Gender differences in health-related quality of life of adolescents with cystic fibrosis

Cystic fibrosis (CF) is a genetic disorder that affects multiple organ systems. Treatments have improved overall survival so that those born today have a median life expectancy of approximately 40 years [1]. Much of the morbidity and mortality associated with cystic fibrosis is due to pulmonary disease, and investigations have shown that early, aggressive, and center-based care improves prognosis [2]. Objective clinical parameters, such as aerobic fitness, pulmonary function, nutritional status, and aggressive treatment with antibiotics, are associated with improved health outcomes [2]. In the past, clinical morbidity and mortality rates in children and adolescents were monitored as primary outcomes [3], but more recently, to provide the scientific basis for practice guidelines and to measure treatment effectiveness from patients' perspectives, there has been increasing focus on the examination of health-related quality of life (HRQOL) [4, 5], Thus, the Cystic Fibrosis Foundation and the National Heart, Lung, and Blood Institute recommend incorporating quality of life as an outcome measure for patients with CF [6]. In CF populations, the measurement of HRQOL is one approach that has been used to correlate clinical outcomes and the impact of both disease progression and treatments from patients' perspectives [7‐9].

Many factors have been shown to influence survival in patients with CF. Biologic and physiologic factors such as pancreatic insufficiency and pseudomonas infections, and socioeconomic factors such as inadequate or no health insurance are associated with decreased survival rates [2, 10, 11]. Britto found that, compared with the general population, patients with CF report lower physical health scores, independent of lung function, nutritional status or demographic factors [12]. Moreover, female patients with CF have been shown across age strata to have a shorter life expectancy, more serious respiratory infections, and Pseudomonas aeruginosa infections at a younger age than male patients, although the etiology of gender differences is unclear [13‐15]. Also, higher health values, including higher time tradeoff (TTO) scores, have been linked to male gender in patients with CF [16].

In other populations, studies have shown that gender plays a part in the way patients – including adolescents – perceive their own HRQOL and health status [17‐21, 30]. Adult female patients with chronic illnesses have reported poorer HRQOL than males in prior studies [22‐25]. Evidence suggests that, in general, men and women may respond differently to poor health and women may, in turn, report poorer general health than men [26‐30]. This difference has also been seen among adolescents. In one European study, adolescent females reported lower HRQOL with regard to physical health, mood, and self perception than adolescent males. [31] This difference was noted to have developed around age 12 and persisted through late adolescence.

Few studies have examined how the gender of patients with CF may impact their HRQOL when accounting for the severity of illness [32‐35]. With this investigation, we wanted to determine if gender differences exist in self-reported HRQOL in adolescents with CF. Our specific objectives were: 1) to determine if there are gender differences in HRQOL in adolescent patients with CF; and 2) to determine which HRQOL domains are associated with differences when stratified by gender, after controlling for markers of disease severity. We hypothesized that gender differences exist, with female adolescents reporting poorer HRQOL than males.

Ninety-eight adolescents aged 10–18 years completed the CF-87 (Table 1). The mean (SD) age was 14.6 (2.5) years; 50 (51.0%) were female; and the mean (SD) FEV₁ was 71.6% (25.6%) of predicted. There were no significant differences between males and females for age or FEV₁. Table 2 summarizes the mean, SD, range, and percent at the floor and ceiling for each scale.

Female patients with CF have been shown to have much shorter life expectancies than males with CF, with a median decrease of 4 years until the age of 20 [14, 44]. We sought to determine if gender differences exist for HRQOL for adolescent patients with CF.

In our cohort of adolescents with CF, significant gender differences in HRQOL existed between males and females. On average, female adolescents with CF scored lower on all health domains with the exception of the role behavior domain. Even when controlling for age and lung disease severity, female adolescents had significantly lower scores in mental health, global health, and perceptions of general health. Physical functioning was not related to gender when controlling for age and lung disease severity. This may indicate that age and disease severity is more important than gender in predicting physical aspects of HRQOL. In addition, the level of family activities, which may also be influenced by age of the patient and severity of lung disease, were no longer significant when controlling for those factors.

Previous research has found that female adolescents with CF have a more accurate perception of objective clinical health status than male adolescents [26], but rely more on denial to cope [45]. Such negative ways of coping can result in poor correlation between pulmonary function and general health perceptions. When compared to adolescent males, adolescent women, have also been found to use more of both positive and negative coping strategies to withstand pain [34, 46, 47]. Avoidance strategies may be viewed as 'negative' or maladaptive by health professionals if it means that patients avoid doing their treatments, but from the perspective of patients may be psychologically adaptive as a means to escape the world of CF for a while. Additionally, some studies have found that adolescent females report more physical health symptoms, psychological symptoms and use more emotion-oriented and problem oriented coping strategies than adolescent males. [48] Because coping styles may be associated with medication adherence, gender differences and coping skills need to be considered when correlating clinical markers with changes in HRQOL.

From a developmental psychology perspective, changes in HRQOL may be explained by hormonal development as well as a physical and social transition from childhood to adulthood. As adolescents transition, peer and social groups emerge, cognitive abilities develop, and they become more independent from their families. This stage of development may affect perceived physical health. Some have described that perceived health is determined by personal factors such as gender, school achievement, drug use, health behaviors, and the adolescents' environment, such as peer/parent relationships and the family's income [49]. Others have linked risk-taking behaviors to lower family income [50]. However, some data suggest that gender differences play a more significant role than class differences with regard to differences in health [51]. Similar to studies done in non-CF populations [31], we found gender differences among adolescents with CF in the areas of mental health and general health perceptions. Differences in physical functioning did not persist in this study possibly because body image also contributes to one's perception of physical health and physical functioning is linked to pulmonary function. Studies have shown little difference in body image between patients with CF and healthy age-matched controls [52]. Females more often overestimate their weight, while males underestimate their weight. A significantly greater proportion of males than females perceived their weight status as underweight and therefore, were more likely to take enteral supplements [53]. Willis and colleagues [54], found that young men and women with CF identify first as young men and women, rather than adults with CF. This combined with social desires to stay slender, has been suggested to contribute to non-adherence.

Powers [55] found that adolescents reported strong relationships between pulmonary function and self-reports of pain, general health, and school-activity limitations, but pulmonary function was not related to physical functioning, emotional or behavioral health. Perhaps because gender differences factor into global health, physical function, and general health perception among adolescents, such a relationship with pulmonary function is not established. In this study, female adolescents with CF reported poorer mental health, global health, and general health perceptions. Such gender differences might limit associations between pulmonary function and certain health domains when the effect of gender is not taken into account.

There are some limitations of this study. Although we recruited patients from 2 CF centers, the sample size was relatively small. A few of the health domains exhibited ceiling effects. The CHQ is a generic questionnaire used to measure HRQOL in diverse pediatric populations and may not have been able to detect small differences in HRQOL in patients with CF. Accordingly, the generalizability of our findings is uncertain. Because we examined HRQOL in two prior completed studies, we were unable to examine HRQOL differences in those who refused and those who agreed to participate. Patients with more severe disease (with greater likelihood of being females) may have participated in the study at disproportionately low rates when compared with healthier counterparts. For example, in our population, the overall FEV₁ was reflective of mild disease. Clinical variables, such as pseudomonal infection, nutrition status, and history of co morbidities such as diabetes, and social variables such as socioeconomic or insurance status, were not available for many observations and thus were not controlled for, which may partially explain the HRQOL differences we found between genders.

Multiple studies have shown that females, including adolescents, report poorer HRQOL than males [8, 18, 20, 56], often despite having similar objective clinical measures like pulmonary function. It is possible that such differences were based on perception of health, rather than actual health status. Females had poorer HRQOL in primarily the psychological domains of health, when controlling for disease severity and age. The psychological domains of health may potentially affect therapy and should be considered when treating female adolescents with cystic fibrosis. Other social constructs that affect adolescent skill building, including self-construct, self-efficacy, identity formation and social support may be responsible for overall health perceptions in adolescent males and females.

Gender differences in HRQOL appear to exist between adolescent males and females with CF. Further research will need to focus on the causes of such gender differences in HRQOL and on potential interventions to improve HRQOL for all adolescents living with CF.