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Environmental Health and Preventive Medicine

Erschienen in:

01.05.2008 | Regular Article

Factors associated with serum total homocysteine level in type 2 diabetes

verfasst von: Yumi Masuda, Akira Kubo, Akatsuki Kokaze, Masao Yoshida, Nobuki Fukuhara, Yutaka Takashima

Erschienen in: Environmental Health and Preventive Medicine | Ausgabe 3/2008

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Abstract

Objectives

The aim of this study was to investigate the determinants of serum total homocysteine level (tHcy) in patients with type 2 diabetes mellitus (DM) according to sex.

Methods

A total of 1,276 Japanese, diabetics (n = 280) with a control group of non-diabetics (n = 996), were enrolled into the study from 2003 to 2005. This cross-sectional study was conducted for all the subjects, using personal data regarding clinical characteristics and lifestyle. Multiple regression analysis was performed to analyze the association of tHcy with selected factors.

Results

In diabetic subjects, estimated glomerular filtration rate (eGFR) and serum creatinine levels (Cre), even those within the normal range, were strongly associated with tHcy after adjustment in both sexes; the standardized partial regression coefficient of eGFR for tHcy was −0.251, (p = 0.001) in diabetic men and −0.523, (p < 0.001) in diabetic women. Furthermore, the eGFR of the diabetics, except patients with nephropathy, also had significant association with tHcy in both sexes. Fasting plasma glucose levels and serum triglyceride levels were strongly associated with tHcy in diabetic men only. HbA1c was also associated with tHcy in diabetic men only, though not as significantly. Age and presence of hypertension were significantly associated with tHcy in women.

Conclusions

This study suggests that there are some differences in the factors associated with tHcy between diabetics and non-diabetics, and between the sexes. There is, therefore, circumstantial evidence that elevated tHcy should be evaluated clinically. Because tHcy was strongly associated with eGFR and Cre, even within the normal ranges, tHcy may have important implications regarding the microangiopathy of the kidney and atherosclerosis.

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Titel: Factors associated with serum total homocysteine level in type 2 diabetes
verfasst von: Yumi Masuda
Akira Kubo
Akatsuki Kokaze
Masao Yoshida
Nobuki Fukuhara
Yutaka Takashima
Publikationsdatum: 01.05.2008
Verlag: Springer Japan
Erschienen in: Environmental Health and Preventive Medicine / Ausgabe 3/2008
Print ISSN: 1342-078X
Elektronische ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-008-0024-2

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Factors associated with serum total homocysteine level in type 2 diabetes

Abstract

Objectives

Methods

Results

Conclusions

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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