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Erschienen in: EJNMMI Research 1/2017

Open Access 01.12.2017 | Erratum

Erratum to: Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer's disease

verfasst von: Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard, Suzanne Reeves

Erschienen in: EJNMMI Research | Ausgabe 1/2017

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The online version of the original article can be found under doi:10.​1186/​s13550-016-0226-3.

Erratum

Following publication of the original article [1] the authors contacted the team with the request that some additional information be added to the article. Please see below for details:
Additional Table: absolute variability
Variability (VAR) presented in the main article represents mean variability between test and retest, not absolute variability as stated. The authors would like to apologise for this error. The absolute variability is presented in the table below has been calculated in the following manner:
$$ \mathbf{Absolute}\ \mathbf{variability} = \left(\mathbf{2}*\left(\left|\mathbf{Test}\ \hbox{--}\ \mathbf{Retest}\right|\right)\right)\ /\ \left(\mathbf{Test} + \mathbf{Retest}\right)\Big)\ *\ \mathbf{100} $$
 
Raw SUV
SUVWB
SUVC
Frontal Lobe
6.05
1.01
4.36
(2.45)
(0.67)
(4.84)
Parietal Lobe
6.69
0.97
5.15
(2.33)
(0.77)
(5.10)
Temporal Lobe
5.92
0.61
3.78
(3.13)
(0.49)
(4.92)
Occipital Lobe
6.81
1.07
3.87
(2.83)
(0.88)
(3.79)
Hippocampus
5.82
1.57
5.35
(1.95)
(1.34)
(6.50)
Parahippocam-pal cortex
5.05
2.07
5.77
(3.78)
(2.58)
(7.96)
Posterior Cingulate
6.58
1.89
5.92
(2.60)
(1.33)
(5.97)
Amygdala
3.45
4.31
6.54
(4.50)
(3.17)
(8.56)
Cerebellum
7.18
4.18
 
(7.84)
(5.07)
Whole Brain
6.09
  
(2.73)
Mean (SD)
5.96
1.96
5.09
(3.41)
(1.81)
(5.95)
These analyses allow for easier comparison with other studies however do no alter the findings or discussion of the paper – SUV normalised to whole brain (SUVWB) shows the lowest variability in our cohort, with increased variability found in the unadjusted SUV and the SUV normalised to cerebellum. As compared to other test-retest studies discussed in the paper, the variability for SUV based methods remains favourable in this pilot cohort. These results should be validated in larger studies.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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Titel
Erratum to: Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer's disease
verfasst von
Akshay Nair
Mattia Veronese
Xiaohui Xu
Charles Curtis
Federico Turkheimer
Robert Howard
Suzanne Reeves
Publikationsdatum
01.12.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
EJNMMI Research / Ausgabe 1/2017
Elektronische ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-017-0256-5

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