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Diabetologia

Erschienen in:

01.11.2012 | Article

Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals

verfasst von: D. X. Yu, Q. Sun, X. W. Ye, A. Pan, G. Zong, Y. H. Zhou, H. X. Li, F. B. Hu, X. Lin

Erschienen in: Diabetologia | Ausgabe 11/2012

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Abstract

Aims/hypothesis

Few data are available about intakes and food sources of trans-fatty acids (TFAs) or their associations with cardiometabolic outcomes in Asian people who consume a prudent diet but are experiencing rapid nutritional transitions. We aimed to investigate the relationships between TFA biomarkers and type 2 diabetes and cardiovascular risk factors in Chinese individuals.

Methods

Erythrocyte fatty acids were measured by gas chromatography among 3,107 men and women (50–70 years) recruited from urban and rural areas in Beijing and Shanghai, China.

Results

Total trans-18:1 and two trans-18:2 isomers were detected and accounted for 0.37% of the total fatty acids in the erythrocytes. Concentrations of TFAs were higher in women than men, and in urban than rural residents. Of the TFAs, trans-18:1, but not trans-18:2, showed a modest association with dairy consumption (β = 0.27), but not with other foods. After adjustment for BMI, social-demographic, lifestyle and dietary factors and other TFAs, erythrocyte trans-18:1 was shown to be associated with a lower risk of type 2 diabetes (OR comparing extreme [first and fourth] quartiles 0.68, 95% CI 0.48, 0.97, p _trend = 0.02), as well as 20–50% lower odds of central obesity, dyslipidaemia, hyperglycaemia, insulin resistance and chronic inflammation. In contrast, trans-18:2 fatty acids were positively associated with high triacylglycerol (p _trend < 0.001) and LDL-cholesterol (p _trend = 0.03) levels, but not with diabetes and other cardiometabolic risk factors.

Conclusions/interpretation

Among middle-aged and older Chinese individuals with overall low erythrocyte TFAs levels, trans-18:1 might serve as a marker of dairy intake. Higher trans-18:1 levels were associated with a lower risk of type 2 diabetes, whereas higher trans-18:2 levels were associated with dyslipidaemia.

Nur mit Berechtigung zugänglich

Hu FB, Liu Y, Willett WC (2011) Preventing chronic diseases by promoting healthy diet and lifestyle: public policy implications for China. Obes Rev 12:552–559PubMedCrossRef

Wang Y, Mi J, Shan XY, Wang QJ, Ge KY (2007) Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China. Int J Obes (Lond) 31:177–188CrossRef

Micha R, Mozaffarian D (2009) Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes. Nat Rev Endocrinol 5:335–344PubMedCrossRef

Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC (2006) Trans fatty acids and cardiovascular disease. N Engl J Med 354:1601–1613PubMedCrossRef

Mozaffarian D, Aro A, Willett WC (2009) Health effects of trans-fatty acids: experimental and observational evidence. Eur J Clin Nutr 63(Suppl 2):S5–S21PubMedCrossRef

Motard-Bélanger A, Charest A, Grenier G et al (2008) Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am J Clin Nutr 87:593–599PubMed

Chardigny JM, Destaillats F, Malpuech-Brugere C et al (2008) Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. Am J Clin Nutr 87:558–566PubMed

van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB (2002) Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 25:417–424PubMedCrossRef

Salmeron J, Hu FB, Manson JE et al (2001) Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 73:1019–1026PubMed

10.

Morio B, Tardy AL, Chardigny JM, Malpuech-Brugere C (2011) Ruminant and industrial sources of trans-fat and cardiovascular and diabetic diseases. Nutr Res Rev 24:111–117CrossRef

11.

Tholstrup T, Raff M, Basu S, Nonboe P, Sejrsen K, Straarup EM (2006) Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men. Am J Clin Nutr 83:237–243PubMed

12.

Lemaitre RN, King IB, Mozaffarian D et al (2006) Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study. Circulation 114:209–215PubMedCrossRef

13.

Mozaffarian D, Cao H, King IB et al (2010) Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann Intern Med 153:790–799PubMed

14.

Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X (2007) Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol 49:1798–1805PubMedCrossRef

15.

Yu Z, Ye X, Wang J et al (2009) Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older Chinese people. Circulation 119:2969–2977PubMedCrossRef

16.

Zhai F, Yang X (eds) (2006) The nutrition and health status of the Chinese people 2002: diet and nutrients intake. People’s Medical Publishing House, Beijing

17.

Zhao W, Hasegawa K, Chen J (2002) The use of food-frequency questionnaires for various purposes in China. Public Health Nutr 5(6A):829–833PubMedCrossRef

18.

Shi Z, Hu X, Yuan B et al (2006) Association between dietary patterns and anemia in adults from Jiangsu Province in Eastern China. Br J Nutr 96:906–912PubMedCrossRef

19.

Yang Y (ed) (2005) Chinese food composition table 2004. Peking University Medical Press, Beijing

20.

Atkinson FS, Foster-Powell K, Brand-Miller JC (2008) International tables of glycemic index and glycemic load values: 2008. Diabetes Care 31:2281–2283PubMedCrossRef

21.

American Diabetes Association (2007) Diagnosis and classification of diabetes mellitus. Diabetes Care 30(Suppl 1):S42–S47CrossRef

22.

Grundy SM, Cleeman JI, Daniels SR et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752PubMedCrossRef

23.

Pearson TA, Mensah GA, Alexander RW et al (2003) Markers of inflammation and cardiovascular diseases: application to clinical and public health practice. Circulation 107:499–511PubMedCrossRef

24.

Sun Q, Ma J, Campos H, Hankinson SE, Hu FB (2007) Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. Am J Clin Nutr 86:74–81PubMed

25.

Baylin A, Kim MK, Donovan-Palmer A et al (2005) Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: comparison with adipose tissue and plasma. Am J Epidemiol 162:373–381PubMedCrossRef

26.

Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65:1220S–1228S, discussion 1229S-1231SPubMed

27.

Sun Q, Ma J, Campos H et al (2007) A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 115:1858–1865PubMedCrossRef

28.

Micha R, King IB, Lemaitre RN et al (2010) Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study. Am J Clin Nutr 91:883–893PubMedCrossRef

29.

Sun Q, Ma J, Campos H, Hu FB (2007) Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart diseased. Am J Clin Nutr 86:929–937PubMed

30.

No authors listed (1995) Trans fatty acids and coronary heart disease risk. Report of the expert panel on trans fatty acids and coronary heart disease. Am J Clin Nutr 62: 655S-708S; discussion 518–626

31.

Beydoun MA, Gary TL, Caballero BH, Lawrence RS, Cheskin LJ, Wang Y (2008) Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome. Am J Clin Nutr 87:1914–1925PubMed

32.

Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA (2011) Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr 93:615–627PubMedCrossRef

33.

Smedman AE, Gustafsson IB, Berglund LG, Vessby BO (1999) Pentadecanoic acid in serum as a marker for intake of milk fat: relations between intake of milk fat and metabolic risk factors. Am J Clin Nutr 69:22–29PubMed

34.

Wolk A, Furuheim M, Vessby B (2001) Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. J Nutr 131:828–833PubMed

35.

Willett W (1998) Nutritional epidemiology. Oxford University Press, New YorkCrossRef

36.

Elwood PC, Pickering JE, Givens DI, Gallacher JE (2010) The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: an overview of the evidence. Lipids 45:925–939PubMedCrossRef

37.

Crichton GE, Bryan J, Buckley J, Murphy KJ (2011) Dairy consumption and metabolic syndrome: a systematic review of findings and methodological issues. Obes Rev 12:e190–e201PubMedCrossRef

38.

Villegas R, Gao YT, Dai Q et al (2009) Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women’s Health Study. Am J Clin Nutr 89:1059–1067PubMedCrossRef

39.

Wang Y, Lu J, Ruth MR et al (2008) Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp rats. J Nutr 138:2117–2122PubMedCrossRef

40.

Bassett CM, Edel AL, Patenaude AF et al (2010) Dietary vaccenic acid has antiatherogenic effects in LDLr−/− mice. J Nutr 140:18–24PubMedCrossRef

41.

Smit LA, Willett WC, Campos H (2010) Trans-fatty acid isomers in adipose tissue have divergent associations with adiposity in humans. Lipids 45:693–700PubMedCrossRef

42.

Thompson AK, Minihane AM, Williams CM (2011) Trans fatty acids and weight gain. Int J Obes (Lond) 35:315–324CrossRef

43.

Sébédio JL, Chardigny JM, Malpuech-Brugère C, Erickson MD (2006) Deep frying chemistry. Physiological effects of trans and cyclic fatty acids: Nutrition and Practical Applications. AOCS Press, Urbana, pp 205–228

Titel: Erythrocyte trans-fatty acids, type 2 diabetes and cardiovascular risk factors in middle-aged and older Chinese individuals
verfasst von: D. X. Yu
Q. Sun
X. W. Ye
A. Pan
G. Zong
Y. H. Zhou
H. X. Li
F. B. Hu
X. Lin
Publikationsdatum: 01.11.2012
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 11/2012
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-012-2674-2

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