Erschienen in:
01.06.2005 | Poster Presentation
Ex vivo isolation of adult stem cells from normal and tumour mouse mammary parenchyma
verfasst von:
G Bonizzi, A Cicalese, B Giulini, S Pesce, A Gobbi, S Pece, PP Di Fiore, PG Pelicci
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
It is generally believed that tumours originate from adult tissues, in which most cells are quiescent, and that the proliferative advantage of tumour cells arises from their ability to bypass senescence. Once this is obtained, cells can accumulate further genetic alterations that drive progressive transformation into highly malignant derivatives. How normal cells evade the senescence program remains an unresolved issue. …