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Erschienen in: Current Infectious Disease Reports 5/2012

01.10.2012 | Skin, Soft Tissue, Bone and Joint Infections (N Safdar, Section Editor)

From Ulcer to Infection: An Update on Clinical Practice and Adjunctive Treatments of Diabetic Foot Ulcers

verfasst von: C. Abad, N. Safdar

Erschienen in: Current Infectious Disease Reports | Ausgabe 5/2012

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Abstract

Foot ulcers are a common complication of diabetes. A fifth of all individuals with diabetes develop a diabetic foot infection and are hospitalized at least once in their lifetime. Standard of care for treatment of diabetic foot ulcers and subsequent infection involves a multimodal, interdisciplinary team approach that includes wound care, systemic antimicrobials, and surgery. However, with the relatively poor outcome for chronic, longstanding ulcers and severe infections, recent research has focused on adjunctive therapies to promote wound healing and repair. This review summarizes the underlying pathology and classification of diabetic ulcers and focuses on recent advances that have important implications for the use of adjunctive therapy for diabetic foot infections.
Literatur
1.
Zurück zum Zitat Boulton AJ. The diabetic foot: a global view. Diabetes Metab Res Rev. 2000;16 Suppl 1:S2–5.PubMedCrossRef Boulton AJ. The diabetic foot: a global view. Diabetes Metab Res Rev. 2000;16 Suppl 1:S2–5.PubMedCrossRef
2.
3.
Zurück zum Zitat Lipsky BA, Peters EJ, Senneville E, et al. Expert opinion on the management of infections in the diabetic foot. Diabetes Metab Res Rev. 2012;28 Suppl 1:163–78.PubMedCrossRef Lipsky BA, Peters EJ, Senneville E, et al. Expert opinion on the management of infections in the diabetic foot. Diabetes Metab Res Rev. 2012;28 Suppl 1:163–78.PubMedCrossRef
4.
Zurück zum Zitat Pecoraro RE, Ahroni JH, Boyko EJ, Stensel VL. Chronology and determinants of tissue repair in diabetic lower-extremity ulcers. Diabetes. 1991;40:1305–13.PubMedCrossRef Pecoraro RE, Ahroni JH, Boyko EJ, Stensel VL. Chronology and determinants of tissue repair in diabetic lower-extremity ulcers. Diabetes. 1991;40:1305–13.PubMedCrossRef
5.
Zurück zum Zitat Reiber GE, Pecoraro RE, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus. A case-control study. Ann Intern Med. 1992;117:97–105.PubMed Reiber GE, Pecoraro RE, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus. A case-control study. Ann Intern Med. 1992;117:97–105.PubMed
6.
Zurück zum Zitat Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care. 1999;22:157–62.PubMedCrossRef Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care. 1999;22:157–62.PubMedCrossRef
7.
Zurück zum Zitat Kumar S, Ashe HA, Parnell LN, et al. The prevalence of foot ulceration and its correlates in type 2 diabetic patients: a population-based study. Diabet Med. 1994;11:480–4.PubMedCrossRef Kumar S, Ashe HA, Parnell LN, et al. The prevalence of foot ulceration and its correlates in type 2 diabetic patients: a population-based study. Diabet Med. 1994;11:480–4.PubMedCrossRef
8.
Zurück zum Zitat Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993;36:150–4.PubMedCrossRef Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993;36:150–4.PubMedCrossRef
9.
Zurück zum Zitat Young MJ, Breddy JL, Veves A, Boulton AJ. The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds. A prospective study. Diabetes Care. 1994;17:557–60.PubMedCrossRef Young MJ, Breddy JL, Veves A, Boulton AJ. The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds. A prospective study. Diabetes Care. 1994;17:557–60.PubMedCrossRef
10.
Zurück zum Zitat Young MJ, Jones GC. Diabetic neuropathy: symptoms, signs and assessment. In: Boulton AJM, editor. Diabetic neuropathy. Lancashire: Marius Press; 1997. p. 41–61. Young MJ, Jones GC. Diabetic neuropathy: symptoms, signs and assessment. In: Boulton AJM, editor. Diabetic neuropathy. Lancashire: Marius Press; 1997. p. 41–61.
11.
Zurück zum Zitat Masson EA, Hay EM, Stockley I, Veves A, Betts RP, Boulton AJ. Abnormal foot pressures alone may not cause ulceration. Diabet Med. 1989;6:426–8.PubMedCrossRef Masson EA, Hay EM, Stockley I, Veves A, Betts RP, Boulton AJ. Abnormal foot pressures alone may not cause ulceration. Diabet Med. 1989;6:426–8.PubMedCrossRef
12.
Zurück zum Zitat Veves A, Murray HJ, Young MJ, Boulton AJ. The risk of foot ulceration in diabetic patients with high foot pressure: a prospective study. Diabetologia. 1992;35:660–3.PubMedCrossRef Veves A, Murray HJ, Young MJ, Boulton AJ. The risk of foot ulceration in diabetic patients with high foot pressure: a prospective study. Diabetologia. 1992;35:660–3.PubMedCrossRef
13.
Zurück zum Zitat Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990;13:513–21.PubMedCrossRef Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care. 1990;13:513–21.PubMedCrossRef
14.
Zurück zum Zitat Frykberg RG, Zgonis T, Armstrong DG, et al. Diabetic foot disorders. A clinical practice guideline (2006 revision). J Foot Ankle Surg. 2006;45:S1–S66.PubMedCrossRef Frykberg RG, Zgonis T, Armstrong DG, et al. Diabetic foot disorders. A clinical practice guideline (2006 revision). J Foot Ankle Surg. 2006;45:S1–S66.PubMedCrossRef
15.
Zurück zum Zitat Rothman KJ. Causes. Am J Epidemiol. 1976;141:90–5. 1995; discussion 89. Rothman KJ. Causes. Am J Epidemiol. 1976;141:90–5. 1995; discussion 89.
16.
Zurück zum Zitat Powlson AS, Coll AP. The treatment of diabetic foot infections. J Antimicrob Chemother;65 Suppl 3:iii3–9. Powlson AS, Coll AP. The treatment of diabetic foot infections. J Antimicrob Chemother;65 Suppl 3:iii3–9.
17.
Zurück zum Zitat Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care. 1999;22:1354–60.CrossRef Consensus Development Conference on Diabetic Foot Wound Care: 7-8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care. 1999;22:1354–60.CrossRef
18.
Zurück zum Zitat Frykberg RG, Armstrong DG, Giurini J, et al. Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons. J Foot Ankle Surg. 2000;39:S1–S60.PubMedCrossRef Frykberg RG, Armstrong DG, Giurini J, et al. Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons. J Foot Ankle Surg. 2000;39:S1–S60.PubMedCrossRef
19.
Zurück zum Zitat Wagner FW. Supplement: algorithms of foot care. In: Levin ME, O’Neal LW, editors. The diabetic foot st. Louis: Mosby; 1983. p. 291–302. Wagner FW. Supplement: algorithms of foot care. In: Levin ME, O’Neal LW, editors. The diabetic foot st. Louis: Mosby; 1983. p. 291–302.
20.
Zurück zum Zitat Armstrong DG, Lavery LA, Harkless LB. Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation. Diabetes Care. 1998;21:855–9.PubMedCrossRef Armstrong DG, Lavery LA, Harkless LB. Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation. Diabetes Care. 1998;21:855–9.PubMedCrossRef
21.
Zurück zum Zitat Frykberg RG. Diabetic foot ulcers: pathogenesis and management. Am Fam Physician. 2002;66:1655–62.PubMed Frykberg RG. Diabetic foot ulcers: pathogenesis and management. Am Fam Physician. 2002;66:1655–62.PubMed
22.
Zurück zum Zitat Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diabetes Care. 2001;24:84–8.PubMedCrossRef Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diabetes Care. 2001;24:84–8.PubMedCrossRef
23.
Zurück zum Zitat Terashi H, Kitano I, Tsuji Y. Total management of diabetic foot ulcerations--Kobe classification as a new classification of diabetic foot wounds. Keio J Med. 60:17–21. Terashi H, Kitano I, Tsuji Y. Total management of diabetic foot ulcerations--Kobe classification as a new classification of diabetic foot wounds. Keio J Med. 60:17–21.
24.
Zurück zum Zitat • Lipsky BA, Berendt AR, Deery HG, et al. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2004;39:885–910. This is a comprehensive review of diagnostic and therapeutic interventions for diabetic foot ulcers. PubMedCrossRef • Lipsky BA, Berendt AR, Deery HG, et al. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2004;39:885–910. This is a comprehensive review of diagnostic and therapeutic interventions for diabetic foot ulcers. PubMedCrossRef
25.
Zurück zum Zitat Gardner SE, Hillis SL, Frantz RA. Clinical signs of infection in diabetic foot ulcers with high microbial load. Biol Res Nurs. 2009;11:119–28.PubMedCrossRef Gardner SE, Hillis SL, Frantz RA. Clinical signs of infection in diabetic foot ulcers with high microbial load. Biol Res Nurs. 2009;11:119–28.PubMedCrossRef
26.
Zurück zum Zitat Citron DM, Goldstein EJ, Merriam CV, Lipsky BA, Abramson MA. Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents. J Clin Microbiol. 2007;45:2819–28.PubMedCrossRef Citron DM, Goldstein EJ, Merriam CV, Lipsky BA, Abramson MA. Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents. J Clin Microbiol. 2007;45:2819–28.PubMedCrossRef
27.
Zurück zum Zitat El-Tahawy AT. Bacteriology of diabetic foot. Saudi Med J. 2000;21:344–7.PubMed El-Tahawy AT. Bacteriology of diabetic foot. Saudi Med J. 2000;21:344–7.PubMed
28.
Zurück zum Zitat Goldstein EJ, Citron DM, Nesbit CA. Diabetic foot infections. Bacteriology and activity of 10 oral antimicrobial agents against bacteria isolated from consecutive cases. Diabetes Care. 1996;19:638–41.PubMedCrossRef Goldstein EJ, Citron DM, Nesbit CA. Diabetic foot infections. Bacteriology and activity of 10 oral antimicrobial agents against bacteria isolated from consecutive cases. Diabetes Care. 1996;19:638–41.PubMedCrossRef
29.
Zurück zum Zitat Grayson ML. Diabetic foot infections. Antimicrobial therapy. Infect Dis Clin North Am. 1995;9:143–61.PubMed Grayson ML. Diabetic foot infections. Antimicrobial therapy. Infect Dis Clin North Am. 1995;9:143–61.PubMed
30.
Zurück zum Zitat Jones EW, Edwards R, Finch R, Jeffcoate WJ. A microbiological study of diabetic foot lesions. Diabet Med. 1985;2:213–5.PubMedCrossRef Jones EW, Edwards R, Finch R, Jeffcoate WJ. A microbiological study of diabetic foot lesions. Diabet Med. 1985;2:213–5.PubMedCrossRef
31.
Zurück zum Zitat Joseph WS, Axler DA. Microbiology and antimicrobial therapy of diabetic foot infections. Clin Podiatr Med Surg. 1990;7:467–81.PubMed Joseph WS, Axler DA. Microbiology and antimicrobial therapy of diabetic foot infections. Clin Podiatr Med Surg. 1990;7:467–81.PubMed
32.
Zurück zum Zitat Lipsky BA, Pecoraro RE, Wheat LJ. The diabetic foot. Soft tissue and bone infection. Infect Dis Clin North Am. 1990;4:409–32.PubMed Lipsky BA, Pecoraro RE, Wheat LJ. The diabetic foot. Soft tissue and bone infection. Infect Dis Clin North Am. 1990;4:409–32.PubMed
33.
Zurück zum Zitat Sims D, Keating SE, DeVincentis AF. Bacteriology of diabetic foot ulcers. J Foot Surg. 1984;23:149–51.PubMed Sims D, Keating SE, DeVincentis AF. Bacteriology of diabetic foot ulcers. J Foot Surg. 1984;23:149–51.PubMed
34.
Zurück zum Zitat Urbancic-Rovan V, Gubina M. Bacteria in superficial diabetic foot ulcers. Diabet Med. 2000;17:814–5.PubMedCrossRef Urbancic-Rovan V, Gubina M. Bacteria in superficial diabetic foot ulcers. Diabet Med. 2000;17:814–5.PubMedCrossRef
35.
Zurück zum Zitat Gerding DN. Foot infections in diabetic patients: the role of anaerobes. Clin Infect Dis. 1995;20 Suppl 2:S283–8.PubMedCrossRef Gerding DN. Foot infections in diabetic patients: the role of anaerobes. Clin Infect Dis. 1995;20 Suppl 2:S283–8.PubMedCrossRef
36.
Zurück zum Zitat Hunt JA. Foot infections in diabetes are rarely due to a single microorganism. Diabet Med. 1992;9:749–52.PubMedCrossRef Hunt JA. Foot infections in diabetes are rarely due to a single microorganism. Diabet Med. 1992;9:749–52.PubMedCrossRef
37.
Zurück zum Zitat Pathare NA, Bal A, Talvalkar GV, Antani DU. Diabetic foot infections: a study of microorganisms associated with the different Wagner grades. Indian J Pathol Microbiol. 1998;41:437–41.PubMed Pathare NA, Bal A, Talvalkar GV, Antani DU. Diabetic foot infections: a study of microorganisms associated with the different Wagner grades. Indian J Pathol Microbiol. 1998;41:437–41.PubMed
38.
Zurück zum Zitat Sapico FL, Witte JL, Canawati HN, Montgomerie JZ, Bessman AN. The infected foot of the diabetic patient: quantitative microbiology and analysis of clinical features. Rev Infect Dis. 1984;6 Suppl 1:S171–6.PubMedCrossRef Sapico FL, Witte JL, Canawati HN, Montgomerie JZ, Bessman AN. The infected foot of the diabetic patient: quantitative microbiology and analysis of clinical features. Rev Infect Dis. 1984;6 Suppl 1:S171–6.PubMedCrossRef
39.
Zurück zum Zitat Wheat LJ, Allen SD, Henry M, et al. Diabetic foot infections. Bacteriologic analysis. Arch Intern Med. 1986;146:1935–40.PubMedCrossRef Wheat LJ, Allen SD, Henry M, et al. Diabetic foot infections. Bacteriologic analysis. Arch Intern Med. 1986;146:1935–40.PubMedCrossRef
40.
Zurück zum Zitat Armstrong DG, Liswood PJ, Todd WF. William J. Stickel Bronze Award. Prevalence of mixed infections in the diabetic pedal wound. A retrospective review of 112 infections. J Am Podiatr Med Assoc. 1995;85:533–7.PubMed Armstrong DG, Liswood PJ, Todd WF. William J. Stickel Bronze Award. Prevalence of mixed infections in the diabetic pedal wound. A retrospective review of 112 infections. J Am Podiatr Med Assoc. 1995;85:533–7.PubMed
41.
Zurück zum Zitat Candel Gonzalez FJ, Alramadan M, Matesanz M, et al. Infections in diabetic foot ulcers. Eur J Intern Med. 2003;14:341–3.PubMedCrossRef Candel Gonzalez FJ, Alramadan M, Matesanz M, et al. Infections in diabetic foot ulcers. Eur J Intern Med. 2003;14:341–3.PubMedCrossRef
42.
Zurück zum Zitat Diaz Colodrero G, Altclas J, Jasovich A, Mikaelian G, Fiks G, Caro E. Microbiology and conservative surgery of serious infections of the diabetic foot. Enferm Infecc Microbiol Clin. 1992;10:451–5.PubMed Diaz Colodrero G, Altclas J, Jasovich A, Mikaelian G, Fiks G, Caro E. Microbiology and conservative surgery of serious infections of the diabetic foot. Enferm Infecc Microbiol Clin. 1992;10:451–5.PubMed
43.
Zurück zum Zitat Ge Y, MacDonald D, Hait H, Lipsky B, Zasloff M, Holroyd K. Microbiological profile of infected diabetic foot ulcers. Diabet Med. 2002;19:1032–4.PubMedCrossRef Ge Y, MacDonald D, Hait H, Lipsky B, Zasloff M, Holroyd K. Microbiological profile of infected diabetic foot ulcers. Diabet Med. 2002;19:1032–4.PubMedCrossRef
44.
Zurück zum Zitat Senneville E, Melliez H, Beltrand E, et al. Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures. Clin Infect Dis. 2006;42:57–62.PubMedCrossRef Senneville E, Melliez H, Beltrand E, et al. Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures. Clin Infect Dis. 2006;42:57–62.PubMedCrossRef
45.
Zurück zum Zitat Abdulrazak A, Bitar ZI, Al-Shamali AA, Mobasher LA. Bacteriological study of diabetic foot infections. J Diabetes Complications. 2005;19:138–41.PubMedCrossRef Abdulrazak A, Bitar ZI, Al-Shamali AA, Mobasher LA. Bacteriological study of diabetic foot infections. J Diabetes Complications. 2005;19:138–41.PubMedCrossRef
46.
Zurück zum Zitat al-Arouj M, al-Nakhi A, Baraka A, Juma T, Johny M. Foot infections in diabetics: the antibiotic choice. Can J Surg. 1993;36:170–2.PubMed al-Arouj M, al-Nakhi A, Baraka A, Juma T, Johny M. Foot infections in diabetics: the antibiotic choice. Can J Surg. 1993;36:170–2.PubMed
47.
Zurück zum Zitat Zeillemaker AM, Veldkamp KE, van Kraaij MG, Hoekstra JB, Hoynck van Papendrecht AA, Diepersloot RJ. Piperacillin/tazobactam therapy for diabetic foot infection. Foot Ankle Int. 1998;19:169–72.PubMed Zeillemaker AM, Veldkamp KE, van Kraaij MG, Hoekstra JB, Hoynck van Papendrecht AA, Diepersloot RJ. Piperacillin/tazobactam therapy for diabetic foot infection. Foot Ankle Int. 1998;19:169–72.PubMed
48.
Zurück zum Zitat O'Reilly D, Linden R, Fedorko L, et al. A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol. Trials 12:69. O'Reilly D, Linden R, Fedorko L, et al. A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol. Trials 12:69.
49.
Zurück zum Zitat Crouzet J, Lavigne JP, Richard JL and Sotto A. Diabetic foot infection: a critical review of recent randomized clinical trials on antibiotic therapy. Int J Infect Dis;15:e601–10. Crouzet J, Lavigne JP, Richard JL and Sotto A. Diabetic foot infection: a critical review of recent randomized clinical trials on antibiotic therapy. Int J Infect Dis;15:e601–10.
50.
Zurück zum Zitat Clay PG, Graham MR, Lindsey CC, Lamp KC, Freeman C, Glaros A. Clinical efficacy, tolerability, and cost savings associated with the use of open-label metronidazole plus ceftriaxone once daily compared with ticarcillin/clavulanate every 6 hours as empiric treatment for diabetic lower-extremity infections in older males. Am J Geriatr Pharmacother. 2004;2:181–9.PubMedCrossRef Clay PG, Graham MR, Lindsey CC, Lamp KC, Freeman C, Glaros A. Clinical efficacy, tolerability, and cost savings associated with the use of open-label metronidazole plus ceftriaxone once daily compared with ticarcillin/clavulanate every 6 hours as empiric treatment for diabetic lower-extremity infections in older males. Am J Geriatr Pharmacother. 2004;2:181–9.PubMedCrossRef
51.
Zurück zum Zitat Giordano P, Song J, Pertel P, Herrington J, Kowalsky S. Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infection. Int J Antimicrob Agents. 2005;26:357–65.PubMedCrossRef Giordano P, Song J, Pertel P, Herrington J, Kowalsky S. Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infection. Int J Antimicrob Agents. 2005;26:357–65.PubMedCrossRef
52.
Zurück zum Zitat Graham DR, Lucasti C, Malafaia O, et al. Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clin Infect Dis. 2002;34:1460–8.PubMedCrossRef Graham DR, Lucasti C, Malafaia O, et al. Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study. Clin Infect Dis. 2002;34:1460–8.PubMedCrossRef
53.
Zurück zum Zitat Graham DR, Talan DA, Nichols RL, et al. Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. Clin Infect Dis. 2002;35:381–9.PubMedCrossRef Graham DR, Talan DA, Nichols RL, et al. Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. Clin Infect Dis. 2002;35:381–9.PubMedCrossRef
54.
Zurück zum Zitat Harkless L, Boghossian J, Pollak R, et al. An open-label, randomized study comparing efficacy and safety of intravenous piperacillin/tazobactam and ampicillin/sulbactam for infected diabetic foot ulcers. Surg Infect (Larchmt). 2005;6:27–40.CrossRef Harkless L, Boghossian J, Pollak R, et al. An open-label, randomized study comparing efficacy and safety of intravenous piperacillin/tazobactam and ampicillin/sulbactam for infected diabetic foot ulcers. Surg Infect (Larchmt). 2005;6:27–40.CrossRef
55.
Zurück zum Zitat • Lipsky BA, Armstrong DG, Citron DM, Tice AD, Morgenstern DE, Abramson MA. Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial. Lancet. 2005;366:1695–703. This randomized controlled trial used rigorous definitions for infection in diabetic foot ulcers and found that ertapenem was noninferior to piperacillin-tazobactam as parenteral treatment for diabetic foot ulcers. PubMedCrossRef • Lipsky BA, Armstrong DG, Citron DM, Tice AD, Morgenstern DE, Abramson MA. Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial. Lancet. 2005;366:1695–703. This randomized controlled trial used rigorous definitions for infection in diabetic foot ulcers and found that ertapenem was noninferior to piperacillin-tazobactam as parenteral treatment for diabetic foot ulcers. PubMedCrossRef
56.
Zurück zum Zitat Lipsky BA, Giordano P, Choudhri S, Song J. Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. J Antimicrob Chemother. 2007;60:370–6.PubMedCrossRef Lipsky BA, Giordano P, Choudhri S, Song J. Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam/amoxicillin-clavulanate. J Antimicrob Chemother. 2007;60:370–6.PubMedCrossRef
57.
Zurück zum Zitat Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis. 2008;47:1537–45.PubMedCrossRef Lipsky BA, Holroyd KJ, Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis. 2008;47:1537–45.PubMedCrossRef
58.
Zurück zum Zitat Lipsky BA, Itani K, Norden C. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. Clin Infect Dis. 2004;38:17–24.PubMedCrossRef Lipsky BA, Itani K, Norden C. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. Clin Infect Dis. 2004;38:17–24.PubMedCrossRef
59.
Zurück zum Zitat Lipsky BA, Stoutenburgh U. Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. J Antimicrob Chemother. 2005;55:240–5.PubMedCrossRef Lipsky BA, Stoutenburgh U. Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. J Antimicrob Chemother. 2005;55:240–5.PubMedCrossRef
60.
Zurück zum Zitat Noel GJ, Bush K, Bagchi P, Ianus J, Strauss RS. A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin Infect Dis. 2008;46:647–55.PubMedCrossRef Noel GJ, Bush K, Bagchi P, Ianus J, Strauss RS. A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections. Clin Infect Dis. 2008;46:647–55.PubMedCrossRef
61.
Zurück zum Zitat Saltoglu N, Dalkiran A, Tetiker T, et al. Piperacillin/tazobactam versus imipenem/cilastatin for severe diabetic foot infections: a prospective, randomized clinical trial in a university hospital. Clin Microbiol Infect. 16:1252–7. Saltoglu N, Dalkiran A, Tetiker T, et al. Piperacillin/tazobactam versus imipenem/cilastatin for severe diabetic foot infections: a prospective, randomized clinical trial in a university hospital. Clin Microbiol Infect. 16:1252–7.
62.
Zurück zum Zitat Siami G, Christou N, Eiseman I, Tack KJ. Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections. Antimicrob Agents Chemother. 2001;45:525–31.PubMedCrossRef Siami G, Christou N, Eiseman I, Tack KJ. Clinafloxacin versus piperacillin-tazobactam in treatment of patients with severe skin and soft tissue infections. Antimicrob Agents Chemother. 2001;45:525–31.PubMedCrossRef
63.
Zurück zum Zitat Stevens DL. Teicoplanin for skin and soft tissue infections: an open study and a randomized, comparative trial versus cefazolin. J Infect Chemother. 1999;5:40–5.PubMedCrossRef Stevens DL. Teicoplanin for skin and soft tissue infections: an open study and a randomized, comparative trial versus cefazolin. J Infect Chemother. 1999;5:40–5.PubMedCrossRef
64.
Zurück zum Zitat Nelson S, Heyder AM, Stone J, et al. A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J Infect Dis. 2000;182:970–3.PubMedCrossRef Nelson S, Heyder AM, Stone J, et al. A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J Infect Dis. 2000;182:970–3.PubMedCrossRef
65.
Zurück zum Zitat Sato N, Shimizu H. Granulocyte-colony stimulating factor improves an impaired bactericidal function in neutrophils from STZ-induced diabetic rats. Diabetes. 1993;42:470–3.PubMedCrossRef Sato N, Shimizu H. Granulocyte-colony stimulating factor improves an impaired bactericidal function in neutrophils from STZ-induced diabetic rats. Diabetes. 1993;42:470–3.PubMedCrossRef
66.
Zurück zum Zitat Dale DC, Liles WC, Summer WR, Nelson S. Review: granulocyte colony-stimulating factor–role and relationships in infectious diseases. J Infect Dis. 1995;172:1061–75.PubMedCrossRef Dale DC, Liles WC, Summer WR, Nelson S. Review: granulocyte colony-stimulating factor–role and relationships in infectious diseases. J Infect Dis. 1995;172:1061–75.PubMedCrossRef
67.
Zurück zum Zitat Hartung T. Granulocyte colony-stimulating factor: its potential role in infectious disease. AIDS. 1999;13 Suppl 2:S3–9.PubMed Hartung T. Granulocyte colony-stimulating factor: its potential role in infectious disease. AIDS. 1999;13 Suppl 2:S3–9.PubMed
68.
Zurück zum Zitat Peck KR, Son DW, Song JH, Kim S, Oh MD, Choe KW. Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro. J Korean Med Sci. 2001;16:39–44.PubMed Peck KR, Son DW, Song JH, Kim S, Oh MD, Choe KW. Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro. J Korean Med Sci. 2001;16:39–44.PubMed
69.
Zurück zum Zitat Cruciani M, Lipsky BA, Mengoli C and de Lalla F. Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections. Cochrane Database Syst Rev 2009;CD006810. Cruciani M, Lipsky BA, Mengoli C and de Lalla F. Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections. Cochrane Database Syst Rev 2009;CD006810.
70.
Zurück zum Zitat de Lalla F, Pellizzer G, Strazzabosco M, et al. Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection. Antimicrob Agents Chemother. 2001;45:1094–8.PubMedCrossRef de Lalla F, Pellizzer G, Strazzabosco M, et al. Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection. Antimicrob Agents Chemother. 2001;45:1094–8.PubMedCrossRef
71.
Zurück zum Zitat Gough A, Clapperton M, Rolando N, Foster AV, Philpott-Howard J, Edmonds ME. Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet. 1997;350:855–9.PubMedCrossRef Gough A, Clapperton M, Rolando N, Foster AV, Philpott-Howard J, Edmonds ME. Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet. 1997;350:855–9.PubMedCrossRef
72.
Zurück zum Zitat Viswanathan V, Mahesh U, Jayaraman M, Shina K, Ramachandram A. Beneficial role of granulocyte colony stimulating factor in foot infection in diabetic patients. J Assoc Physicians India. 2003;51:90–1.PubMed Viswanathan V, Mahesh U, Jayaraman M, Shina K, Ramachandram A. Beneficial role of granulocyte colony stimulating factor in foot infection in diabetic patients. J Assoc Physicians India. 2003;51:90–1.PubMed
73.
Zurück zum Zitat Yonem A, Cakir B, Guler S, Azal OO, Corakci A. Effects of granulocyte-colony stimulating factor in the treatment of diabetic foot infection. Diabetes Obes Metab. 2001;3:332–7.PubMedCrossRef Yonem A, Cakir B, Guler S, Azal OO, Corakci A. Effects of granulocyte-colony stimulating factor in the treatment of diabetic foot infection. Diabetes Obes Metab. 2001;3:332–7.PubMedCrossRef
74.
Zurück zum Zitat Kastenbauer T, Hornlein B, Sokol G, Irsigler K. Evaluation of granulocyte-colony stimulating factor (Filgrastim) in infected diabetic foot ulcers. Diabetologia. 2003;46:27–30.PubMed Kastenbauer T, Hornlein B, Sokol G, Irsigler K. Evaluation of granulocyte-colony stimulating factor (Filgrastim) in infected diabetic foot ulcers. Diabetologia. 2003;46:27–30.PubMed
75.
Zurück zum Zitat Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997;38:563–76. discussion 577.PubMedCrossRef Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997;38:563–76. discussion 577.PubMedCrossRef
76.
Zurück zum Zitat Xie X, McGregor M, Dendukuri N. The clinical effectiveness of negative pressure wound therapy: a systematic review. J Wound Care 19:490–5. Xie X, McGregor M, Dendukuri N. The clinical effectiveness of negative pressure wound therapy: a systematic review. J Wound Care 19:490–5.
77.
Zurück zum Zitat Bee TK, Croce MA, Magnotti LJ, et al. Temporary abdominal closure techniques: a prospective randomized trial comparing polyglactin 910 mesh and vacuum-assisted closure. J Trauma. 2008;65:337–42. discussion 342-4.PubMedCrossRef Bee TK, Croce MA, Magnotti LJ, et al. Temporary abdominal closure techniques: a prospective randomized trial comparing polyglactin 910 mesh and vacuum-assisted closure. J Trauma. 2008;65:337–42. discussion 342-4.PubMedCrossRef
78.
Zurück zum Zitat Blume PA, Walters J, Payne W, Ayala J, Lantis J. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care. 2008;31:631–6.PubMedCrossRef Blume PA, Walters J, Payne W, Ayala J, Lantis J. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care. 2008;31:631–6.PubMedCrossRef
79.
Zurück zum Zitat Huang WS, Hsieh SC, Hsieh CS, Schoung JY, Huang T. Use of vacuum-assisted wound closure to manage limb wounds in patients suffering from acute necrotizing fasciitis. Asian J Surg. 2006;29:135–9.PubMedCrossRef Huang WS, Hsieh SC, Hsieh CS, Schoung JY, Huang T. Use of vacuum-assisted wound closure to manage limb wounds in patients suffering from acute necrotizing fasciitis. Asian J Surg. 2006;29:135–9.PubMedCrossRef
80.
Zurück zum Zitat Mody GN, Nirmal IA, Duraisamy S, Perakath B. A blinded, prospective, randomized controlled trial of topical negative pressure wound closure in India. Ostomy Wound Manage. 2008;54:36–46.PubMed Mody GN, Nirmal IA, Duraisamy S, Perakath B. A blinded, prospective, randomized controlled trial of topical negative pressure wound closure in India. Ostomy Wound Manage. 2008;54:36–46.PubMed
81.
Zurück zum Zitat Perez D, Bramkamp M, Exe C, von Ruden C and Ziegler A. Modern wound care for the poor: a randomized clinical trial comparing the vacuum system with conventional saline-soaked gauze dressings. Am J Surg. 199:14–20. Perez D, Bramkamp M, Exe C, von Ruden C and Ziegler A. Modern wound care for the poor: a randomized clinical trial comparing the vacuum system with conventional saline-soaked gauze dressings. Am J Surg. 199:14–20.
82.
Zurück zum Zitat Sepulveda G, Espindola M, Maureira M. et al [Negative-pressure wound therapy versus standard wound dressing in the treatment of diabetic foot amputation. A randomised controlled trial]. Cir Esp. 2009;86:171–7.PubMedCrossRef Sepulveda G, Espindola M, Maureira M. et al [Negative-pressure wound therapy versus standard wound dressing in the treatment of diabetic foot amputation. A randomised controlled trial]. Cir Esp. 2009;86:171–7.PubMedCrossRef
83.
Zurück zum Zitat Akbari A, Moodi H, Ghiasi F, Sagheb HM, Rashidi H. Effects of vacuum-compression therapy on healing of diabetic foot ulcers: randomized controlled trial. J Rehabil Res Dev. 2007;44:631–6.PubMedCrossRef Akbari A, Moodi H, Ghiasi F, Sagheb HM, Rashidi H. Effects of vacuum-compression therapy on healing of diabetic foot ulcers: randomized controlled trial. J Rehabil Res Dev. 2007;44:631–6.PubMedCrossRef
84.
Zurück zum Zitat Ubbink DT, Westerbos SJ, Evans D, Land L and Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database Syst Rev 2008:CD001898. Ubbink DT, Westerbos SJ, Evans D, Land L and Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database Syst Rev 2008:CD001898.
85.
Zurück zum Zitat Armstrong DG, Lavery LA. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366:1704–10.PubMedCrossRef Armstrong DG, Lavery LA. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366:1704–10.PubMedCrossRef
86.
Zurück zum Zitat Eginton MT, Brown KR, Seabrook GR, Towne JB, Cambria RA. A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds. Ann Vasc Surg. 2003;17:645–9.PubMedCrossRef Eginton MT, Brown KR, Seabrook GR, Towne JB, Cambria RA. A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds. Ann Vasc Surg. 2003;17:645–9.PubMedCrossRef
87.
Zurück zum Zitat Etoz A, Ozgenel Y, Ozcan M. The use of negative pressure wound therapy on diabetic foot ulcers: a preliminary controlled trial. Wounds. 2004;16:264–9. Etoz A, Ozgenel Y, Ozcan M. The use of negative pressure wound therapy on diabetic foot ulcers: a preliminary controlled trial. Wounds. 2004;16:264–9.
88.
Zurück zum Zitat McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch JM, Farinas LP. Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy Wound Manage. 2000;46:28–32. 34.PubMed McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch JM, Farinas LP. Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy Wound Manage. 2000;46:28–32. 34.PubMed
89.
Zurück zum Zitat Brown GL, Thomson PD, Mader JT, Hilton JG, Browne ME, Wells CH. Effects of hyperbaric oxygen upon S. aureus, Ps. aeruginosa and C. albicans. Aviat Space Environ Med. 1979;50:717–20.PubMed Brown GL, Thomson PD, Mader JT, Hilton JG, Browne ME, Wells CH. Effects of hyperbaric oxygen upon S. aureus, Ps. aeruginosa and C. albicans. Aviat Space Environ Med. 1979;50:717–20.PubMed
90.
Zurück zum Zitat Faglia E, Favales F, Aldeghi A, et al. Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. Diabetes Care. 1996;19:1338–43.PubMedCrossRef Faglia E, Favales F, Aldeghi A, et al. Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. Diabetes Care. 1996;19:1338–43.PubMedCrossRef
91.
Zurück zum Zitat Marx RE, Ehler WJ, Tayapongsak P, Pierce LW. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg. 1990;160:519–24.PubMedCrossRef Marx RE, Ehler WJ, Tayapongsak P, Pierce LW. Relationship of oxygen dose to angiogenesis induction in irradiated tissue. Am J Surg. 1990;160:519–24.PubMedCrossRef
92.
Zurück zum Zitat Brismar K, Lind F, Kratz G. Dose-dependent hyperbaric oxygen stimulation of human fibroblast proliferation. Wound Repair Regen. 1997;5:147–50.PubMedCrossRef Brismar K, Lind F, Kratz G. Dose-dependent hyperbaric oxygen stimulation of human fibroblast proliferation. Wound Repair Regen. 1997;5:147–50.PubMedCrossRef
93.
Zurück zum Zitat Reng JJ, Hussan MZ, Constant J, Hunt TK. Angiogenesis in wound healing. J Surg Pathol. 1998;3:1–7. Reng JJ, Hussan MZ, Constant J, Hunt TK. Angiogenesis in wound healing. J Surg Pathol. 1998;3:1–7.
94.
Zurück zum Zitat Abidia A, Laden G, Kuhan G, et al. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg. 2003;25:513–8.PubMedCrossRef Abidia A, Laden G, Kuhan G, et al. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg. 2003;25:513–8.PubMedCrossRef
95.
Zurück zum Zitat Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med. 1992;38:112–4. 111.PubMed Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med. 1992;38:112–4. 111.PubMed
96.
Zurück zum Zitat Londahl M, Katzman P, Hammarlund C, Nilsson A and Landin-Olsson M. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle-brachial index in patients with diabetes and chronic foot ulcers. Diabetologia. 54:65–8. Londahl M, Katzman P, Hammarlund C, Nilsson A and Landin-Olsson M. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle-brachial index in patients with diabetes and chronic foot ulcers. Diabetologia. 54:65–8.
97.
Zurück zum Zitat • Edwards J, Stapley S. Debridement of diabetic foot ulcers. Cochrane Database Syst Rev:CD003556. This review is a comprehensive synthesis of the literature on the myriad options available for debridement of diabetic foot ulcers. • Edwards J, Stapley S. Debridement of diabetic foot ulcers. Cochrane Database Syst Rev:CD003556. This review is a comprehensive synthesis of the literature on the myriad options available for debridement of diabetic foot ulcers.
98.
Zurück zum Zitat D’Hemecourt PA, Smiell JM, Karim MR. Sodium carboxymethyl cellulose aqueous-based gel vs becaplermin gel in patients with nonhealing lower extremity diabetic ulcers. Wounds. 1998;10:69–75. D’Hemecourt PA, Smiell JM, Karim MR. Sodium carboxymethyl cellulose aqueous-based gel vs becaplermin gel in patients with nonhealing lower extremity diabetic ulcers. Wounds. 1998;10:69–75.
99.
Zurück zum Zitat Jensen JL, Seeley J, Gillin B. Diabetic foot ulcerations. A controlled, randomized comparison of two moist wound healing protocols: Carrasyn Hydrogel Wound dressing and wet-to-moist saline gauze. Adv Wound Care. 1998;11:1–4.PubMed Jensen JL, Seeley J, Gillin B. Diabetic foot ulcerations. A controlled, randomized comparison of two moist wound healing protocols: Carrasyn Hydrogel Wound dressing and wet-to-moist saline gauze. Adv Wound Care. 1998;11:1–4.PubMed
100.
Zurück zum Zitat Markevich YO, McLeod-Roberts J, Mousley M and Melloy E. Maggot therapy for diabetic neuropathic foot wounds. In: Diabetologia: Proceedings of the 36th Annual Meeting of the European Association for the Study of Diabetes 2000;43: Suppl 1:A15. Markevich YO, McLeod-Roberts J, Mousley M and Melloy E. Maggot therapy for diabetic neuropathic foot wounds. In: Diabetologia: Proceedings of the 36th Annual Meeting of the European Association for the Study of Diabetes 2000;43: Suppl 1:A15.
101.
Zurück zum Zitat Piaggesi A, Schipani E, Campi F, et al. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial. Diabet Med. 1998;15:412–7.PubMedCrossRef Piaggesi A, Schipani E, Campi F, et al. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial. Diabet Med. 1998;15:412–7.PubMedCrossRef
102.
Zurück zum Zitat Vandeputte J, Gryson L. Diabetic foot infection controlled by immuno-modulating hydrogel containing 65%glycerine. Presentation of a clinical trial. 6th European Conference on Advances in Wound Managemen. Vol. 1997. Amsterdam, October 1996:50–3 Vandeputte J, Gryson L. Diabetic foot infection controlled by immuno-modulating hydrogel containing 65%glycerine. Presentation of a clinical trial. 6th European Conference on Advances in Wound Managemen. Vol. 1997. Amsterdam, October 1996:50–3
103.
Zurück zum Zitat Whalley A, Boulton AJM, Harding K, Van Acker K and Capillas R. Performance characteristics and safety of purilon gel versus intrasite using biatain non-adhesive dressing as secondary dressing in the treatment of diabetic foot ulcers. 11th European Tissue Repair Society Annual Conference. Vol. 49. Cardiff, Wales, 2001. Whalley A, Boulton AJM, Harding K, Van Acker K and Capillas R. Performance characteristics and safety of purilon gel versus intrasite using biatain non-adhesive dressing as secondary dressing in the treatment of diabetic foot ulcers. 11th European Tissue Repair Society Annual Conference. Vol. 49. Cardiff, Wales, 2001.
104.
Zurück zum Zitat Jull AB, Rodgers A and Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2008;CD005083. Jull AB, Rodgers A and Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2008;CD005083.
105.
Zurück zum Zitat Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia. 2008;63:44–6.PubMed Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia. 2008;63:44–6.PubMed
106.
Zurück zum Zitat Moghazy AM, Shams ME, Adly OA, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 89:276–81. Moghazy AM, Shams ME, Adly OA, et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 89:276–81.
Metadaten
Titel
From Ulcer to Infection: An Update on Clinical Practice and Adjunctive Treatments of Diabetic Foot Ulcers
verfasst von
C. Abad
N. Safdar
Publikationsdatum
01.10.2012
Verlag
Current Science Inc.
Erschienen in
Current Infectious Disease Reports / Ausgabe 5/2012
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-012-0283-3

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