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01.09.2009 | Review Article

Fixed-Dose Combinations as Initial Therapy for Hypertension

A Review of Approved Agents and a Guide to Patient Selection

verfasst von: Prof. Bernard Waeber, François Feihl, Luis M. Ruilope

Erschienen in: Drugs | Ausgabe 13/2009

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Abstract

Recent guidelines recommend initiation of antihypertensive therapy with fixed-dose combinations in high-risk patients because such patients usually need two or more blood pressure (BP)-lowering agents in order to normalize their BP. Agents that block the renin-angiotensin system (ACE inhibitors or angiotensin II receptor antagonists [angiotensin receptor blockers; ARBs]) are preferred for the management of hypertension in most patients exhibiting subclinical target organ damage, or established cardiovascular or renal diseases. Unless contraindicated they should be one of the components of fixed-dose combinations, whereas the other component may be either a calcium channel antagonist or a thiazide diuretic. Fixed-dose combinations containing an ACE inhibitor or ARB plus a calcium channel antagonist appear particularly effective in preventing complications of coronary heart disease.

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Titel: Fixed-Dose Combinations as Initial Therapy for Hypertension
A Review of Approved Agents and a Guide to Patient Selection
verfasst von: Prof. Bernard Waeber
François Feihl
Luis M. Ruilope
Publikationsdatum: 01.09.2009
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 13/2009
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/11316710-000000000-00000

Springer Medizin

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