Background
Results
Characterization of cell lines under investigation
Cell line | Melanoma differentiation antigens | Cancer/testis antigens | |||
---|---|---|---|---|---|
gp100
|
tyrosinase
|
MART-1
|
MAGE-A3
|
NY-ESO
| |
MZ2
| - | - | - | + + |
-
|
D10
| + | + | + + | + + |
-
|
Me39
| - | - | + + | + + |
-
|
WM115
| - | - | + | + + |
-
|
RE
| - | - | - | + + |
-
|
Me59
| - | - | - | +/- |
-
|
Me67
| - | - | - | + + |
-
|
Na8
| - | - | - | - |
-
|
HBL
| + | + | + + | + + |
-
|
Cell line | NANOG | OCT4 | SOX2 |
---|---|---|---|
MZ2
| - | - | - |
D10
| + + | + | - |
Me39
| + + | + + | - |
WM115
| + | + | + |
RE
| + + | + + | - |
Me59
| - | + | - |
Me67
| + | - | - |
Na8
| - | - | - |
HBL
| + | - | - |
CD133 expression is detectable in metastatic melanoma cell lines
Cell line | CD133 | CD105 | CD146 | CD271 | CD117 |
---|---|---|---|---|---|
MZ2
| neg. | 86.41 | 73.92 | 99.74 | neg. |
D10
| 89.66 | 77.14 | 98.79 | neg. | neg. |
Me39
| 1.88 | 95.65 | 100.00 | 7.40 | neg. |
WM115
| neg. | 87.60 | 99.6 | 45.24 | neg. |
RE
| 3.11 | 74.84 | 98.31 | 59.96 | 1.28 |
Me59
| 1.00 | 75.55 | 36.40 | 2.72 | 18.95 |
Me67
| neg. | 75.94 | 73.76 | 10.75 | neg. |
Na8
| 1.05 | 97.22 | 0.67 | 82.54 | neg. |
HBL
| neg. | 22.66 | 30.08 | 2.32 | 99.46 |