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Breast Cancer Research

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01.10.2000 | Review

Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors

verfasst von: Marc Ruff, Monique Gangloff, Jean Marie Wurtz, Dino Moras

Erschienen in: Breast Cancer Research | Ausgabe 5/2000

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Abstract

Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crystal structures of their DNA-binding domains give some insight into how nuclear receptors discriminate between DNA response elements. The various ligand-binding domain crystal structures of the two known estrogen receptor isotypes (α and β) allow one to interpret ligand specificity and reveal the interactions responsible for stabilizing the activation helix H12 in the agonist and antagonist positions.

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Titel: Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors
verfasst von: Marc Ruff
Monique Gangloff
Jean Marie Wurtz
Dino Moras
Publikationsdatum: 01.10.2000
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2000
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr80

Springer Medizin

Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors

Abstract

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