Background
Methods
Experimental ethics
Collection of data and cytological analysis
Histo-pathological analysis
HPV genotyping
Statistical analysis
Results
Population characteristics
Overall | Central | North-west | North-east | South-west | South-east | |
---|---|---|---|---|---|---|
(n = 17898) | (n = 7065) | (n = 3772) | (n = 3152) | (n = 2164) | (n = 1745) | |
Normal | 16968 (94.8) | 6704 (94.9) | 3570 (94.6) | 2984 (94.7) | 2062 (95.3) | 1648 (94.4) |
CINI | 458 (2.5) | 173 (2.4) | 97 (2.8) | 85 (2.7) | 51 (2.3) | 52 (3.0) |
CINII | 247 (1.4) | 103 (1.4) | 56 (1.5) | 40 (1.3) | 23 (1.1) | 25 (1.4) |
CINIII | 181 (1.0) | 64 (0.9) | 37 (1.0) | 36 (1.1) | 25 (1.5) | 19 (1.1) |
CC | 44 (0.2) | 21 (0.3) | 12 (0.3) | 7 (0.2) | 3 (0.1) | 1 (0.05) |
Ethnic | ||||||
Han | 13465 (75.2) | 5499 (77.8) | 2841 (75.3) | 2157 (68.4) | 1658 (76.6) | 1310 (75.1) |
Others | 4433 (24.8) | 1566 (22.2) | 931 (24.7) | 995 (31.6) | 506 (23.4) | 435 (24.9) |
Area | ||||||
Rural | 6849 (38.3) | 2695 (38.1) | 1462 (38.8) | 1176 (37.3) | 820 (37.9) | 696 (39.9) |
Urban | 11049 (61.7) | 4370 (61.9) | 2310 (61.2) | 1976 (62.7) | 1344 (62.1) | 1049 (60.1) |
Education | ||||||
Graduate | 4399 (24.6) | 1780 (25.2) | 897 (23.8) | 847 (26.9) | 422 (19.5) | 453 (25.9) |
High | 3841 (21.5) | 1533 (21.7) | 845 (22.4) | 684 (21.7) | 408 (18.8) | 371 (21.3) |
Middle | 5564 (31.1) | 2282 (32.3) | 1114 (29.5) | 892 (28.3) | 733 (33.9) | 543 (31.1) |
Primary | 2370 (13.2) | 807 (11.4) | 515 (13.6) | 368 (11.3) | 481 (22.2) | 199 (11.4) |
Illiterate | 1724 (9.6) | 663 (9.4) | 401 (10.6) | 361 (11.4) | 120 (5.5) | 179 (10.2) |
Profession | ||||||
Farmer | 3886 (21.7) | 1321 (18.7) | 730 (19.3) | 643 (20.4) | 663 (30.7) | 529 (30.3) |
Government | 3489 (19.5) | 1407 (19.9) | 663 (17.6) | 602 (19.1) | 496 (22.9) | 321 (18.4) |
Others | 2410 (13.5) | 968 (13.7) | 547 (14.5) | 351 (11.1) | 307 (14.2) | 237 (13.4) |
Private | 3918 (21.9) | 1613 (22.8) | 882 (23.4) | 704 (22.3) | 381 (17.6) | 338 (19.4) |
Services | 2689 (15.9) | 1141 (16.1) | 619 (16.4) | 497 (15.8) | 253 (11.7) | 179 (10.2) |
No work | 1506 (8.4) | 615 (7.8) | 331 (8.8) | 355 (11.3) | 64 (2.9) | 141 (8.1) |
Smoke | ||||||
Yes | 7619 (42.6) | 2981 (42.2) | 1565 (41.5) | 1409 (44.7) | 903 (41.7) | 761 (43.6) |
No | 10279 (57.4) | 4084 (57.8) | 2207 (58.5) | 1743 (55.3) | 1261 (58.3) | 984 (56.4) |
Drinking | ||||||
Yes | 11203 (62.6) | 4759 (67.4) | 1613 (42.8) | 2183 (69.2) | 1469 (67.9) | 1179 (67.6) |
No | 6695 (37.4) | 2306 (32.6) | 2159 (57.2) | 969 (30.7) | 695 (32.1) | 566 (32.4) |
Material status | ||||||
Married | 14675 (82.0) | 5921 (83.3) | 3078 (81.6) | 2478 (78.6) | 1799 (83.1) | 1399 (80.2) |
Single | 3223 (18.0) | 1144 (16.2) | 694 (18.4) | 674 (21.3) | 365 (16.9) | 346 (19.8) |
Pregnancy | ||||||
Single | 10334 (57.7) | 4511 (63.8) | 2033 (53.9) | 1653 (52.4) | 1187 (54.8) | 950 (54.4) |
Multiple | 7564 (42.3) | 2554 (36.2) | 1739 (46.1) | 1499 (47.5) | 977 (45.1) | 795 (45.4) |
Age groups | ||||||
<35 years | 6582 (36.8) | 2779 (39.3) | 1452 (38.5) | 1092 (34.6) | 759 (35.1) | 500 (28.6) |
36–45 | 6941 (38.9) | 3195 (45.3) | 957 (25.4) | 1115 (35.4) | 710 (32.8) | 964 (55.2) |
>46 years | 4375 (24.4) | 1091 (15.4) | 1363 (36.1) | 945 (30.0) | 695 (32.1) | 281 (16.1) |
HPV genotype distribution by region
Variable | Overall | Central | North-east | North-west | South-east | South-west |
P-Value |
---|---|---|---|---|---|---|---|
(n = 17898) |
n = 7065 |
n = 3152 |
n = 3772 |
n = 1745 |
n = 2164 | ||
Overalla
| 14.0 (13.5–14.5 | 12.9 (12.1–13.7) | 11.1 (10.0–12.2) | 18.0 (16.8–19.2) | 13.3 (11.7–14.9) | 19.9 (18.2–21.6) | 0.001 |
High riska
| 12.2 (–11.7–12.7) | 10.5 (9.8–11.2) | 9.6 (8.6–10.6) | 13.9 (12.0–14.2) | 11.6 (10.1–13.1) | 18.1 (16.5–19.7) | 0.001 |
Othersa
| 1.8 (1.6–2.0) | 2.4 (2.04–2.7) | 1.5 (1.1–1.9) | 4.1 (3.5–4.7) | 1.7 (1.1–2.3) | 1.3 (0.8–1.8) | 0.001 |
Single infectiona
| 11.0 (10.5–11.4) | 10.0 (9.3–10.7) | 9.1 (8.1–10.1) | 11.3 (10.3–12.3) | 10.5 (9.1–11.9) | 16.7 ((15.1–18.3) | 0.001 |
Multiple infectiona
| 3.0 (2.8–3.2) | 2.9 (2.5–3.3) | 2.0 (1.5–2.5) | 4.2 (3.6–4.8) | 2.7 (1.9–3.5) | 3.1 (2.4–3.8) | 0.001 |
Unidentifieda
| 1.1 (0.9–1.2) | 0.7 (0.5–0.9) | 0.8 (0.5–1.1) | 2.2 (1.7–2.7) | 0.9 (0.5–1.3) | 0.9 (0.5–1.3) | 0.009 |
HR-HPV | |||||||
HPV-52a
| 3.1 (2.9–3.3) | 3.4 (3.0–3.8) | 2.4 (1.9–2.9) | 3.3 (2.7–3.9) | 3.0 (2.2–3.8) | 3.1 (2.4–3.8) | 0.15 |
HPV-16a
| 3.4 (3.1–3.7) | 3.0 (2.8–3.2) | 2.4 (1.9–2.9) | 3.5 (2.9–4.1) | 3.4 (2.5–4.2) | 5.9 (4.9–6.9) | 0.001 |
HPV-58a
| 2.1 (1.9–2.3) | 1.9 (1.6–2.2) | 1.4 (1.0–1.8) | 2.3 (1.8–2.8) | 1.5 (0.9–2.1) | 3.5 (2.7–4.3) | 0.001 |
HPV-18a
| 1.2 (1.0–1.3) | 1.1 (0.9–1.3) | 1.4 (1.0–1.8) | 1.4 (1.0–1.8) | 13 (0.7) | 1.5 (1.0–2.0) | 0.16 |
HPV-51 | 120 (0.7) | 49 (0.7) | 18 (0.6) | 23 (0.6) | - | 30 (1.4) | 0.2 |
HPV-39 | 118 (0.6) | 45 (0.6) | 13 (0.4) | 34 (0.9) | 17 (1.0) | 9 (0.4) | 0.69 |
HPV-33 | 124 (0.7) | 44 (0.6) | 20 (0.6) | 52 (1.4) | - | 8 (0.4) | 0.35 |
HPV-68 | 122 (0.7) | 43 (0.6) | 19 (0.6) | 31 (0.8) | 9 (0.5) | 20 (0.9) | |
HPV-56 | 60 (0.3) | 32 (0.4) | 4 (0.1) | 8 (0.2) | 8 (0.4) | 8 (0.4) | |
HPV-59 | 56 (0.3) | 27 (0.4) | 3 (0.1) | 19 (0.5) | 5 (0.3) | 2 (0.09) | |
HPV-31 | 63 (0.3) | 23 (0.3) | 9 (0.3) | 11 (0.3) | 7 (0.4) | 13 (0.6) | |
HPV-35 | (12) 0.07 | 7 (0.01) | 5 (0.1) | - | - | - | |
HPV-45 | 12 (0.07) | 3 (0.04) | 5 (0.1) | - | 4 (0.2) | - | |
PHR-HPV | |||||||
HPV-53 | 176 (1.0) | 75 (1.1) | 33 (1.0) | 32 (0.8) | 25 (1.4) | 11 (0.5) | |
HPV-81 | 108 (0.6) | 42 (0.6) | 12 (0.4) | 23 (0.6) | 13 (0.7) | 18 (0.8) | |
HPV-66 | 15 (0.2) | 9 (0.3) | 16 (0.4) | 10 (0.6) | 18 (0.8) | ||
LR-HPV | |||||||
HPV-11 | 68 (0.4) | 14 (0.2) | - | 7 (0.2) | 6 (0.3) | 5 (0.2) | |
HPV-6 | 16 (0.09) | 9 (0.1) | - | 4 (0.1) | 3 (0.2) | - | |
HPV-61 | 30 (0.2) | - | 9 (0.3) | 5 (0.1) | 7 (0.4) | 9 (0.4) | |
HPV-43 | 15 (0.08) | 7 (0.1) | - | - | - | 8 (0.4) | |
HPV-55 | 7 (0.04) | 6 (0.08) | 1 (0.03) | - | - | - | |
HPV-44 | 12 (0.07) | 5 (0.07) | - | - | - | 7 (0.3) | |
HPV-42 | 9 (0.05) | 4 (0.06) | - | - | 3 (0.2) | 2 (0.09) | |
HPV-40 | 4 (0.02) | - | 4 (0.1) | - | - | - | |
HPV-67 | 1 (0.005) | - | 1 (0.03) | - | - | - | |
HPV-69 | 1 (0.005) | - | 1 (0.03) | - | - | - | |
HPV-70 | 2 (0.01) | 2 (0.03) | - | - | - | - | |
HPV-71 | 3 (0.002) | 3 (0.04) | - | - | - | - | |
HPV-82 | 6 (0.03) | 1 (0.02) | - | - | 2 (0.1) | 3 (0.1) | |
HPV-83 | 2 (0.01) | - | - | 1 (0.02) | - | 1 (0.05) |
HPV genotypes and histo-pathological grades
Variable | Normal | CIN1 | CIN2 | CIN3 | SCC |
P-Value |
---|---|---|---|---|---|---|
(n = 16968) | (n = 458) | (n = 247) | (n = 181) | (n = 44) | ||
overalla
| 10.0 (9.5–10.4) | 81.2 (77.6–84.8) | 86.2 (81.9–90.5) | 94.5 (91.2–97.8) | 95.4 | 0.001 |
High riska
| 9.1 (8.7–9.5) | 64.0 (59.6–68.4) | 65.2 (59.3–71.1) | 80.1 (74.3–85.9) | 88.6 (79.2–98.0) | 0.001 |
Othersa
| 166 (1.0) | 17.2 (13.8–20.6) | 21.0 (15.9–26.1) | 14.4 (9.3–19.5) | 6.8 | 0.17 |
Singlea infectiona
| 8.3 (7.9–8.7) | 56.8 (51.9–60.9) | 55.5 (49.3–61.7) | 72.4 (65.9–78.9) | 77.3 (64.9–89.7) | 0.001 |
Multiple infectiona
| 1.8 (1.6–2.0) | 24.4 (20.5–28.3) | 30.8 (25.1–36.5) | 22.1 (16.1–28.1) | 18.2 (6.8–29.6) | 0.5 |
Unidentifieda
| 0.7 | 7.0 (4.7–9.3) | 8.1 (4.7–11.5) | 6.6 (3.0–10.2) | 9.1 (0.6–17.6) | |
HR-HPV | ||||||
HPV-16a
| 2.2 (1.9–2.4) | 21.0 (17.3–24.7) | 16.2 (11.6–20.8) | 33.1 (26.3–39.9) | 45.4 (30.7–60.1) | 0.001 |
HPV-52a
| 2.3 (2.1–2.5) | 20.1 (16.4–23.8) | 19.4 (14.5–24.3) | 11.0 (6.5–15.5) | 15.9 (5.1–26.7) | 0.025 |
HPV-58a
| 1.4 | 13.1 (10.0–16.2) | 14.6 (10.2–20.0) | 19.9 (14.1–25.7) | 18.2 (6.8–29.6) | 0.04 |
HPV-18a
| 0.6 | 5.2 (3.2–7.2) | 1.6 (0.03–3.2) | 17.7 (12.1–23.3) | 18.2 (6.8–29.6) | 0.001 |
HPV-51 | 92 (0.5) | 16 (3.5) | 12 (4.8) | - | - | |
HPV-68 | 84 (0.5) | 23 (5.0) | 8 (3.2) | 7 (3.9) | - | |
HPV-33 | 80 (0.5) | 20 (4.4) | 20 (8.1) | 4 (2.2) | - | |
HPV-39 | 76 (0.4) | 28 (6.1) | 8 (3.2) | 4 (2.2) | - | |
HPV-31 | 48 (0.3) | 6 (1.3) | 4 (1.6) | 5 (2.8) | - | |
HPV-56 | 40 (0.2) | 8 (1.7) | 8 (3.2) | 4 (2.2) | - | |
HPV-59 | 40 (0.2) | 8 (1.7) | - | 4 (2.2) | 4 (9.1) | |
HPV-45 | 4 (0.02) | 6 (1.3) | - | 2 (1.1) | - | |
HPV-35 | 9 (0.05) | 3 (0.6) | - | - | - | |
PHR-HPV | ||||||
HPV-53 | 128 (0.7) | 28 (6.1) | 20 (8.1) | - | - | |
HPV-81 | 52 (0.3) | 24 (5.2) | 19 (7.7) | 12 (6.6) | - | |
HPV-66 | 44 (0.2) | 8 (1.7) | 8 (3.2) | 4 (2.2) | 3 (6.8) | |
Others | ||||||
HPV-61 | 24 (0.1) | - | 3 (1.2) | - | - | |
HPV-11 | 24 (0.1) | - | 4 (1.6) | 4 (2.2) | - | |
HPV-6 | 12 (0.07) | - | - | 4 (2.2) | - | |
HPV-43 | 8 (0.05) | 4 (0.9) | - | 3 (1.6) | - | |
HPV-44 | 8 (0.05) | 4 (0.9) | - | - | - | |
HPV-42 | 4 (0.02) | 2 (0.4) | - | 3 (1.6) | - | |
HPV-55 | 4 (0.02) | 3 (0.6) | - | - | - | |
HPV-40 | 4 (0.02) | - | - | - | - | |
HPV-67 | 1 (0.005) | - | - | - | - | |
HPV-69 | 1 (0.005) | - | - | - | - | |
HPV-70 | 2 (0.01) | - | - | - | - | |
HPV-71 | 3 (0.01) | - | - | - | - | |
HPV-82 | 6 (0.03) | - | - | - | - | |
HPV-83 | 2 (0.01) | - | - | - | - |
HPV genotypes and infection
Single infection | Multiple infection | |||||
---|---|---|---|---|---|---|
Variable | Normal | Abnormal |
P-value | Control | Abnormal |
P-value |
(n = 16968) | (n = 930) | (n = 16968) | (n = 930) | |||
Overalla
| 8.3 (7.9–8.7) | 60.4 (58.8–62.0) | 0.001 | 1.8 (1.6–2.0) | 25.4 (22.6–28.2) | 0.001 |
Unidentifieda
| 0.7 (0.6–0.8) | 7.3 (5.6–9.0) | 0.001 | - | - | |
HPV-16a
| 1.6 (1.4–1.8) | 14.6 (12.3–16.9) | 0.001 | 0.6 (0.5–0.7) | 9.9 (8.0–11.8) | 0.001 |
HPV-52a
| 1.6 (1.4–1.8) | 10.3 (8.4–12.2) | 0.001 | 0.6 (0.5–0.7) | 7.7 (6.0–9.4) | 0.001 |
HPV-58a
| 0.9 (0.8–1.0) | 9.5 (7.6–11.4) | 0.001 | 0.5 (0.4–0.6) | 5.6 (4.1–7.1) | 0.001 |
HPV-18 | 84 (0.5) | 48 (5.2) | 0.001 | 52 (0.3) | 36 (3.9) | 0.001 |
HPV-68 | 52 (0.3) | 10 (1.1) | 0.002 | 32 (0.2) | 28 (3.0) | 0.001 |
HPV-51 | 52 (0.3) | 8 (0.9) | 0.012 | 40 (0.2) | 20 (2.1) | 0.001 |
HPV-33 | 48 (0.3) | 36 (3.9) | 0.001 | 32 (0.2) | 8 (0.9) | 0.01 |
HPV-39 | 48 (0.3) | 12 (1.3) | 0.001 | 28 (0.2) | 28 (3.0) | 0.001 |
HPV-31 | 36 (0.2) | 3 (0.3) | 0.45 | 12 (0.07) | 12 (1.3) | 0.001 |
HPV-59 | 28 (0.2) | 12 (1.3) | 0.001 | 12 (0.07) | 4 (0.4) | 0.008 |
HPV-56 | 20 (0.1) | - | 20 (0.1) | 16 (1.7) | 0.001 | |
HPV-45 | 4 (0.02) | - | - | 8 (0.9) | ||
HPV-35 | 3 (0.02) | - | 6 (0.03) | 3 (0.3) | 0.008 | |
PHR-HPV | ||||||
HPV-53 | 88 (0.5) | 24 (2.6) | 0.001 | 40 (0.2) | 24 (2.6) | 0.001 |
HPV-66 | 24 (0.1) | 3 (0.3) | 0.16 | 20 (0.1) | 20 (2.1) | 0.001 |
HPV-81 | 20 (0.1) | 11 (1.2) | 0.001 | 32 (0.2) | 44 (4.7) | 0.001 |
LR-HPV | ||||||
HPV-61 | 24 (0.1) | 3 (0.3) | 0.16 | - | - | |
HPV-11 | - | - | 24 (0.1) | 8 (0.9) | 0.001 | |
HPV-6 | - | - | 12 (0.07) | 4 (0.4) | 0.008 | |
HPV-42 | - | - | 5 (0.03) | 4 (0.4) | 0.001 | |
HPV-55 | 4 (0.02) | 3 (0.3) | - | - | ||
HPV-40 | 4 (0.02) | - | - | |||
HPV-44 | 4 (0.02) | - | 4 (0.02) | 4 (0.4) | 0.001 | |
HPV-43 | 3 (0.01) | - | 4 (0.02) | 8 (0.9) | 0.001 | |
Unclassified | ||||||
HPV-82 | 7 (0.04) | - | - | - | ||
HPV-71 | 3 (0.02) | - | - | - | ||
HPV-70 | 2 (0.01) | - | - | - | ||
HPV-83 | 2 (0.01) | - | - | - | ||
HPV-67 | 1 (0.005) | - | - | - | ||
HPV-69 | 1 (0.005) | - | - | - |
Normal cases | Histo-pathologically abnormal cases | |||||||
---|---|---|---|---|---|---|---|---|
Variables | >35 years (N = 5978) | 36–45 years (n = 6534) | <46 years (n = 4456) |
P-value | >35 years (n = 326) | 36–45 years (n = 318) | <46 years (n = 286) |
P-Value |
Overall | 721 (12.1) | 592 (9.1) | 443 (9.9) | 0.001 | 290 (88.9) | 235 (73.9) | 273 (95.4) | 0.045 |
Single | 579 (9.7) | 502 (7.7) | 321 (7.2) | 0.001 | 207 (63.5) | 171 (53.8) | 184 (64.3) | 0.9 |
Multiple | 142 (2.4) | 90 (1.4) | 122 (2.7) | 0.44 | 83 (25.5) | 64 (20.1) | 89 (31.2) | 0.13 |
HR-HPV | 1087 | |||||||
HPV-16 | 160 (2.7) | 132 (2.0) | 88 (2.0) | 0.018 | 100 (30.7) | 80 (25.1) | 48 (16.8) | 0.001 |
HPV-52 | 153 (2.5) | 119 (1.8) | 120 (2.7) | 0.003 | 63 (19.3) | 61 (19.2) | 16 (5.6) | 0.001 |
HPV-58 | 98 (1.6) | 69 (1.0) | 65 (1.4) | 0.016 | 52 (15.5) | 80 (25.1) | 36 (12.6) | 0.37 |
HPV-18 | 64 (1.1) | 41 (0.6) | 31 (0.7) | 0.022 | 22 (6.7) | 37 (11.6) | 25 (8.7) | 0.35 |
HPV-68 | 40 (0.7) | 31 (0.5) | 13 (0.3) | 0.024 | 10 (3.1) | 25 (7.9) | 3 (1.0) | 0.27 |
HPV-33 | 44 (0.7) | 24 (0.4) | 12 (0.3) | 0.001 | 20 (6.1) | 24 (7.5) | - | |
HPV-51 | 29 (0.5) | 43 (0.6) | 20 (0.4) | 0.25 | 12 (3.7) | 16 (5.0) | - | |
HPV-56 | 12 (0.2) | 16 (0.2) | 10 (0.2) | 0.87 | 8 (2.4) | - | 8 (2.8) | |
HPV-31 | 10 (0.2) | 15 (0.2) | 23 (0.5) | 0.002 | 8 (2.4) | 6 (1.9) | 1 (0.3) | |
HPV-59 | 10 (0.2) | 21 (0.3) | 9 (0.2) | 5 (1.5) | 3 (0.9) | 8 (2.8) | ||
HPV-39 | 8 (0.1) | 32 (0.5) | 16 (0.3) | 8 (2.4) | 18 (5.7) | 14 (4.9) | ||
HPV-35 | 4 (0.07) | 2 (0.03) | 3 (0.07) | - | 3 (0.9) | - | ||
HPV-45 | 1 (0.02) | 3 (0.04) | - | 2 (0.6) | - | 6 (2.1) | ||
PHR-HPV | 132 | |||||||
HPV-53 | 28 (0.5) | 56 (0.8) | 44 (1.0) | 0.003 | 16 (4.9) | 16 (5.0) | 16 (5.6) | 0.7 |
HPV-66 | 23 (0.4) | 11 (0.2) | 10 (0.2) | 0.05 | 13 (4.0) | 6 (1.9) | 4 (1.4) | |
HPV-81 | 20 (0.3) | 12 (0.2) | 20 (0.4) | 0.042 | - | 22 (6.9) | 15 (5.2) | |
Others | 183 | - | - | - | ||||
HPV-83 | - | 2 (0.03) | - | - | - | - | ||
HPV-69 | - | 1 (0.01) | - | - | - | - | ||
HPV-70 | - | 2 (0.03) | - | - | - | - | ||
HPV-71 | - | - | 3 (0.07) | - | - | - | ||
HPV-82 | 4 (0.05) | - | 3 (0.07) | - | - | - | ||
HPV-67 | 1 (0.02) | - | - | - | - | - | ||
HPV-61 | 11 (0.2) | 7 (0.1) | 6 (0.1) | 0.5 | 3 (0.9) | - | - | |
HPV-11 | 10 (0.2) | 7 (0.1) | 7 (0.1) | 0.63 | - | - | 8 (2.8) | |
HPV-6 | 5 (0.08) | 7 (0.1) | - | - | - | 4 (1.4) | ||
HPV-40 | 4 (0.07) | - | - | |||||
HPV-44 | 4 (0.07) | 4 (0.06) | - | - | 4 (1.2) | - | ||
HPV-43 | 2 (0.03) | - | 5 (0.1) | - | 3 (0.9) | 5 (1.7) | ||
HPV-42 | 1 (0.02) | 3 (0.04) | 1 (0.02) | - | 4 (1.2) | - | ||
HPV-55 | - | 4 (0.06) | - | - | 3 (0.9) | - | ||
Unidentified | 44 (0.7) | 76 (1.2) | 8 (0.2) | 0.001 | 28 (8.6) | 32 (10.1) | 8 (2.8) | 0.008 |