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Erschienen in: Archives of Gynecology and Obstetrics 2/2011

01.02.2011 | Materno-fetal Medicine

Ethnic differences in age-related changes of postpartum hemoglobin levels

verfasst von: Eitan Rubin, Michal Gordon, Ruslan Sergienko, Micha Ragolsky, Eitan Lunenfeld, Eyal Sheiner

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2011

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Abstract

Objective

Postpartum hemoglobin (Hb) levels may impact maternal and breast-fed newborn well being and health. Yet, the sources of variation in maternal postpartum Hb levels are poorly understood. We set to investigate whether age has an effect on postpartum Hb levels, and if this effect is similar in different ethnic groups.

Study design

The birth records of over 200,000 births in a tertiary medical center were scanned for the first and second births to Jewish and Bedouin mothers in Israel. Age trends in Hb levels were analyzed using linear and bi-linear models. Confounding factors were eliminated by testing the significance of the preferred model in homogenous sub-populations.

Results

In Jewish Israeli mothers, postpartum hemoglobin level follow a bi-linear trend, peaking at the age of 27–31 years, both during the first and second births. In Israeli Bedouin mothers, a linear decline is observed through all ages.

Conclusion

These results suggest an ethnic difference in the age trends of postpartum Hb levels. Clinically, significant changes may occur between the ages of 27 and 30 years.
Literatur
1.
Zurück zum Zitat Levy A, Fraser D, Katz M, Mazor M, Sheiner E (2005) Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 122(2):182–186CrossRefPubMed Levy A, Fraser D, Katz M, Mazor M, Sheiner E (2005) Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 122(2):182–186CrossRefPubMed
2.
Zurück zum Zitat Bodnar LM, Cogswell ME, McDonald T (2005) Have we forgotten the significance of postpartum iron deficiency? Am J Obstet Gynecol 193(1):36–44CrossRefPubMed Bodnar LM, Cogswell ME, McDonald T (2005) Have we forgotten the significance of postpartum iron deficiency? Am J Obstet Gynecol 193(1):36–44CrossRefPubMed
3.
Zurück zum Zitat Dirren H, Logman M, Barclay DV, Freire WB (1994) Altitude correction for hemoglobin. Eur J Clin Nutr 48(9):625–632PubMed Dirren H, Logman M, Barclay DV, Freire WB (1994) Altitude correction for hemoglobin. Eur J Clin Nutr 48(9):625–632PubMed
4.
Zurück zum Zitat Pilia G, Chen W, Scuteri A, Orrú M, Albai G, Dei M et al (2006) Heritability of cardiovascular and personality traits in 6, 148 Sardinians. PLoS Genet 2(8):e132CrossRefPubMed Pilia G, Chen W, Scuteri A, Orrú M, Albai G, Dei M et al (2006) Heritability of cardiovascular and personality traits in 6, 148 Sardinians. PLoS Genet 2(8):e132CrossRefPubMed
5.
Zurück zum Zitat Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME (2006) The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol 194(2):512–519CrossRefPubMed Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME (2006) The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol 194(2):512–519CrossRefPubMed
6.
Zurück zum Zitat Earl R, Woteki CE (eds) (1993) Iron deficiency anemia: recommended guidelines for the prevention, detection, and management among U.S. Children and women of childbearing age Earl R, Woteki CE (eds) (1993) Iron deficiency anemia: recommended guidelines for the prevention, detection, and management among U.S. Children and women of childbearing age
7.
Zurück zum Zitat Petersen LA, Lindner DS, Kleiber CM, Zimmerman MB, Hinton AT, Yankowitz J (2002) Factors that predict low hematocrit levels in the postpartum patient after vaginal delivery. Am J Obstet Gynecol 186(4):737–744CrossRefPubMed Petersen LA, Lindner DS, Kleiber CM, Zimmerman MB, Hinton AT, Yankowitz J (2002) Factors that predict low hematocrit levels in the postpartum patient after vaginal delivery. Am J Obstet Gynecol 186(4):737–744CrossRefPubMed
8.
Zurück zum Zitat Scholl TO, Hediger ML (eds) (1993) Anemia and iron-deficiency anemia—compilation of data on pregnancy outcome. 1993 Symposium on recent developments in maternal nutrition and their implications for practitioners; 1993 April 30–May 02, New Harmony, IN Scholl TO, Hediger ML (eds) (1993) Anemia and iron-deficiency anemia—compilation of data on pregnancy outcome. 1993 Symposium on recent developments in maternal nutrition and their implications for practitioners; 1993 April 30–May 02, New Harmony, IN
9.
Zurück zum Zitat Weatherburn MW (1981) Laboratory normal ranges (reference values) and the clinical interpretation of laboratory results. J Clin Chem Clin Biochem 19(8):870–871 Weatherburn MW (1981) Laboratory normal ranges (reference values) and the clinical interpretation of laboratory results. J Clin Chem Clin Biochem 19(8):870–871
10.
Zurück zum Zitat Hawkins WW, Speck E, Leonard VG (1954) Variation of the hemoglobin level with age and sex. Blood 9(10):999–1007PubMed Hawkins WW, Speck E, Leonard VG (1954) Variation of the hemoglobin level with age and sex. Blood 9(10):999–1007PubMed
11.
Zurück zum Zitat Pett LB, Ogilvie GF (1948) Haemoglobin levels at different ages. Can Med Assoc J 58(4):353–355PubMed Pett LB, Ogilvie GF (1948) Haemoglobin levels at different ages. Can Med Assoc J 58(4):353–355PubMed
12.
Zurück zum Zitat Flegar-Mestrić Z, Nazor A, Jagarinec N (2000) Haematological profile in healthy urban population (8–70 years of age). Coll Antropol 24(1):185–196PubMed Flegar-Mestrić Z, Nazor A, Jagarinec N (2000) Haematological profile in healthy urban population (8–70 years of age). Coll Antropol 24(1):185–196PubMed
13.
Zurück zum Zitat Castro OL, Haddy TB, Rana SR (1987) Age-related and sex-related blood-cell values in healthy black-Americans. Public Health Rep 102(2):232–237PubMed Castro OL, Haddy TB, Rana SR (1987) Age-related and sex-related blood-cell values in healthy black-Americans. Public Health Rep 102(2):232–237PubMed
14.
Zurück zum Zitat Cruickshank JM (1970) Some variations in normal haemoglobin concentration. Br J Haematol 18(5):523–529CrossRefPubMed Cruickshank JM (1970) Some variations in normal haemoglobin concentration. Br J Haematol 18(5):523–529CrossRefPubMed
15.
Zurück zum Zitat Yip R, Johnson C, Dallman PR (1984) Age-related-changes in laboratory values used in the diagnosis of anemia and iron-deficiency. Am J Clin Nutr 39(3):427–436PubMed Yip R, Johnson C, Dallman PR (1984) Age-related-changes in laboratory values used in the diagnosis of anemia and iron-deficiency. Am J Clin Nutr 39(3):427–436PubMed
16.
Zurück zum Zitat Giorno R, Clifford JH, Beverly S, Rossing RG (1980) Hematology reference values—analysis by different statistical techniques and variations with age and sex. Am J Clin Pathol 74(6):765–770PubMed Giorno R, Clifford JH, Beverly S, Rossing RG (1980) Hematology reference values—analysis by different statistical techniques and variations with age and sex. Am J Clin Pathol 74(6):765–770PubMed
17.
Zurück zum Zitat Cembrowski GS, Fairbanks VF (1995) Can hematology reference intervals be derived from hospitalized patients data. Clin Chem 41(7):1048–1050PubMed Cembrowski GS, Fairbanks VF (1995) Can hematology reference intervals be derived from hospitalized patients data. Clin Chem 41(7):1048–1050PubMed
18.
Zurück zum Zitat Sirdah MM, Tarazi IS, Jeadi HE, Haddad RMA (2008) Normal blood cells reference intervals of healthy adults at the Gaza Strip-Palestine. J Clin Lab Anal 22(5):353–361CrossRefPubMed Sirdah MM, Tarazi IS, Jeadi HE, Haddad RMA (2008) Normal blood cells reference intervals of healthy adults at the Gaza Strip-Palestine. J Clin Lab Anal 22(5):353–361CrossRefPubMed
19.
Zurück zum Zitat Fliss A, Ragolsky M, Rubin E (2008) Reverse translational bioinformatics: a bioinformatics assay of age, gender and clinical biomarkers. AMIA summit on translation bioinformatics, San Francisco, USA Fliss A, Ragolsky M, Rubin E (2008) Reverse translational bioinformatics: a bioinformatics assay of age, gender and clinical biomarkers. AMIA summit on translation bioinformatics, San Francisco, USA
20.
Zurück zum Zitat Davies RB (2002) Hypothesis testing when a nuisance parameter is present only under the alternative: linear model case. Biometrika 89(2):484–489CrossRef Davies RB (2002) Hypothesis testing when a nuisance parameter is present only under the alternative: linear model case. Biometrika 89(2):484–489CrossRef
21.
Zurück zum Zitat Sheiner E, Shoham-Vardi I, Hershkovitz R, Katz M, Mazor M (eds) Infertility treatment is an independent risk factor for cesarean section among nulliparous women aged 40 and above. 21st Annual meeting of the society-of-maternal–fetal-medicine; 2001 February 05–10; Reno, Nevada Sheiner E, Shoham-Vardi I, Hershkovitz R, Katz M, Mazor M (eds) Infertility treatment is an independent risk factor for cesarean section among nulliparous women aged 40 and above. 21st Annual meeting of the society-of-maternal–fetal-medicine; 2001 February 05–10; Reno, Nevada
22.
Zurück zum Zitat Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA (2008) A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 23(3):699–708CrossRefPubMed Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA (2008) A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 23(3):699–708CrossRefPubMed
23.
Zurück zum Zitat Cruickshank JM, Alexander MK (1970) Effect of age, sex, parity, haemoglobin level, and oral contraceptive preparations on normal leucocyte count. Br J Haematol 18(5):541–550CrossRefPubMed Cruickshank JM, Alexander MK (1970) Effect of age, sex, parity, haemoglobin level, and oral contraceptive preparations on normal leucocyte count. Br J Haematol 18(5):541–550CrossRefPubMed
24.
Zurück zum Zitat Karmon A, Levy A, Holcberg G, Wiznitzer A, Mazor M, Sheiner E (2009) Decreased perinatal mortality among women with diet-controlled gestational diabetes mellitus. Int J Gynaecol Obstet 104(3):199–202CrossRefPubMed Karmon A, Levy A, Holcberg G, Wiznitzer A, Mazor M, Sheiner E (2009) Decreased perinatal mortality among women with diet-controlled gestational diabetes mellitus. Int J Gynaecol Obstet 104(3):199–202CrossRefPubMed
25.
Zurück zum Zitat Dickstein Y, Ohel I, Levy A, Holcberg G, Sheiner E (2008) Lack of prenatal care: an independent risk factor for perinatal mortality among macrosomic newborns. Arch Gynecol Obstet 277(6):511–514CrossRefPubMed Dickstein Y, Ohel I, Levy A, Holcberg G, Sheiner E (2008) Lack of prenatal care: an independent risk factor for perinatal mortality among macrosomic newborns. Arch Gynecol Obstet 277(6):511–514CrossRefPubMed
26.
Zurück zum Zitat Sheiner E, Hallak M, Twizer I, Mazor M, Katz M, Shoham-Vardi I (2001) Lack of prenatal care in two different societies living in the same region and sharing the same medical facilities. J Obstet Gynaecol 21(5):453–458CrossRefPubMed Sheiner E, Hallak M, Twizer I, Mazor M, Katz M, Shoham-Vardi I (2001) Lack of prenatal care in two different societies living in the same region and sharing the same medical facilities. J Obstet Gynaecol 21(5):453–458CrossRefPubMed
Metadaten
Titel
Ethnic differences in age-related changes of postpartum hemoglobin levels
verfasst von
Eitan Rubin
Michal Gordon
Ruslan Sergienko
Micha Ragolsky
Eitan Lunenfeld
Eyal Sheiner
Publikationsdatum
01.02.2011
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 2/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-009-1306-7

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