.

Demchuk AM, Goyal M, Yeatts SD, et al. Recanalization and clinical outcome of occlusion sites at baseline CT angiography in the Interventional Management of Stroke III trial. Radiology. 2014;273(1):202–10.CrossRefPubMedPubMedCentral

35.

Mishra SM, Dykeman J, Sajobi TT, et al. Early reperfusion rates with IV tPA are determined by CTA clot characteristics. AJNR Am J Neuroradiol. 2014;35(12):2265–72.CrossRefPubMed

36.

Liebeskind DS. Collaterals in acute stroke: beyond the clot. Neuroimaging Clin N Am. 2005;15(3):553–73. x.CrossRefPubMed

37.

Liebeskind DS, Tomsick TA, Foster LD, et al. Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial. Stroke; J Cereb Circ. 2014;45(3):759–64.CrossRef

38.

Campbell BC, Christensen S, Levi CR, et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke; J Cereb Circ. 2011;42(12):3435–40.CrossRef

39.•

d’Esterre CD, Boesen ME, Ahn SH, et al. Time-dependent computed tomographic perfusion thresholds for patients with acute ischemic stroke. Stroke; J Cereb Circ. 2015;46(12):3390–7. The work highlights new understanding of the CT perfusion thresholds in acute ischemic stroke.CrossRef

40.

Goyal M, Almekhlafi MA, Fan L, et al. Evaluation of interval times from onset to reperfusion in patients undergoing endovascular therapy in the Interventional Management of Stroke III trial. Circulation. 2014;130(3):265–72.CrossRefPubMedPubMedCentral

41.

Mocco J, Fargen KM, Goyal M, et al. Neurothrombectomy trial results: stroke systems, not just devices, make the difference. Int J Stroke: Off J Int Stroke Soc. 2015;10(7):990–3.CrossRef

42.

Adams Jr HP, Biller J. Future of subspecialty training in vascular neurology. Stroke; J Cereb Circ. 2014;45(12):3730–3.CrossRef

43.

Leira EC, Kaskie B, Froehler MT, Adams Jr HP. The growing shortage of vascular neurologists in the era of health reform: planning is brain! Stroke; J Cereb Circ. 2013;44(3):822–7.CrossRef

44.

Zaidat OO, Lazzaro M, McGinley E, et al. Demand–supply of neurointerventionalists for endovascular ischemic stroke therapy. Neurology. 2012;79(13 Suppl 1):S35–41.CrossRefPubMed

45.•

Lavine SD, Cockroft K, Hoh B, et al. Training guidelines for endovascular ischemic stroke intervention: an international multi-society consensus document. AJNR Am J Neuroradiol. 2016. These are international expert group recommendations for endovascular stroke intervention training and skill maintance.

46.

Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet. 2014;384(9958):1929–35.CrossRefPubMedPubMedCentral

47.

Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA: J Am Med Assoc. 1999;282(21):2003–11.CrossRef

48.

Alexandrov AV, Molina CA, Grotta JC, et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med. 2004;351(21):2170–8.CrossRefPubMed

49.•

Menon BK, Campbell BC, Levi C, Goyal M. Role of imaging in current acute ischemic stroke workflow for endovascular therapy. Stroke; J Cereb Circ. 2015;46(6):1453–61. This highlights the role of advanced imaging in patient selection for endovascular intervention.CrossRef

50.

Powers WJ, Derdeyn CP, Biller J, et al. 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; J Cereb Circ. 2015;46(10):3020–35.CrossRef

51.

Casaubon LK, Boulanger JM, Blacquiere D, et al. Canadian stroke best practice recommendations: hyperacute stroke care guidelines, update 2015. Int J Stroke: Off J Int Stroke Soc. 2015;10(6):924–40.CrossRef

52.

Saqqur M, Uchino K, Demchuk AM, et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke; J Cereb Circ. 2007;38(3):948–54.CrossRef

53.

del Zoppo GJ, Poeck K, Pessin MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol. 1992;32(1):78–86.CrossRefPubMed

54.

Bhatia R, Shobha N, Menon BK, et al. Combined full-dose IV and endovascular thrombolysis in acute ischaemic stroke. Int J Stroke: Off J Int Stroke Soc. 2014;9(8):974–9.CrossRef

55.

Lemarchant S, Docagne F, Emery E, Vivien D, Ali C, Rubio M. tPA in the injured central nervous system: different scenarios starring the same actor? Neuropharmacology. 2012;62(2):749–56.CrossRefPubMed

56.

Yepes M, Roussel BD, Ali C, Vivien D. Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic. Trends Neurosci. 2009;32(1):48–55.CrossRefPubMed

57.

Kirkman MA, Lambden S, Smith M. Challenges in the anesthetic and intensive care management of acute ischemic stroke. J Neurosurg Anesthesiol 2015. 11 Sep 2015.

58.

Brinjikji W, Murad MH, Rabinstein AA, Cloft HJ, Lanzino G, Kallmes DF. Conscious sedation versus general anesthesia during endovascular acute ischemic stroke treatment: a systematic review and meta-analysis. AJNR Am J Neuroradiol. 2015;36(3):525–9.CrossRefPubMed

59.

Schonenberger S, Mohlenbruch M, Pfaff J, et al. Sedation vs. Intubation for Endovascular Stroke TreAtment (SIESTA)—a randomized monocentric trial. Int J Stroke: Off J Int Stroke Soc. 2015;10(6):969–78.CrossRef

60.

Sedation versus general anesthesia for endovascular therapy in acute stroke—impact on neurological outcome (ANSTROKE). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2015 Dec 17]. Available from: https://clinicaltrials.gov/ct2/show/NCT01872884.

61.

“GOLIATH”—General Or Local Anaestesia in Intra Arterial THerapy. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000 [cited 2015 Dec 17]. Available from: https://clinicaltrials.gov/ct2/show/NCT02317237.

62.

Steglich-Arnholm H, Holtmannspotter M, Kondziella D, et al. Thrombectomy assisted by carotid stenting in acute ischemic stroke management: benefits and harms. J Neurol. 2015;262(12):2668–75.CrossRefPubMed

63.

Han Z, Liu X, Luo Y, Ji X. Therapeutic hypothermia for stroke: where to go? Exp Neurol. 2015;272:67–77.CrossRefPubMed

64.

Herson PS, Traystman RJ. Animal models of stroke: translational potential at present and in 2050. Future Neurol. 2014;9(5):541–51.CrossRefPubMedPubMedCentral

65.

Hill MD, Martin RH, Mikulis D, et al. Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2012;11(11):942–50.CrossRefPubMed

66.

Saver JL, Starkman S, Eckstein M, et al. Prehospital use of magnesium sulfate as neuroprotection in acute stroke. N Engl J Med. 2015;372(6):528–36.CrossRefPubMedPubMedCentral

Titel: Endovascular Interventions in Acute Ischemic Stroke: Recent Evidence, Current Challenges, and Future Prospects
verfasst von: Ramana Appireddy
Charlotte Zerna
Bijoy K Menon
Mayank Goyal
Publikationsdatum: 01.07.2016
Verlag: Springer US
Erschienen in: Current Atherosclerosis Reports / Ausgabe 7/2016
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-016-0588-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Endovascular Interventions in Acute Ischemic Stroke: Recent Evidence, Current Challenges, and Future Prospects

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2016

Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity

Treatment of Isolated Below the Knee Deep Vein Thrombosis

Role of cis-Monounsaturated Fatty Acids in the Prevention of Coronary Heart Disease

How to Choose the Best Metabolic Procedure?

Discontinuation of Statins: What Are the Risks?

Duration of Dual Antiplatelet Therapy in Coronary Artery Disease: a Review Article

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin