Discussion
Creatinine clearance (CrCl) (mL/min/1.73 m2) | 52.1 ± 25.8 |
Iothalamate measured glomerular filtration rate (iGFR) (mL/min/1.73 m2) | 48.0 ± 19.9 |
CrCl/iGFR, mean ± SD | 1.13 ± 0.46 |
CrCl/iGFR, median (25th-75th percentile) | 1.09 (0.88-1.32) |
Laboratory results | |
Serum creatinine (mg/dL) | 1.70 ± 0.56 |
Quintiles of iGFR (ml/s/1.73 m2) | iGFR (ml/min/1.73 m2), median (IQR) | CrCl (ml/min/1.73 m2), median (IQR) | CrCl/iGFR, median (IQR) |
---|---|---|---|
1 (N = 269) | 24.8 (20.8—27.4) | 30.1 (24.0—37.3) | 1.26 (1.01—1.54) |
2 (N = 268) | 35.7 (33.0—38.5) | 40.3 (32.0—48.8) | 1.14 (0.89—1.40) |
3 (N = 269) | 45.7 (43.3—48.0) | 49.8 (39.1—58.2) | 1.09 (0.88—1.26) |
4 (N = 268) | 56.3 (53.1—59.8) | 58.8 (47.6—69.4) | 1.04 (0.83—1.22) |
5 (N = 268) | 74.7 (68.4—84.9) | 77.8 (61.8—91.8) | 1.00 (0.82—1.16) |
Normal (24-hrs urine albumin < 30 mg; N = 515) | Microalbuminuria (24-hrs urine albumin 30 to ≦299 mg; N = 343) | Macroalbuminuria (24-hrs urine albumin 300 to ≦2999 mg; N = 378) | Nephrotic-range proteinuria (24-hrs urine albumin ≧3000 mg; N = 106) | |
---|---|---|---|---|
Absolute change in CrCl/iGFR (95% CI) | ||||
Unadjusted | reference | 0.05 (−0.01—0.11) P = 0.12 | 0.02 (−0.04—0.08) P = 0.48 | 0.06 (−0.03—0.16) P = 0.20 |
Multivariate adjusteda
| reference | 0.06 (−0.01—0.12) P = 0.08 | 0.04 (−0.02—0.11) P = 0.21 | 0.10 (−0.01—0.21) P = 0.07 |
Non-Hispanic white (N = 568) | Non-Hispanic black (N = 494) | Hispanics (N = 188) | Others (N = 92) | |
---|---|---|---|---|
Absolute change in CrCl/iGFR ratio (95% CI) | ||||
Unadjusted | reference | −0.03 (−0.08—0.03) P = 0.34 | 0.01(−0.07—0.08) P = 0.89 | −0.01 (−0.12—0.09) P = 0.79 |
Multivariate adjusteda
| reference | −0.03 (−0.08—0.03) P = 0.38 | 0.01 (−0.06—0.09) P = 0.72 | 0.01 (−0.10—0.11) P = 0.91 |