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Brain Topography

Erschienen in:

17.05.2020 | Original Paper

Enhanced Regional Functional Connectivity Indicates Seizure Onset Zone

verfasst von: Jianpo Su, Nicolás von Ellenrieder, Dewen Hu, Jean Gotman

Erschienen in: Brain Topography | Ausgabe 4/2020

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Abstract

This project aims to explore if stronger functional connectivity (FC) exists in the maximal BOLD response of EEG/fMRI analysis when it is concordant with seizure-onset-zone (SOZ). Twenty-six patients with drug-resistant focal epilepsy who had an EEG/fMRI and later underwent stereo-EEG implantation were included. Different types of IEDs were labeled in scalp EEG and IED-related maximal BOLD responses were evaluated separately, each constituting one study. After evaluating concordance between maximal BOLD and SOZ, twenty-seven studies were placed in the concordant group and eight in the discordant group. We evaluated the local connectivity and ipsilaterally distant connectivity difference between the maximal BOLD and the contralateral homotopic region. Significantly stronger local FC was found for the maximal BOLD in the concordant group (p < 0.05, Bonferroni corrected). 52% of the studies in the concordant group and 13% in the discordant group had a significant difference compared to healthy subjects (p < 0.05, uncorrected). The finding suggests that, when concordant with the SOZ, the maximal BOLD is more likely to have stronger local FC compared to its contralateral counterpart. This asymmetry in functional connectivity may help to noninvasively improve the specificity of EEG/fMRI analysis.

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An D, Fahoum F, Hall J, Olivier A, Gotman J, Dubeau F (2013) Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy. Epilepsia 54(12):2184–2194. https://doi.org/10.1111/epi.12434 CrossRefPubMedPubMedCentral

Bartolomei F, Bettus G, Stam CJ, Guye M (2013) Interictal network properties in mesial temporal lobe epilepsy: a graph theoretical study from intracerebral recordings. Clin Neurophysiol 124(12):2345–2353. https://doi.org/10.1016/j.clinph.2013.06.003 CrossRefPubMed

Bettus G, Guedj E, Joyeux F, Confort-Gouny S, Soulier E, Laguitton V et al (2009) Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp 30(5):1580–1591. https://doi.org/10.1002/hbm.20625 CrossRefPubMed

Bettus G, Ranjeva J-P, Wendling F, Bénar CG, Confort-Gouny S, Régis J et al (2011) Interictal functional connectivity of human epileptic networks assessed by intracerebral EEG and BOLD signal fluctuations. PLoS ONE 6(5):e20071-e. https://doi.org/10.1371/journal.pone.0020071 CrossRef

Bettus G, Wendling F, Guye M, Valton L, Régis J, Chauvel P et al (2008) Enhanced EEG functional connectivity in mesial temporal lobe epilepsy. Epilepsy Res 81(1):58–68. https://doi.org/10.1016/j.eplepsyres.2008.04.020 CrossRefPubMed

Burns SP, Santaniello S, Yaffe RB, Jouny CC, Crone NE, Bergey GK et al (2014) Network dynamics of the brain and influence of the epileptic seizure onset zone. Proc Natl Acad Sci 111(49):E5321. https://doi.org/10.1073/pnas.1401752111 CrossRefPubMed

Centeno M, Tierney TM, Perani S, Shamshiri EA, St Pier K, Wilkinson C et al (2017) Combined electroencephalography–functional magnetic resonance imaging and electrical source imaging improves localization of pediatric focal epilepsy. Ann Neurol 82(2):278–287. https://doi.org/10.1002/ana.25003 CrossRefPubMed

Coutin-Churchman PE, Wu JY, Chen LLK, Shattuck K, Dewar S, Nuwer MR (2012) Quantification and localization of EEG interictal spike activity in patients with surgically removed epileptogenic foci. Clin Neurophysiol 123(3):471–485. https://doi.org/10.1016/j.clinph.2011.08.007 CrossRefPubMed

Dichter MA, Ayala GF (1987) Cellular mechanisms of epilepsy: a status report. Science 237(4811):157. https://doi.org/10.1126/science.3037700 CrossRefPubMed

Ebrahimzadeh E, Shams M, Fayaz F, Rajabion L, Mirbagheri M, Nadjar Araabi B et al (2019) Quantitative determination of concordance in localizing epileptic focus by component-based EEG-fMRI. Comput Methods Progr Biomed 177:231–241. https://doi.org/10.1016/j.cmpb.2019.06.003 CrossRef

Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM et al (2015) Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain 138(8):2249–2262. https://doi.org/10.1093/brain/awv130 CrossRefPubMedPubMedCentral

Greiner HM, Horn PS, Tenney JR, Arya R, Jain SV, Holland KD et al (2016) Preresection intraoperative electrocorticography (ECoG) abnormalities predict seizure-onset zone and outcome in pediatric epilepsy surgery. Epilepsia 57(4):582–589. https://doi.org/10.1111/epi.13341 CrossRefPubMed

Hall JA, Khoo HM (2017) Robotic-assisted and image-guided MRI-compatible stereoelectroencephalography. Can J Neurol Sci 45(1):35–43. https://doi.org/10.1017/cjn.2017.240 CrossRef

Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2):825–841. https://doi.org/10.1006/nimg.2002.1132 CrossRefPubMed

Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5(2):143–156. https://doi.org/10.1016/S1361-8415(01)00036-6 CrossRefPubMed

Kandel ER, Schwartz JH, Jessell TM, Do B, Jessell MBT, Siegelbaum S et al (2000) Principles of neural science. McGraw-hill, New York

Khoo HM, Hao Y, Ellenrieder N, Zazubovits N, Hall J, Olivier A et al (2017) The hemodynamic response to interictal epileptic discharges localizes the seizure-onset zone. Epilepsia 58(5):811–823. https://doi.org/10.1111/epi.13717 CrossRefPubMed

Khoo HM, von Ellenrieder N, Zazubovits N, He D, Dubeau F, Gotman J (2018) The spike onset zone: the region where epileptic spikes start and from where they propagate. Neurology. https://doi.org/10.1212/WNL.0000000000005998 CrossRefPubMedPubMedCentral

Lee HW, Arora J, Papademetris X, Tokoglu F, Negishi M, Scheinost D et al (2014) Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity. Neurology 83(24):2269. https://doi.org/10.1212/WNL.0000000000001068 CrossRefPubMedPubMedCentral

Liao W, Zhang Z, Pan Z, Mantini D, Ding J, Duan X et al (2010) Altered functional connectivity and small-world in mesial temporal lobe epilepsy. PLoS ONE 5(1):e8525. https://doi.org/10.1371/journal.pone.0008525 CrossRefPubMedPubMedCentral

Mercier L, Del Maestro RF, Petrecca K, Kochanowska A, Drouin S, Yan CXB et al (2011) New prototype neuronavigation system based on preoperative imaging and intraoperative freehand ultrasound: system description and validation. Int J Comput Assist Radiol Surg 6(4):507–522. https://doi.org/10.1007/s11548-010-0535-3 CrossRefPubMed

Mueller S, Wang D, Fox Michael D, Yeo BTT, Sepulcre J, Sabuncu Mert R et al (2013) Individual variability in functional connectivity architecture of the human brain. Neuron 77(3):586–595. https://doi.org/10.1016/j.neuron.2012.12.028 CrossRefPubMedPubMedCentral

Negishi M, Martuzzi R, Novotny EJ, Spencer DD, Constable RT (2011) Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia 52(9):1733–1740. https://doi.org/10.1111/j.1528-1167.2011.03191.x CrossRefPubMedPubMedCentral

Olivier A, Germano IM, Cukiert A, Peters T (1994) Frameless stereotaxy for surgery of the epilepsies: preliminary experience. J Neurosurg 81(4):629–633. https://doi.org/10.3171/jns.1994.81.4.0629 CrossRefPubMed

Pereira FRS, Alessio A, Sercheli MS, Pedro T, Bilevicius E, Rondina JM et al (2010) Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. Bmc Neurosci 11(1):66. https://doi.org/10.1186/1471-2202-11-66 CrossRefPubMedPubMedCentral

Pittau F, Dubeau F, Gotman J (2012) Contribution of EEG/fMRI to the definition of the epileptic focus. Neurology 78(19):1479. https://doi.org/10.1212/WNL.0b013e3182553bf7 CrossRefPubMedPubMedCentral

Ridley B, Wirsich J, Bettus G, Rodionov R, Murta T, Chaudhary U et al (2017) Simultaneous intracranial EEG-fMRI shows inter-modality correlation in time-resolved connectivity within normal areas but not within epileptic regions. Brain Topogr 30(5):639–655. https://doi.org/10.1007/s10548-017-0551-5 CrossRefPubMed

Schevon CA, Cappell J, Emerson R, Isler J, Grieve P, Goodman R et al (2007) Cortical abnormalities in epilepsy revealed by local EEG synchrony. Neuroimage 35(1):140–148. https://doi.org/10.1016/j.neuroimage.2006.11.009 CrossRefPubMedPubMedCentral

Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BTT, Buckner RL (2010) The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol 6(6):e1000808. https://doi.org/10.1371/journal.pcbi.1000808 CrossRefPubMedPubMedCentral

Spanedda F, Cendes F, Gotman J (1997) Relations between EEG seizure morphology, interhemispheric spread, and mesial temporal atrophy in bitemporal epilepsy. Epilepsia 38(12):1300–1314. https://doi.org/10.1111/j.1528-1157.1997.tb00068.x CrossRefPubMed

Steven MS, Hesheng L, Jorge S, Naoaki T, Randy LB, Joseph RM (2011) Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg JNS 114(6):1693–1697. https://doi.org/10.3171/2011.1.JNS10482 CrossRef

Su J, Khoo HM, von Ellenrieder N, Zeng L-L, Hu D, Dubeau F et al (2019) fMRI functional connectivity as an indicator of interictal epileptic discharges. NeuroImage: Clin 24:102038. https://doi.org/10.1016/j.nicl.2019.102038 CrossRef

Van Essen DC, Smith SM, Barch DM, Behrens TEJ, Yacoub E, Ugurbil K (2013) The WU-Minn Human Connectome Project: an overview. Neuroimage 80:62–79. https://doi.org/10.1016/j.neuroimage.2013.05.041 CrossRefPubMedPubMedCentral

Weaver K, Chaovalitwongse W, Novotny E, Poliakov A, Grabowski T, Ojemann J (2013) Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion. Front Neurol, Focal Epilepsy. https://doi.org/10.3389/fneur.2013.00043 CrossRef

Worsley KJ, Liao CH, Aston J, Petre V, Duncan GH, Morales F et al (2002) A general statistical analysis for fMRI data. Neuroimage 15(1):1–15. https://doi.org/10.1006/nimg.2001.0933 CrossRefPubMed

Zeng L-L, Shen H, Liu L, Hu D (2014a) Unsupervised classification of major depression using functional connectivity MRI. Hum Brain Mapp 35(4):1630–1641. https://doi.org/10.1002/hbm.22278 CrossRefPubMed

Zeng L-L, Wang D, Fox MD, Sabuncu M, Hu D, Ge M et al (2014b) Neurobiological basis of head motion in brain imaging. Proc Natl Acad Sci USA 111(16):6058–6062. https://doi.org/10.1073/pnas.1317424111 CrossRefPubMed

Zeng L-L, Wang H, Hu P, Yang B, Pu W, Shen H et al (2018) Multi-site diagnostic classification of schizophrenia using discriminant deep learning with functional connectivity MRI. EBioMedicine 30:74–85. https://doi.org/10.1016/j.ebiom.2018.03.017 CrossRefPubMedPubMedCentral

Titel: Enhanced Regional Functional Connectivity Indicates Seizure Onset Zone
verfasst von: Jianpo Su
Nicolás von Ellenrieder
Dewen Hu
Jean Gotman
Publikationsdatum: 17.05.2020
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 4/2020
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-020-00775-4

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