Erschienen in:
01.10.2015 | From Bench to Bedside
From Bench to Bedside: Alpha-defensin—The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?
verfasst von:
Benjamin K. Potter, MD
Erschienen in:
Clinical Orthopaedics and Related Research®
|
Ausgabe 10/2015
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Excerpt
We have been awaiting the arrival of 21
st century biomarker-, gene- or sequence-driven personalized medicine since well before the millennium. Yet the “Golden Age” of personalized medicine has proven elusive. While total joint arthroplasty (TJA) alleviates suffering perhaps better than any other orthopaedic intervention [
8], patients whose arthroplasties have been complicated by infection have a very different experience. The condition is painful, the treatments are inconsistent, and most vexingly, our approaches to diagnosing the condition fall well short of what our patients expect from us in the second decade of the 21
st century. …