Background
Methods
Study setting, design, and population
Zone | State |
---|---|
North Central | Kwara (9 110), Niger (31 817) |
North East | Adamawa (49 084), Bauchi (29 670), Borno (21 989), Yobe (8 239) |
North West | Jigawa (12 190), Kano (52 205), Kebbi (8 318), Sokoto (6 624) |
South-South | Akwa Ibom (223 922), Bayelsa (13 971), Cross River (79 436), Edo (33 250) |
South West | Lagos (73 495) |
Data source and management
Computed variables explored as predictors of IIT
Statistical analysis
Results
Cohort characteristics
Factors | Treatment interruptions | |||
---|---|---|---|---|
No (%) | Yes (%) | Total (%) | p-value | |
Sex | ||||
Female | 258 926 (68) | 119 540 (32) | 378 466 (66) | <0.000001 |
Male | 131 658 (67) | 63 506 (33) | 195 164 (34) | |
Age group at ART start | ||||
0–14 | 18 059 (64) | 10 126 (36) | 28 185 (5) | <0.000001 |
15–24 | 66 479 (65) | 35 543 (35) | 102 022 (18) | |
25–34 | 152 473 (68) | 71 631 (32) | 224 104 (39) | |
35–44 | 100 090 (70) | 42 068 (30) | 142 158 (25) | |
45–59 | 48 021 (70) | 20 715 (30) | 68 736 (12) | |
60+ | 5 462 (65) | 2 963 (35) | 8 425 (1) | |
Age group | ||||
0–14 | 13 900 (60) | 9 080 (40) | 22 980 (4) | <0.000001 |
15–24 | 38 231 (60) | 25 956 (40) | 64 187 (11) | |
25–34 | 120 558 (65) | 65 931 (35) | 186 489 (33) | |
35–44 | 123 625 (71) | 49 653 (29) | 173 278 (30) | |
45–59 | 79 890 (74) | 27 592 (26) | 107 482 (19) | |
60+ | 14 380 (75) | 4 834 (25) | 19 214 (3) | |
Zone | ||||
South-South | 217 601 (71) | 87 480 (29) | 305 081 (53) | <0.000001 |
North Central | 32 701 (86) | 5 211 (14) | 37 912 (7) | |
North East | 58 339 (64) | 33 131 (36) | 91 470 (16) | |
North West | 49 162 (65) | 26 342 (35) | 75 504 (13) | |
South West | 32 781 (51) | 30 882 (49) | 63 663 (11) | |
Facility level | ||||
Primary | 125 158 (86) | 20 347 (14) | 145 505 (25) | <0.000001 |
Secondary | 213 505 (63) | 126 249 (37) | 339 754 (59) | |
Tertiary | 51 921 (59) | 36 450 (41) | 88 371 (15) | |
Regimen line | ||||
Adult 1st Line | 369 290 (68) | 173 205 (32) | 542 495 (95) | <0.000001 |
Adult 2nd Line | 9 770 (75) | 3 198 (25) | 12 968 (2) | |
Adult 3rd Line | 11 (100) | 0 (0) | 11 (0) | |
Peds 1st Line | 10 985 (63) | 6 512 (37) | 17 497 (3) | |
Peds 2nd Line | 509 (80) | 128 (20) | 637 (0) | |
Salvage | 19 (86) | 3 (14) | 22 (0) | |
MMD | ||||
1 | 11 842 (12) | 90 756 (88) | 102 598 (18) | <0.000001 |
2 | 15 395 (18) | 68 913 (82) | 84 308 (15) | |
3-5 | 199 678 (90) | 21 098 (10) | 220 776 (38) | |
6 | 163 669 (99) | 2 279 (1) | 165 948 (29) | |
VL | ||||
0 – Suppressed | 272 968 (94) | 18 237 (6) | 291 205 (51) | <0.000001 |
Not recorded | 90 281 (37) | 156 449 (63) | 246 730 (43) | |
Unsuppressed | 27 335 (77) | 8 360 (23) | 35 695 (6) |
Factors associated with treatment interruption
Factors | Univariate | Multivariate | ||
---|---|---|---|---|
OR [95% CI] | p (<0.000001) | OR [95% CI] | p (<0.000001) | |
Sex | ||||
Female | 1 [ref] | 0 | 1 [ref] | 0 |
Male | 1.04 [1.03 - 1.06] | <0.000001 | 0.91 [0.89 - 0.93] | <0.000001 |
Age group | ||||
0-14 | 1 [ref] | <0.000001 | 1 [ref] | 0 |
15-24 | 1.04 [1.01 - 1.07] | 0.014073 | 1.08 [0.97 - 1.19] | 0.16165 |
25-34 | 0.84 [0.81 - 0.86] | <0.000001 | 1.19 [1.08 - 1.32] | 0.000539 |
35-44 | 0.61 [0.6 - 0.63] | <0.000001 | 1.13 [1.02 - 1.25] | 0.0185935 |
45-59 | 0.53 [0.51 - 0.54] | <0.000001 | 1.08 [0.97 - 1.19] | 0.147981 |
60+ | 0.51 [0.49 - 0.54] | <0.000001 | 1.22 [1.08 - 1.36] | 0.000822 |
Zone | ||||
South-South | 1 [ref] | 0 | 1 [ref] | 0 |
North Central | 0.4 [0.38 - 0.41] | <0.000001 | 0.4 [0.38 - 0.42] | <0.000001 |
North East | 1.41 [1.39 - 1.43] | <0.000001 | 1.36 [1.32 - 1.4] | <0.000001 |
North West | 1.33 [1.31 - 1.36] | <0.000001 | 0.83 [0.8 - 0.85] | <0.000001 |
South West | 2.34 [2.3 - 2.38] | <0.000001 | 1.99 [1.92 – 2.06] | 0 |
Facility level | ||||
Primary level | 1 [ref] | 0 | 1 [ref] | 0 |
Secondary level | 3.64 [3.58 - 3.7] | <0.000001 | 4.01 [3.9 - 4.13] | <0.000001 |
Tertiary level | 4.32 [4.23 - 4.41] | <0.000001 | 12.34 [11.87 - 12.82] | <0.000001 |
Regimen line | ||||
Adult first line | 1 [ref] | 0 | 1 [ref] | 0 |
Adult.2nd.Line | 0.7 [0.67 - 0.73] | <0.000001 | 0.09 [0.09 - 0.1] | 0 |
Adult.3rd.Line | 0 [0 - 5.91e+14] | 0.686815 | 0 [0 – 4.45e+20] | 0.702157 |
Peds.1st.Line | 1.26 [1.23 - 1.3] | <0.000001 | 0.35 [0.32 - 0.39] | <0.000001 |
Peds.2nd.Line | 0.54 [0.44 - 0.65] | <0.000001 | 0.08 [0.06 - 0.1] | <0.000001 |
Salvage | 0.34 [0.1 - 1.14] | 0.079702 | 0.02 [0 - 0.06] | <0.000001 |
MMD | ||||
1 | 1 [ref] | 0 | 1 [ref] | 0 |
2 | 0.7 [0.67 - 0.73] | <0.000001 | 0.78 [0.76 - 0.81] | <0.000001 |
3-5 | 0.1 [0.09 - 0.1] | <0.000001 | 0.02 [0.02 - 0.02] | <0.000001 |
6 | 0.04 [0.03 - 0.04] | <0.000001 | 0.01 [0 - 0.01] | <0.000001 |
VL | ||||
Suppressed | 1 [ref] | 0 | 1 [ref] | 0 |
Not recorded | 7.1 [6.89 - 7.32] | <0.000001 | 10.02 [9.76 – 10.28] | <0.000001 |
Unsuppressed | 1.99 [1.9 - 2.09] | <0.000001 | 2.23 [2.14 - 2.33] | <0.000001 |