Erschienen in:
01.11.2005 | Short Report
Fulminant hepatic failure in a newborn with herpes simplex virus 2 infection
verfasst von:
Sascha Meyer, Gisela Enders, Ali Baghai, Günther Löffler, Ludwig Gortner, Sven Gottschling
Erschienen in:
European Journal of Pediatrics
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Ausgabe 11/2005
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Excerpt
Although effective antiviral therapies have been made available for neonatal herpes simplex virus (HSV) disease, recent data demonstrate that no progress has been made in decreasing the interval between onset of HSV symptoms and initiation of antiviral therapy [
4]. We report a case of fatal neonatal HSV 2 infection presenting with fulminant hepatic failure despite an uneventful medical history concerning maternal HSV 2 infection and caesarean section before rupture of the membranes for suspected maternal appendicitis. Neonatal HSV 2 infection via maternal viraemia must be taken into the differential diagnosis of acute liver failure in newborns despite an unremarkable medical history concerning HSV 2 infection. To improve outcome, early antiviral treatment is warranted in these infants. …