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Journal of Nephrology

Erschienen in:

01.12.2018 | Review

Epicardial adipose tissue: new parameter for cardiovascular risk assessment in high risk populations

verfasst von: Roberta Russo, Biagio Di Iorio, Luca Di Lullo, Domenico Russo

Erschienen in: Journal of Nephrology | Ausgabe 6/2018

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Abstract

Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechanisms. Cytokines from peri-adventitial EAT may pass through the coronary wall by diffusion from the outside to the inside, interacting with cells. An additional potential mechanism by which EAT interacts locally with coronary arteries may be the vasocrine secretion.EAT may play a significant role as a modulator of cardiac functions. In physiologic conditions, EAT has biochemical cardio-protective properties, secreting anti-atherosclerosis substances; in metabolic disease states, EAT secretes bioactive molecules that may play an important role in the pathogenesis of coronary artery disease and cardiac arrhythmias by promoting atherosclerosis. EAT has been evaluated both in the general population and in metabolic disease states that are characterized by inflammation, such as cardiovascular diseases and chronic kidney disease.This review focuses on the current state of knowledge on EAT as a reliable new parameter for cardiovascular risk stratification in high risk populations.

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Titel: Epicardial adipose tissue: new parameter for cardiovascular risk assessment in high risk populations
verfasst von: Roberta Russo
Biagio Di Iorio
Luca Di Lullo
Domenico Russo
Publikationsdatum: 01.12.2018
Verlag: Springer International Publishing
Erschienen in: Journal of Nephrology / Ausgabe 6/2018
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI: https://doi.org/10.1007/s40620-018-0491-5

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