Background
Methods
Study population
Anthropometrics, spirometry and 6-Minute Walk Test
CT imaging
Functional respiratory imaging
Statistical analyses
Results
Sex (M/F) | 16/8 |
---|---|
Age (years) | 24 ± 9 |
Body length (cm) | 169 ± 14 |
Body weight (kg) | 62.9 ± 14.9 |
BMI (kg/m2) | 21.81 ± 3.73 |
BMI z-score ≤ 21 years, n = 10 | − 0.22 [− 1.92; 1.37] |
ppFEV1 (%) | 71 ± 25 |
FRI versus CF-CT
FRI | CF-CT scores (%) | |||||
---|---|---|---|---|---|---|
BE | Mucus | BWT | Parenchyma | AT | Total | |
iVlobe at TLC (L) | NS | NS | NS | − 0.17* | NS | NS |
Sqrt of iVlobe at FRC (L) | NS | NS | 0.18* | NS | NS | NS |
Log of siVaw at TLC (mL/L) | 0.40*** | NS | 0.17* | 0.26*** | 0.23** | 0.35*** |
Log of siVaww at TLC (mL/L) | 0.30*** | 0.16* | 0.18* | 0.36*** | NS | 0.30*** |
Cube root of siRaw at TLC (kPa * s/L) | NS | NS | NS | − 0.21** | − 0.23** | − 0.15* |
AT at FRC (%) | 0.37*** | 0.35*** | 0.29*** | 0.21** | 0.38*** | 0.43*** |
Sqrt of TBV at TLC (mL/L) | NS | 0.41*** | 0.16* | 0.32*** | NS | 0.20* |
Sqrt of BV10% at TLC (%) | NS | 0.19* | NS | 0.37*** | NS | 0.16* |
BV5_10% at TLC (%) | 0.55*** | 0.43*** | 0.50*** | NS | 0.41*** | 0.57*** |
Square of BV5% at TLC (%) | − 0.22** | − 0.32*** | − 0.26*** | − 0.40*** | − 0.22** | − 0.34*** |
FRI versus classical clinical outcome measures
Spirometry (% predicted) | |||||
---|---|---|---|---|---|
FEV1 | FVC | Square of PEF | Sqrt of MEF25–75 | Log of MEF25 | |
FRI | |||||
iVlobe at TLC (L) | NS | NS | NS | NS | NS |
iVlobe at FRC (L) | − 0.72*** | − 0.43* | − 0.66*** | − 0.77*** | − 0.76*** |
Log of siVaw at TLC (mL/L) | NS | NS | NS | NS | NS |
Log of siVaww at TLC (mL/L) | NS | − 0.44* | NS | NS | NS |
Log of siRaw at TLC (kPa * s/L) | NS | NS | NS | NS | NS |
AT at FRC (%) | − 0.85*** | − 0.59** | − 0.76*** | − 0.88*** | − 0.84*** |
TBV at TLC (mL/L) | NS | NS | NS | NS | NS |
BV10% at TLC (%) | − 0.57** | − 0.51* | − 0.59** | − 0.58** | − 0.45* |
BV5_10% at TLC (%) | − 0.61** | − 0.59** | − 0.49* | − 0.54** | − 0.55** |
Square of BV5% at TLC (%) | 0.64*** | 0.57** | 0.62** | 0.61** | 0.52** |
CF-CT | |||||
Total score (%) | − 0.85*** | − 0.73*** | − 0.65*** | − 0.80*** | − 0.81*** |
Bronchiectasis (%) | − 0.77*** | − 0.70*** | − 0.51* | − 0.73*** | − 0.73*** |
Mucus plugging (%) | − 0.80*** | − 0.68*** | − 0.69*** | − 0.75*** | − 0.77*** |
BWT (%) | − 0.61** | − 0.58** | NS | − 0.50* | − 0.58** |
Parenchyma (%) | − 0.73*** | − 0.77*** | − 0.48* | − 0.66*** | − 0.66*** |
AT (%) | − 0.69*** | − 0.54** | − 0.61** | − 0.65*** | − 0.66*** |
6MWT | |||
---|---|---|---|
6MWD (m) | SpO2 start (%) | SpO2 end (%) | |
FRI | |||
iVlobe at TLC (L) | NS | NS | NS |
iVlobe at FRC (L) | NS | NS | − 0.69*** |
Log of siVaw at TLC (mL/L) | NS | NS | NS |
Log of siVaww at TLC (mL/L) | NS | NS | NS |
Log of siRaw at TLC (kPa*s/L) | NS | NS | NS |
AT at FRC (%) | − 0.85*** | NS | − 0.72*** |
TBV at TLC (mL/L) | NS | NS | NS |
BV10% at TLC (%) | NS | NS | − 0.59** |
BV5_10% at TLC (%) | NS | NS | − 0.60** |
Square of BV5% at TLC (%) | NS | NS | 0.53* |
CF-CT | |||
Total score | − 0.53* | NS | − 0.73*** |
Bronchiectasis | NS | NS | − 0.72*** |
Mucus plugging | NS | NS | − 0.66** |
BWT | NS | NS | NS |
Parenchyma | − 0.45* | NS | NS |
AT | NS | NS | − 0.71*** |