Introduction
Methods
Parameter median (range) | Whole tested group (N = 72) | Women (N = 34) | Men (N = 38) |
---|---|---|---|
Age | 64.00 (36.00–86.0) | 63.00 (36.00–78.00) | 64.50 (38.00–86.00) |
HGB (g/dL) | 13.10 (5.90–18.10) | 13.20 (5.90–16.60) | 12.85 (8.00–18.10) |
WBC (G/L) | 57.75 (6.90–628.00) | 53.20 (6.90–149.00) | 58.25 (9.70–628.00) |
LIMF (G/L) | 51.55 (5.70–540.00) | 43.15 (5.70–131.80) | 52.65 (6.01–540.00) |
PLT (G/L) | 173.00 (47.00–341.00) | 202.50 (84.00–341.00) | 155.50 (47.00–325.00) |
B2 M (mg/L) | 3.31 (0.80–4434.50) | 3.19 (1.86–4421.90) | 3.56 (0.80–4434.50) |
LDH (U/L) | 351.00 (108.00–1732.00) | 356.00 (108.00–997.00) | 327.50 (151.00–1732.00) |
CD38 (%) | 13.37 (0.15–82.36) | 20.13 (0.15–54.00) | 25.51 (0.54–82.36) |
ZAP70 (%) | 18.45 (1.51–69.74) | 21.74 (1.51–68.58) | 23.77 (2.17–69.14) |
TTM | 10.40 (2.40–25.20) | 8.60 (2.40–12.40) | 11.35 (2.80–25.20) |
Cytogenetic analyses
FISH
Statistical analyses
Results
Clonal changes detected using classical cytogenetics technique
Item | Karyotype during diagnosis (baseline) | FISH during diagnosis (baseline) | FISH, 2nd testing (follow-up) | Karyotype, 2nd testing (follow-up) |
---|---|---|---|---|
1 | 46,XY[21] | 13q- | 13q-,6q- | 46,XY,del(13)(q14q21)[6]/46,sl,del(6)(q24)[3]/ 46,XY[14] |
2 | 47,XY, +12[11]/46,XY[16] | +12 | +12 | 47,XY, +12 [14]/46,XY[8] |
3 | 46,XX[20] | 13q- | 13q-,17p- | 46,XX,del(13)(q14q21)[8]/46,XX[12] |
4 | 46,XY,t(9;14)(p12;q32)[8]/46,XY[12] | 13q- | 13q-,17p- | 45,XY,t(9;14)(p12;q32),-13,-16, +mar[6]/46,XY[15] |
5 | 46,XY, del(13)(q14)[4]/46,XY[24] | 13q-,17p- | 13q-,17p- | 45,XY,del(13)(q14),-20[8]/46,XY[12] |
6 | 46,XX[30] | 13q- | 13q-,17p- | 46,XX[20] |
7 | 46,XX[26] | 13q biallel | 13q biallel | 46,XX,del(13)(q14)[11]/46,XX[9] |
8 | 46,XY[19] | 13q- | 13q- | 46,XY[24] |
9 | 46,XY,del(13)(q14q21)[6]/46,XY[12] | 13q-,17p- | 13q-,17p- | 46,XY,del(13)(q14q21)[3]/46,XY,del(13)(q14q21), del(17)(p12)[4]/46,XY[16] |
10 | 46,XY[22] | 13q-,11q- | 13q-,11q- | 46,XY,del(13)(q14)[7]/46,sl,del(11)(q22q23)[4]/ 46,XY[8] |
11 | 46,XX[27] | N | N | 46,XX[23] |
12 | 46,XX[23] | 13q-,11q- | 13q-,11q- | 46,XX,del(13)(q12q14)[5]/46,XX[26] |
13 | 46,XX[24] | 13q-,11q- | 13q-,11q- | 46,XX,del(13)(q12q22)[6]/46,XX[11] |
14 | 46,XX[21] | 13q-, +12 | 13q-, +12 | 47,XX, +12[4]/46,XX[16] |
15 | 46,XY[28] | 13q-,11q- | 13q-,17p- | 46,XY[24] |
16 | 46,XY[27] | 11q- | 11q- | 46,XY[24] |
17 | 46,XX,del(13)(q12)[3]/46,XX[20] | 13q- | 13q- | 46,XX,del (13)(q12)[6],46,XX[12] |
18 | 46,XY[21] | 13q- | 13q- | 46,XY[20] |
19 | 46,XY[26] | 17p- | 6q-,17p- | 46,XY[24] |
20 | 46,XY[19] | 13q- | 13q- | 46,XY,del(13)(q14)[6]/46,XY[14] |
21 | 46,XX,del(13)(q14)[7]/46,XX[13] | 13q- | 13q-,17p- | 46,XX,del(13)(q14)[8]/46,sl,del(17)(p12)[5]/46,XX [9] |
22 | 46,XY[22] | 13q- | 13q- | 46,XY[27] |
23 | 46,XX,del(13)(q14)[4]/46,XX[15] | 13q- | 13q- | 46,XX,del(13)(q14)[10]/46,XX[13] |
24 | 46,XX,del(13)(q12q34)[3]/46,XX[15] | 13q-,11q- | 13q- | 45,X,-X,del(13)(q12q34)[5]/46,XX[16] |
25 | 46,XY,del(13)(q14)[8]/46,XY[12] | 13q- | 13q- | 46,XY,t(6;13)(q15;q14)[2]/46,XY,del(13)(q14)[4]/ 46,XY[12] |
26 | 47,XY, +12[3]/46,XY[19] | +12 | +12 | 47,XY, +12[4]/46,XY[16] |
27 | 46,XX,del(13)(q14q21)[5]/46,XX[14] | 13q-, +12 | 13q-, +12 | 47,XX, +12,del(13)(q14q21)[cp6]/46,XX[13] |
28 | 46,XY[25] | 13q-,17p- | 13q-,17p- | 46,XY[24] |
29 | 46,XX[21] | 13q- | 13q- | 46,XX[23] |
30 | 46,XY[27] | 13q- | 13q biallelic | 46,XY[25] |
31 | 46,XX[22] | 13q- | 13q- | 46,XX[20] |
32 | 46,XX,del(13)(q14)[8]/46,XX[24] | 13q- | 13q- | 46,XX,del(13)(q14)[4]/46,XX[18] |
33 | 46,XX,del(13)(q14)[4]/46,XX[16] | 13q- | 13q- | 47,XX,del(13)(q14), +mar[6]/46,XX[14] |
34 | 46,XY[20] | N | N | 46,XY[26] |
35 | 46,XY[24] | 11q- | 11q- | 47 ~ 48,XY, +1~2mar[16] |
36 | 44 ~ 46,XX,-6,-17, +1~2mar[cp16] | 6q- | 6q-,17p- | 44 ~ 46,XX,del(6)(q15),-17, +1~3mar[cp14] |
37 | 46,XX[25] | 13q- | 13q biallelic | 46,XX[26] |
38 | 46,XY,del(14)(q12)[3]/46,XY[22] | 13q-,17p- | 13q-,17p- | 46,XY,del(14)(q12),der(17)del(17)(p13)del(17)(q21)[5]/ 46,XY[14] |
39 | 43,XY,-13,der(15;15)(q10;q10),-17[5]/46,XY[10] | 13q-,17p- | 13q-,17p- | 43,XY,-13,der(15;15)(q10;q10),-17[6]/46,XY[14] |
40 | 45 ~ 46,XY,del(6)(q21),de(l13)(q14),-18[cp9]/46,XY[7] | 13q-,6q- | 13q-,6q- | 45 ~ 47,XY,del(6)(q21),del(13)(q14),-18, +mar [cp5]/ 46,XY[16] |
41 | 45,XX,t(6;11)(p25;q23),-12[4]/46,XX[15] | 6q- | 6q- | 46,XX,t(6;11)(p25;q23)[3]/46,XX[16] |
42 | 46,XX,add(13)(q34)[3]/46,XX[20] | N | add13 | 46,XX,add(13)(q34)[9]/46,XX[12] |
43 | 47,XX, +21[4]/46,XX[27] | N | N | 47,XX, +21[5]/46,XX,der(3)t(3;13)(p21;q14)[5]/ 46,XX[17] |
44 | 46,XY[30] | N | N | 46,XY,t(18;22)(q21;q11)[6]/46,XY[24] |
45 | 46,XY[20] | 13q- | 13q- | 46,XY,der(13)del(13)(q14)t(10;13)(p14;q21)[5]/ 46,XY[25] |
46 | 46,XY[12] | 13q- | 13q- | 46,XY,del(13)(q14),add(12)(p13)[4]/46,XY[12] |
47 | 46 ~ 48,XX,t(1;12)(q31;q24),t(6;11)(p25;q23), +12, +18[cp8] | +12 | +12 | 46,XX,t(1;12)(q31;q24), +12[6]/46,sl,add(3)(q24)[3] |
48 | 46,XX[17] | 11q | 11q-,17p- | 49,XX, +8,del(11)(q22), +19, +21[cp12] |
49 | 45,XX,del(2)(q32q36),-10,-22, +mar[cp12] | 6q- | 6q- | 46,XX,del(6)(q21)[3]/46,XX,del(2)(q32q36),-10, +mar[8] |
50 | 46,XY,t(6;13)(q25;q14)[3]/46,XY[14] | 13q- | 13q- | 46,XY,t(6;13)(q25;q14)[6]/46,sl,del(11)(q13), -16, +mar[9] |
51 | 46,XY,t(2;4)(q21;p14)[3]/46,XY[16] | 13q- | 13q- | 46,XY,t(2;4)(q21;p14)[4]/46,sl,del (13)(q14q22)[3]/ 46,XY[10] |
52 | 46,XY,del(11)(q14)[5]/46,XY[12] | 11q-,13q- | 11q-,13q- | 46,XY,del(11)(q14)[7]/46,XY[13] |
53 | 46,XX,del(13)(q12q22)[6]/46,XX[12] | 13q- | 13q biallelic | 46,XX,del(13)(q12q22)[7]/46,XX[14] |
54 | 46,XY,t(7;13)(q36;q13),del(11)(q14)[4]/46,XY,del(11)(q14)[2]/46,XY[8] | 11q-,13q- | 11q-,13q- | 46,XY,t(7;13)(q36;q13),del(11)(q14)[6]/45,XY, del(11)(q14),-14[3]/46,XY[9] |
55 | 45 ~ 46,X,-X,del(8)(q22),-13, +mar[cp6]/46,XX[23] | 13q-,17p- | 13q-,17p- | 44 ~ 45,X,-X,del(8)(q22),-13 [cp7]/46,XX[18] |
56 | 44 ~ 45,XY,del(8)(p23.3p22),-11,del(13)(q14),-15[cp11]/46,XY[5] | 13q-,17p-, +12 | 13q biallelic,17p, +12 | 44 ~ 46,XY,del(8)(p23.3p22),-11,del(13)(q14), del(14)(q24), -15,-17, +mar[cp8]/46,XY[11] |
57 | 46,XY,del(13)(q14)[3]/46,XY[23] | 13q-,11q-,17p- | 13q- biallelic,11q-,17p- | 46,XY,del(13)(q14)[7]/46,XY[19] |
58 | 46,XY[24] | 13q- | 13q- | 46,XY[23] |
59 | 44,XX,del(1)(q41),del(8)(q24.1), del(9)(q22), der(10)t(10;11) (p15;q14),del(11)(q14), add(14)(q23), der(15;15)(q10;q10), -21[cp6]/ 46,XX[7] | 13q-,17p- | 13q-,17p- | 46,XX,del(8)(q24.1)[9]/45,XX,del(1)(q41), del(8)(q24.1),del(9)(q22),der(10) t(10;11) (p15;q14),del(11)(q14),add(14)(q23),der(15;15)(q10;q10),-17,-21, +2mar[cp9]/46,XX[5] |
60 | 46,XY,del(11)(q22q23)[7]/46,sl,t(11;14) (q21;q23)[4]/46,XY[9] | 13q-,11q- | 13q-,11q- | 46,XY,del(11)(q22q23),t(11;14)(q21;q23)[6]/46,XY[12] |
61 | 47,XY, +12[7]/46,XY[12] | +12 | +12 | 47,XY, + 12[5]/46,XY[14] |
62 | 46,XX[23] | +12 | +12 | 46,XX[26] |
63 | 46,XY[19] | 17p- | 17p- | 46,XY,del(17)(p12)[4]/46,XY[16] |
64 | 46,XY,t(3;9)(q13;q34)[7]/45,XY, t(3;9)(q13;q34),21[3]/46,XY[12] | 13q-, +12 | 13q-, +12 | 44 ~ 45,XY,t(3;9)(q13;q34),-13,-21[cp8]/46,XY[16] |
65 | 46,XX[21] | 13q-, 11q- | 13q-,11q- | 46,XX[25] |
66 | 46,XX[19] | 11q- | 11q- | 44 ~ 46,XX,-8,-22, +mar[cp4]/46,XX[12] |
67 | 46,XX,t(1;2)(q23;q36)[5]/46,XX[14] | 13q-, 11q- | 13q-,11q- | 46,XX,t(1;2)(q23;q36)[3]/46,XX,del(5)(q13q31)[2]/ 46,XX[12] |
68 | 46,XY,t(2;22)(p21;p11)[5]/45,XY,der(10) t(10;19)(p14;q13),del(11)(p14),-21[4]/46,XY[8] | +12 | +12 | 46,XY,t(2;22)(p21;p11)[3]/47,XY, +12[4]/46,XY[9] |
69 | 46,XY,t(9;10)(q12;q25),-13[4]/46,XY,del(12)(q23)[3]/46,XY[23] | 13q-, 11q- | 13q-, 11q- | 46,XY,t(9;10)(q12;q25)[7]/46,XY,del(12)(q23)[5]/46,XY,t(2;3)(p25;p14)[3]/45,XY,-13[3]/46,XY[14] |
70 | 45,XX,del(2)(q22),-14[6]/ 46,XX,del(9)(q21)[3]/46,XX[20] | +12 | +12 | 45,XX,del(2)(q22),-14[3]/46,XX[22] |
71 | 46,XX,t(11;12)(q14;p13)[5]/46,XX,t(1;16)(p33;p13)[4]/49,XX, +12, +18, 21[3]/46,XX[15] | +12 | +12 | 46,XX,t(11;12)(q14;p13), +18[5]/48,XX,t(9;16) (p10;q10), +12, +18[4]/46,XX[20] |
72 | 46,XX[22] | 13q-, 11q- | 13q-, 11q- | 46,XX,t(4;13)(q28,q34)[5]/46,XX[23] |
Clonal changes detected using the FISH technique
Genetic markers | CBA I (N) | CBA II (N) | FISH I (N) | FISH II (N) |
---|---|---|---|---|
del 17p and del TP53 monosomy 17 | 2 | 9 | 11 | 17 |
del 11q | 5 | 8 | 17 | 15 |
Trisomy 12 | 5 | 8 | 12 | 12 |
del 13q | 14 | 29 | 50 | 50 |
del 6q | 2 | 4 | 4 | 6 |
Complex karyotype | 9 | 15 | – | – |