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ADHD Attention Deficit and Hyperactivity Disorders

Erschienen in:

01.03.2010 | Original Article

Exercise impact on sustained attention of ADHD children, methylphenidate effects

verfasst von: José A. Medina, Turibio L. B. Netto, Mauro Muszkat, Afonso C. Medina, Denise Botter, Rogério Orbetelli, Luzia F. C. Scaramuzza, Elaine G. Sinnes, Márcio Vilela, Mônica C. Miranda

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 1/2010

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Abstract

Attention deficit hyperactivity disorder (ADHD) is related to a deficiency of central catecholamines (CA) in cognitive, biochemical, and physical tests, and pharmaceutical intervention may have no effect if it is not accompanied by changes in the environment. The objective of our study was to test the hypothesis that central CA are responsible for the increase in speed reaction seen after physical activity (PA) and to measure the impact of high intensity PA on the sustained attention of 25 children diagnosed with ADHD consistent with the Disease Statistical Mental-IV (DSM-IV) criteria. It is possible that practicing sports assists in the management of the disorder. The children were divided between users (US) and non-users (NUS) of methylphenidate (MTP), and the groups were compared to evaluate the effect of the drug on cognition after PA. Post-exercise performance on Conner’s Continuous Performance Test-II (CPT) was not affected by MTP, we observed significant improvements in response time, and we saw normalization in the impulsivity and vigilance measures. These results suggest that the improvements in cognition after physical effort are not CA dependent. Additionally, our results suggest that children’s attention deficits can be minimized through PA irrespective of treatment with MTP. Additional studies are necessary to confirm that exercise mitigates the harmful symptoms of ADHD.

Acheson A, Conover JC, Fandl JP et al (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374(6521):450–453CrossRefPubMed

Anderson GM, Dover MA, Yang BP et al (2000) Adrenomedullary function during cognitive testing in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 39:635–643CrossRefPubMed

Baillard JE, Boileau RA, Sleator EK et al (1976) Cardiovascular responses of hyperactive children to methylphenidate. JAMA 236(25):2870–2874CrossRef

Bekinschtein P, Cammarota M, Katche C et al (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci USA 105(7):2711–2716CrossRefPubMed

Berridge CW, Devilbiss DM, Andrzejewski ME et al (2006) Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biol Psychiatry 60(10):1111–1120CrossRefPubMed

Boileau RA, Ballard JE, Sprague RL et al (1976) Effect of methylphenidate on cardio respiratory responses in hyperactive children. Res Q 47:590–596PubMed

Brisswalter J, Collardeau M, René A (2002) Effects of acute physical exercise characteristics on cognitive performance. Sports Med 32:555–566CrossRefPubMed

Chen C, Burton M, Greenberger E et al (1999) Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe. Evol Hum Behav 20(5):309–324CrossRef

Conners CK (1969) A teacher rating scale for use in drug studies with children. Am J Psychiatry 126(6):884–888PubMed

Conners CK, Staff MHS (2000) Continuous performance test II (CPT-II) computer programs for windows tecnical guide. Multi-Health Systems, Noth Tonawada

Cotman CW, Berchtold NC (2002) Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci 25:295–301CrossRefPubMed

Craft DH (1983) Effect of prior exercise on cognitive performance tasks by hyperactive and normal young boys. Percept Mot Skills 56(3):979–982PubMed

Eisenberg DT, MacKillop J, Modi M et al (2007) Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav Brain Func 3:2CrossRef

Eisenberg DT, Campbell B, Gray PB et al (2008) Dopamine receptor genetic polymorphisms and body composition in undernourished pastoralists: an exploration of nutrition indices among nomadic and recently settled ariaal men of northern Kenya. BMC Evol Biol 8:173CrossRefPubMed

Farrel PA, Wilmore JH, Coyle EF et al (1979) Plasma lactate accumulation and distance running performance. Med Sci Sports 11:338–344

Freed CR, Yamamoto BK (1985) Regional brain dopamine metabolism: a marker for the speed, direction and posture of moving animals. Science 229:62–65CrossRefPubMed

Girardi NL, Shaywitz SE, Shaywitz BA et al (1995) Blunted catecholamine responses after glucose ingestion in children with attention deficit disorder. Pediatr Res 38:539–542CrossRefPubMed

Goldman LS, Genel M, Bezman RJ et al (1998) Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. JAMA 279(14):1100–1107CrossRefPubMed

Hattori S, Naoi M, Nishino H (1994) Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running. Brain Res Bull 35:41–49CrossRefPubMed

Hattori S, Hashitani T, Matsui N et al (1996) Dynamic regulation of striatal dopaminergic grafts during locomotor activity. Brain Res 710:45–55CrossRefPubMed

Hendren RL, De Backer I, Pandina GJ (2000) Review of neuroimaging studies of child and adolescent psychiatric disorders from the past 10 years. J Am Acad Child Adolesc Psychiatry 39:815–828CrossRefPubMed

Hochhaus L (1972) A table for the calculation of d and p. Psychol Bull 77(5):375–376CrossRef

Jensen PS, Arnold LE, Swanson JM et al (2007) 3-year follow-up of the NIMH MTA study. J Am Acad Child Adolesc Psychiatry 46(8):989–1002CrossRefPubMed

Kim JJ, Diamond DM (2002) The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci 3(6):453–462CrossRefPubMed

Kimko HC, Cross JT, Abernethy DR (1999) Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet 37(6):457–470CrossRefPubMed

Klein SA, Deffenbacher JL (1977) Relaxation and exercise for hyperactive impulsive children. Percept Mot Skills 45(3 Pt 2):1159–1162PubMed

Koehl M, Meerlo P, Gonzales D et al (2008) Exercise-induced promotion of hipocampal cell proliferation requires beta-endorphin. FASEB J 22(7):2253–2262CrossRefPubMed

Kuczenski R, Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. J Neurochem 68(5):2032–2037PubMedCrossRef

Li D, Sham PC, Owen MJ et al (2006) Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 15(14):2276–2284CrossRefPubMed

Losier BJ, McGrath PJ, Klein RM (1996) Error patterns on the continuous performance test in non-medicated and medicated samples of children with and without ADHD: a meta-analytic review. J Child Psychol Psychiatry 37(8):971–987CrossRefPubMed

MacRae PG, Spirduso WW, Cartee GD et al (1987) Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolite levels. Neurosci Lett 79:138–144CrossRefPubMed

Mahon AD, Stephens BR, Cole AS (2008) Exercise responses in boys with attention deficit/hyperactivity disorder: effects of stimulant medication. J Atten Disord 12:170–176CrossRefPubMed

Mannelli M, Lazzeri C, Ianni L et al (1997) Dopamine and sympathoadrenal activity in man. Clin Exp Hypertens 19(1–2):163–179CrossRefPubMed

Marcondes E, Berquó ES, Yunes J et al (1969) Estudo antropométrico de crianças brasileiras de zero a doze anos de idade. Anais Nestlé, São Paulo

McMorris T, Collard K, Corbett J et al (2008) A test of the catecholamines hypothesis for an acute exercise-cognition interaction. Pharmacol Biochem Behav 89(1):106–115CrossRefPubMed

Meeusen R, Smolders I, Sarre S et al (1997) Endurance training effects on neurotransmitter release in rat striatum–an in vivo microdialysis study. Acta Physiol Scand 159:335–341CrossRefPubMed

Miranda H, Simão R, Lemos A et al (2005) Análise da freqüência cardíaca, pressão arterial e duplo-produto em diferentes posições corporais nos exercícios resistidos. Rev Bras Med Esporte 11:295–298CrossRef

Nair J, Ehimare U, Beitman BD et al (2006) Clinical review: evidence-based diagnosis and treatment of ADHD in children. Mo Med 103(6):617–621PubMed

Nybo L, Nielsen B, Blomstrand E et al (2003) Neurohumoral responses during prolonged exercise in humans. J Appl Physiol 95:1125–1131PubMed

Quay HC (1997) Inhibition and attention deficit hyperactivity disorder. J Abnorm Child Psychol 25(1):7–13CrossRefPubMed

Reybrouck T, Weymans M, Stijns H (1985) Ventilatory anaerobic threshold in healthy children age and sex differences. Eur J Appl Physiol Occup Physiol 54(3):278–284CrossRefPubMed

Rösler M, Retz W, Retz-Junginger P et al (2004) Prevalence of attention deficit-/hyperactivity disorder (ADHD) and comorbid disorders in young male prison inmates. Eur Arch Psychiatry Clin Neurosci 254(6):365–371CrossRefPubMed

Schwarz L, Kindermann W (1990) b-Endorfina, adrenocorticotropic, cortisol and catecholamines during aerobic and anaerobic exercise. Eur J Appl Physiol 61:165–171CrossRef

Souza I, Serra MA, Mattos P et al (2001) Comorbidity in children and adolescents with attention-deficit disorder: preliminary results. Arq Neuropsiquiatr 59:401–406PubMed

Spencer T, Biederman J, Wilens T (2000) Pharmacotherapy of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 9(1):77–97PubMed

Strong WB, Malina RM, Blimkie CJR et al (2005) Evidence based physical activity for school-age youth. J Pediatr 146:732–737CrossRefPubMed

Swanson J, Gupta S, Guinta D et al (1999) Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children. Clin Pharmacol Ther 66(3):295–305CrossRefPubMed

Tanaka H, Seals DR (2008) Endurance exercise performance in masters athletes: age-associated changes and underlying physiological mechanisms. J Physiol 586(1):55–63CrossRefPubMed

Tanner JM (1962) Growth at adolescence, 2nd edn. Blackwell Scientific Publications, Oxford

Tanner JM, Davies PS (1985) Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 107(3):317–329CrossRefPubMed

Tantillo M, Kesick CM, Hynd GW et al (2002) The effects of exercise on children with attention-deficit hyperactivity disorder. Med Sci Sports Exerc 34(2):203–212CrossRefPubMed

Tella SR, Goldberg SR (1998) Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav 59(2):305–312CrossRefPubMed

Tomporowski PD (2003) Effects of acute bouts of exercise on cognition. Acta Psychol (Amst) 112:297–324CrossRef

Van Craenenbroeck K, Clark SD, Cox MJ et al (2005) Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J Biol Chem 280(19):9350–9357

van den Buuse M (1998) Role of the mesolimbic dopamine system in cardiovascular homeostasis. Stimulation of the ventral tegmental area modulates the effect of vasopressin on blood pressure in conscious rats. Clin Exp Pharmacol Physiol 25(9):661–668CrossRefPubMed

Volkow ND, Wang GJ, Fowler SJ et al (2003) Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma. Psychopharmacology (Berl) 166:264–270

Wang GJ, Volkow ND, Fowler JS et al (2000) PET studies of the effects of aerobic exercise on human striatal dopamine release. J Nucl Med 41(8):1352–1356PubMed

Wang E, Ding YC, Flodman P et al (2004) The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 74(5):931–934CrossRefPubMed

Wasserman K, McLlory MB (1964) Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. Am J Cardiol 14:844–852CrossRefPubMed

Weiss G, Kruger E, Danielson U (1975) Effect of long-term treatment of hyperactive children with methylphenidate. Can Med Assoc J 112(2):159–165PubMed

Werry JS, Aman MG (1975) Methylphenidate and haloperidol in children. Effects on attention, memory, and activity. Arch Gen Psychiatry 32(6):790–795PubMed

Wigal S, Nemet D, Swanson JM et al (2003) Catecholamine response to exercise in children with attention deficit hyperactivity. Pediatr Res 53(5):756–761CrossRefPubMed

Winter B, Breitenstein C, Mooren FC et al (2007) High impact running improves learning. Neurobiol Learn Mem 87:597–609CrossRefPubMed

Yamada K, Nabeshima T (2003) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci 91(4):267–270CrossRefPubMed

Titel: Exercise impact on sustained attention of ADHD children, methylphenidate effects
verfasst von: José A. Medina
Turibio L. B. Netto
Mauro Muszkat
Afonso C. Medina
Denise Botter
Rogério Orbetelli
Luzia F. C. Scaramuzza
Elaine G. Sinnes
Márcio Vilela
Mônica C. Miranda
Publikationsdatum: 01.03.2010
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 1/2010
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-009-0018-y

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