Introduction
Materials and methods
Study subjects
DNA processing and genotyping
Statistical methods
Results
Hispanic | Non-Hispanic Whites | |||
---|---|---|---|---|
Cases | Controls | Cases | Controls | |
Total | 300 | 406 | 225 | 369 |
Age of child |
Mean
|
SD
|
Mean
|
SD
|
Mean
|
SD
|
Mean
|
SD
|
---|---|---|---|---|---|---|---|---|
Years | 5.6 | 3.6 | 5.5 | 3.6 | 5.6 | 3.4 | 5.7 | 3.8 |
Sex of child |
N
|
%
|
N
|
%
|
N
|
%
|
N
|
%
|
---|---|---|---|---|---|---|---|---|
Male | 156 | 52.0 | 214 | 52.7 | 125 | 55.6 | 221 | 59.9 |
Female | 144 | 48.0 | 192 | 47.3 | 100 | 44.4 | 148 | 40.1 |
Race of child | ||||||||
White | 114 | 38.0 | 116 | 28.6 | 225 | 100 | 369 | 100 |
African American | 2 | 0.7 | 0 | 0.0 | – | – | – | – |
Native American | 6 | 2.0 | 11 | 2.7 | – | – | – | – |
Asian/Pacific Islander | 0 | 0.0 | 3 | 0.7 | – | – | – | – |
Mixed/other | 178 | 59.3 | 276 | 68.0 | – | – | – | – |
Cytogenetic grouping (cases only) | ||||||||
Total B-cell precursor ALL | 279 | 93.0 | – | – | 202 | 89.8 | – | – |
B-cell precursor high-hyperdiploid ALL | 85 | 28.3 | – | – | 62 | 27.6 | – | – |
Gene | SNP | Minor allele | Non-Hispanic Whites | Hispanics | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MAFa (%) | Total ALL | B-cell | B-cell hyperdiploid | MAFa (%) | Total ALL | B-cell | B-cell hyperdiploid | |||||
Allelic ORb (CI) | Pc
| Allelic ORb (CI) | Allelic ORb (CI) | Allelic ORb (CI) | Pc
| Allelic ORb (CI) | Allelic ORb (CI) | |||||
ARID5B
| rs10994982 | A | 48 |
1.37 (1.08–1.73)
|
0.018
|
1.41 (1.10–1.80)
|
1.67 (1.14–2.47)
| 54 | 1.53 (1.23–1.90)
|
0.0004
|
1.65 (1.31–2.07)
|
2.21 (1.52–3.21)
|
ARID5B
| rs10740055 | C | 48 |
1.50 (1.18–1.90)
|
0.003
|
1.57 (1.23–2.02)
|
1.76 (1.19–2.61)
| 54 |
1.61 (1.29–2.00)
|
1 × 10
−5
|
1.72 (1.37–2.17)
|
2.43 (1.67–3.55)
|
ARID5B
| rs7073837 | A | 45 |
1.43 (1.11–1.85)
|
0.009
|
1.59 (1.20–2.11)
|
2.30 (1.48–3.59)
| 52 |
1.76 (1.39–2.23)
|
4.3 × 10
−7
|
2.23 (1.68–2.94)
|
2.66 (1.75–4.03)
|
ARID5B
| rs7089424 | G | 29 |
1.84 (1.43–2.37)
|
2.2 × 10
−6
|
1.98 (1.50–2.61)
|
2.71 (1.79–4.12)
| 39 |
1.98 (1.59–2.48)
|
1.0 × 10
−9
|
2.20 (1.72–2.81)
|
3.22 (2.18–4.73)
|
ARID5B
| rs10821936 | C | 31 |
1.79 (1.40–2.28)
|
4.8 × 10
−6
|
1.83 (1.42–2.36)
|
2.43 (1.64–3.61)
| 41 |
1.99 (1.61–2.47)
|
1.2 × 10
−9
|
2.15 (1.70–2.71)
|
3.08 (2.11–4.48)
|
CEBPE
| rs2239633 | C | 51 |
1.44 (1.13–1.82)
|
0.005
|
1.83 (1.42–2.36)
|
1.88 (1.25–2.82)
| 61 | 1.24 (0.99–1.55) | 0.0671 |
1.26 (1.00–1.58)
|
1.81 (1.24–2.66)
|
IKZF1
| rs11978267 | G | 27 |
1.81 (1.41–2.32)
|
7.8 × 10
−6
|
1.78 (1.37–2.30)
|
1.76 (1.18–2.62)
| 27 | 1.20 (0.95–1.51) | 0.1483 | 1.18 (0.93–1.50) | 1.21 (0.84–1.73) |
IKZF1
| rs4132601 | G | 27 |
1.80 (1.41–2.31)
|
8.4 × 10
−6
|
1.78 (1.37–2.30)
|
1.75 (1.18–2.61)
| 27 | 1.22 (0.97–1.54) | 0.08 | 1.21 (0.95–1.54) | 1.27 (0.88–1.82) |
CDKN2A
| rs3731217 | G | 14 | 0.71 (0.49–1.03) | 0.079 |
0.66 (0.44–0.99)
|
0.46 (0.22–0.95)
| 9 | 0.74 (0.50–1.11) | 0.162 | 0.70 (0.46–1.07) |
0.38 (0.16–0.89)
|
CDKN2A
| rs3218018 | C | 9 | 0.99 (0.67–1.48) | 0.966 | 0.99 (0.65–1.53) | 1.24 (0.66–2.32) | 6 | 1.78 (1.19–2.66)
|
0.0145
|
1.77 (1.18–2.66)
|
2.37 (1.40–4.00)
|
CDKN2A
| rs2811712 | G | 10 | 0.96 (0.66–1.41) | 0.921 | 1.05 (0.70–1.57) | 1.23 (0.33–2.25) | 8 |
1.56 (1.09–2.24)
|
0.0315
|
1.53 (1.06–2.22)
|
1.91 (1.17–3.11)
|
CDKN2A
| rs3731239 | C | 36 | 1.26 (0.95–1.55) | 0.163 |
1.32 (1.02–1.71)
|
1.55 (1.05–2.29)
| 32 | 0.97 (0.74–1.27) | 0.7407 | 0.99 (0.74–1.31) | 1.04 (0.68–1.58) |
CDKN2A
| rs4074785 | A | 10 | 0.90 (0.59–1.38) | 0.623 | 1.03 (0.66–1.60) | 0.92 (0.45–1.88) | 29 | 0.96 (0.76–1.22) | 0.633 | 1.00 (0.78–1.28) | 0.96 (0.65–1.41) |