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01.12.2011 | Original paper

Fruit and vegetable consumption is inversely associated with having pancreatic cancer

verfasst von: Rick J. Jansen, Dennis P. Robinson, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Mariza de Andrade, Ann L. Oberg, Traci J. Hammer, Kari G. Rabe, Kristin E. Anderson, Janet E. Olson, Rashmi Sinha, Gloria M. Petersen

Erschienen in: Cancer Causes & Control | Ausgabe 12/2011

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Abstract

Objective

Studies on fruit, vegetable, fiber, and grain consumption and pancreatic cancer risk are inconclusive. We used a clinic-based case–control study specifically designed to address limitations of both cohort and case–control studies to examine the relationship.

Methods

Participants were excluded who reported changing their diet within 5 years prior to study entry. And 384 rapidly ascertained cases and 983 controls (frequency matched on age (±5 years), race, sex, and residence) completed epidemiologic surveys and 144-item food frequency questionnaires. Odds ratios (OR) and 95% confidence intervals were calculated using logistic regression adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption.

Results

Comparing highest to lowest quintiles, we observed significant inverse associations (OR < 0.8) with significant trends (p _trend < 0.05) for citrus, melon, and berries, other fruits, dark green vegetables, deep yellow vegetables, tomato, other vegetables, dry bean and pea, insoluble fiber, soluble fiber, whole grains, and orange/grapefruit juice, and an increased association with non-whole grains. Results were similar after adjusting for diabetes or total sugar intake.

Conclusions

We provide evidence that lower consumption of fruits, vegetables, whole grains, and fiber is associated with having pancreatic cancer. This may have a role in developing prevention strategies.

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Titel: Fruit and vegetable consumption is inversely associated with having pancreatic cancer
verfasst von: Rick J. Jansen
Dennis P. Robinson
Rachael Z. Stolzenberg-Solomon
William R. Bamlet
Mariza de Andrade
Ann L. Oberg
Traci J. Hammer
Kari G. Rabe
Kristin E. Anderson
Janet E. Olson
Rashmi Sinha
Gloria M. Petersen
Publikationsdatum: 01.12.2011
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 12/2011
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-011-9838-0

Springer Medizin

Fruit and vegetable consumption is inversely associated with having pancreatic cancer