Background
Methods
Study design, setting and population
Selection of haemoglobin meters
Data collection and Haemoglobin measurement
Definition of terms
Population | No anaemia | Mild | Anaemia | Severe |
---|---|---|---|---|
Moderate | ||||
Children 6-59 months of age | 110 or higher | 100–109 | 70–99 | Lower than 70 |
Children 4–11 years of age | 115 or higher | 110–114 | 80–109 | Lower than 80 |
Children 12–14 years of age | 120 or higher | 110–119 | 80–109 | Lower than 80 |
Non-pregnant woman (15 years of age and above) | 120 or higher | 110–119 | 80–109 | Lower than 80 |
Pregnant women | 110 or higher | 100–109 | 70–99 | Lower than 70 |
Men (15 years of age and above) | 130 or higher | 110–129 | 80–109 | Lower than 80 |
Units of haemoglobin in g/l
Statistical analysis
Results
Characteristics | Overall | Women | Men |
---|---|---|---|
N(%) | 228 (100%) | 124 (54.4%) | 104 (45.6%) |
Age, years | |||
Mean (SD) | 42.4 (17.3) | 43.3 (17.0) | 41.0 (17.6) |
Median | 40 | 39 | 40.5 |
25th–75th percentile | 31–55 | 31.5–57.5 | 30.5–53.5 |
Min-Max | 4–85 | 9–82 | 4–85 |
Age ranges, years | |||
4–11 | 08 (3.51%) | 1 (0.44%) | 7 (3.07%) |
12–14 | 04 (1.75) | 4 (1.75%) | 4 (1.75%) |
15–85 | 216 (94.74%) | 119 (52.19%) | 93 (40.79%) |
Pregnancy | 08 (3.51%) | 08 (6.45%) | NA |
Technical accuracy
Clinical accuracy
Haemoglobin meter | Subgroup | Measurement | Mean | SD | % difference | Statistical significance | TE% | Mean*TE% | Allowable range | Clinical significance | |
---|---|---|---|---|---|---|---|---|---|---|---|
Min | Max | ||||||||||
MissionHb® | Overall | Reference | 10.5 | 2.5 | 0 | < 0.001 | 4.19 | 0.4 | 10.1 | 10.9 | Significant |
MissionHb | 11.6 | 2.5 | 10.5 | ||||||||
Women | Reference | 10.2 | 2.1 | 0 | < 0.001 | 4.19 | 0.4 | 9.8 | 10.6 | Significant | |
MissionHb | 11.2 | 2.2 | 9.8 | ||||||||
Men | Reference | 10.9 | 2.8 | 0 | < 0.001 | 4.19 | 0.5 | 10.4 | 11.4 | Significant | |
MissionHb | 12 | 2.8 | 10 | ||||||||
Urit12® | Overall | Reference | 10.5 | 2.5 | 0 | < 0.001 | 4.19 | 0.4 | 10.1 | 10.9 | Non-significant |
Urit12 | 10.9 | 2.7 | 3.8 | ||||||||
Women | Reference | 10.2 | 2.1 | 0 | < 0.001 | 4.19 | 0.4 | 9.8 | 10.6 | Non-significant | |
Urit12 | 10.5 | 2.4 | 2.9 | ||||||||
Men | Reference | 10.9 | 2.8 | 0 | < 0.001 | 4.19 | 0.5 | 10.4 | 11.4 | Non-significant | |
Urit12 | 11.4 | 3 | 4.6 |
Agreement with the reference analyser in diagnosing the presence and severity of anemia
Meters | Area under curve (AUC) [95% CI] |
---|---|
Reference Analyser | 0.9776 [09624–0.9929] |
MissionHb® | 0.9161 [0.8764–0.95586] |
Urit 12® | 0.9009 [0.8601–0.9416] |
Reference analyser | MissionHb® | ||||
---|---|---|---|---|---|
No anaemia | Mild anaemia | Moderate anaemia | Severe anaemia | Total | |
No anaemia | 54 | 2 | 1 | 0 | 57 |
Mild anaemia | 38 | 20 | 4 | 0 | 62 |
Moderate anaemia | 12 | 27 | 29 | 0 | 68 |
Severe anaemia | 0 | 0 | 19 | 22 | 41 |
Total | 104 | 49 | 53 | 22 | 228 |
Reference analyser | Urit12® | ||||
---|---|---|---|---|---|
No anaemia | Mild anaemia | Moderate anaemia | Severe anaemia | Total | |
No anaemia | 48 | 6 | 3 | 0 | 57 |
Mild anaemia | 24 | 25 | 13 | 0 | 62 |
Moderate anaemia | 6 | 15 | 45 | 2 | 68 |
Severe anaemia | 0 | 0 | 8 | 33 | 41 |
Total | 78 | 46 | 69 | 35 | 228 |