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Erschienen in: Medicine, Health Care and Philosophy 3/2013

01.08.2013 | Scientific Contribution

Genetics and psychiatry: a proposal for the application of the precautionary principle

Erschienen in: Medicine, Health Care and Philosophy | Ausgabe 3/2013

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Abstract

The paper suggests an application of the precautionary principle to the use of genetics in psychiatry focusing on scientific uncertainty. Different levels of uncertainty are taken into consideration—from the acknowledgement that the genetic paradigm is only one of the possible ways to explain psychiatric disorders, via the difficulties related to the diagnostic path and genetic methods, to the value of the results of studies carried out in this field. Considering those uncertainties, some measures for the use of genetics in psychiatry are suggested. Some of those measures are related to the conceptual limits of the genetic paradigm; others are related to present knowledge and should be re-evaluated.
Literatur
Zurück zum Zitat American Psychiatric Association. 1994. DSM-IV Diagnostic and statistical manual of mental disorders. Fourth edition. Washington D.C: American Psychiatric Press. American Psychiatric Association. 1994. DSM-IV Diagnostic and statistical manual of mental disorders. Fourth edition. Washington D.C: American Psychiatric Press.
Zurück zum Zitat Arribas-Ayllon, M., A. Bartlett, and K. Featherstone. 2010. Complexity and accountability: The witches’ brew of psychiatric genetics. Social Studies of Science 40(4): 499–524.PubMedCrossRef Arribas-Ayllon, M., A. Bartlett, and K. Featherstone. 2010. Complexity and accountability: The witches’ brew of psychiatric genetics. Social Studies of Science 40(4): 499–524.PubMedCrossRef
Zurück zum Zitat Borgna, E. 2003. Le intermittenze del cuore. Milano: Feltrinelli. Particularly chapter 1 Paesaggi invisibili (pp. 9–14). Borgna, E. 2003. Le intermittenze del cuore. Milano: Feltrinelli. Particularly chapter 1 Paesaggi invisibili (pp. 9–14).
Zurück zum Zitat Civita, A. 1990. Ricerche filosofiche sulla psichiatria. Milano: Guerini. Civita, A. 1990. Ricerche filosofiche sulla psichiatria. Milano: Guerini.
Zurück zum Zitat Civita, A. 1999. Psicopatologia. Un’introduzione storica. Roma: Carocci (Appendix 3). Civita, A. 1999. Psicopatologia. Un’introduzione storica. Roma: Carocci (Appendix 3).
Zurück zum Zitat Commission of the European Communities. 2000. Communication from the Commission on the precautionary principle. Bruxelles. Commission of the European Communities. 2000. Communication from the Commission on the precautionary principle. Bruxelles.
Zurück zum Zitat Council of Europe. 1997. Convention on human rights and biomedicine. Oviedo. Council of Europe. 1997. Convention on human rights and biomedicine. Oviedo.
Zurück zum Zitat Cowan, W.M., K.L. Kopnisky, and S.E. Hyman. 2002. The human genome project and its impact on psychiatry. Annual Review on Neuroscience 25: 1–50.CrossRef Cowan, W.M., K.L. Kopnisky, and S.E. Hyman. 2002. The human genome project and its impact on psychiatry. Annual Review on Neuroscience 25: 1–50.CrossRef
Zurück zum Zitat Dick, D.M., B. Riley, and K.S. Kendler. 2010. Nature and nurture in neuropsychiatric genetics: Where do we stand? Dialogues in Clinical Neurosciences 12(1): 7–23. Dick, D.M., B. Riley, and K.S. Kendler. 2010. Nature and nurture in neuropsychiatric genetics: Where do we stand? Dialogues in Clinical Neurosciences 12(1): 7–23.
Zurück zum Zitat European Commission. 2004. 25 recommendations on the ethical, legal and social implications of genetic testing. Bruxelles. European Commission. 2004. 25 recommendations on the ethical, legal and social implications of genetic testing. Bruxelles.
Zurück zum Zitat European Commission. 2007. Taking European knowledge society seriously. Report of the expert group on science and governance to the Science, Economy and Society Directorate, Directorate-General for Research, European Commission. Bruxelles. European Commission. 2007. Taking European knowledge society seriously. Report of the expert group on science and governance to the Science, Economy and Society Directorate, Directorate-General for Research, European Commission. Bruxelles.
Zurück zum Zitat European Group on Ethics in Science and New Technologies to the European Commission. 2003. Opinion on the ethical aspects of genetic testing in the workplace. Opinion n.18. Bruxelles. European Group on Ethics in Science and New Technologies to the European Commission. 2003. Opinion on the ethical aspects of genetic testing in the workplace. Opinion n.18. Bruxelles.
Zurück zum Zitat Forzano, F., P. Borry, A. Cambon-Thomsen, S.V. Hodgson, A. Tibben, P. de Vries, et al. 2010. Italian appeal court: A genetic predisposition to commit murder? European Journal of Human Genetics 18: 519–521.PubMedCrossRef Forzano, F., P. Borry, A. Cambon-Thomsen, S.V. Hodgson, A. Tibben, P. de Vries, et al. 2010. Italian appeal court: A genetic predisposition to commit murder? European Journal of Human Genetics 18: 519–521.PubMedCrossRef
Zurück zum Zitat Human Genetics Commission. 2010. A common framework of principles for direct-to-consumer genetic testing services. London: Human Genetics Commission. Human Genetics Commission. 2010. A common framework of principles for direct-to-consumer genetic testing services. London: Human Genetics Commission.
Zurück zum Zitat Lakoff, A. 2005. Pharmaceutical reason. Knowledge and value in global psychiatry. Cambridge: University Press UK.CrossRef Lakoff, A. 2005. Pharmaceutical reason. Knowledge and value in global psychiatry. Cambridge: University Press UK.CrossRef
Zurück zum Zitat Lewontin, R. 1992. Chapter 2. All in the genes? In Biology as ideology. The doctrine of DNA. New York: Harper Perennial. (pp. 17–37). Lewontin, R. 1992. Chapter 2. All in the genes? In Biology as ideology. The doctrine of DNA. New York: Harper Perennial. (pp. 17–37).
Zurück zum Zitat Lewontin, R., S. Rose, L. Kamin, 1984. Not in our genes. New York: Pantheon books. Particularly chapter 8 Schizophrenia: the clash of determinisms (pp. 197–231). Lewontin, R., S. Rose, L. Kamin, 1984. Not in our genes. New York: Pantheon books. Particularly chapter 8 Schizophrenia: the clash of determinisms (pp. 197–231).
Zurück zum Zitat Liberatore, A., and S. Funtowicz. 2003. Democratising expertise, expertising democracy: What does this mean, and why bother? Science and Public Policy 30(3): 146–150.CrossRef Liberatore, A., and S. Funtowicz. 2003. Democratising expertise, expertising democracy: What does this mean, and why bother? Science and Public Policy 30(3): 146–150.CrossRef
Zurück zum Zitat McMahon, F.J., N. Akula, T.G. Schulze, P. Muglia, F. Tozzi, S.D. Detera-Wadleigh, et al. 2010. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nature Genetics 42(2): 128–131.PubMedCrossRef McMahon, F.J., N. Akula, T.G. Schulze, P. Muglia, F. Tozzi, S.D. Detera-Wadleigh, et al. 2010. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nature Genetics 42(2): 128–131.PubMedCrossRef
Zurück zum Zitat National Institute of Mental Health’s Genetics Workgroup. 1999. Report. Biological Psychiatry 45: 559–602. National Institute of Mental Health’s Genetics Workgroup. 1999. Report. Biological Psychiatry 45: 559–602.
Zurück zum Zitat Nuffield Council on Bioethics. 1998. Mental disorders and genetics: the ethical context. London: Nuffield Council on Bioethics. Nuffield Council on Bioethics. 1998. Mental disorders and genetics: the ethical context. London: Nuffield Council on Bioethics.
Zurück zum Zitat Nuffield Council on Bioethics. 2002. Genetics and human behaviour: the ethical context. London: Nuffield Council on Bioethics. Nuffield Council on Bioethics. 2002. Genetics and human behaviour: the ethical context. London: Nuffield Council on Bioethics.
Zurück zum Zitat Nuffield Council on Bioethics. 2003. Pharmacogenetics. Ethical issues. London: Nuffield Council on Bioethics. Nuffield Council on Bioethics. 2003. Pharmacogenetics. Ethical issues. London: Nuffield Council on Bioethics.
Zurück zum Zitat Nöthen, M.M., V. Nieratschker, S. Cichon, and M. Rietschel. 2010. New findings in the genetics of major psychoses. Dialogues in Clinical Neurosciences 12(1): 85–93. Nöthen, M.M., V. Nieratschker, S. Cichon, and M. Rietschel. 2010. New findings in the genetics of major psychoses. Dialogues in Clinical Neurosciences 12(1): 85–93.
Zurück zum Zitat Owen, M.J., A.G. Cardno, and M.C. O’Donovan. 2000. Psychiatric genetics: Back to the future. Mol Psychiatry 5(1): 22–31.PubMedCrossRef Owen, M.J., A.G. Cardno, and M.C. O’Donovan. 2000. Psychiatric genetics: Back to the future. Mol Psychiatry 5(1): 22–31.PubMedCrossRef
Zurück zum Zitat Plomin, R., J.C. DeFries, G.E. McClearn, and P. McGuffin. 2001. Behavioral genetics, 4th ed. New York: Worth Publishers. Plomin, R., J.C. DeFries, G.E. McClearn, and P. McGuffin. 2001. Behavioral genetics, 4th ed. New York: Worth Publishers.
Zurück zum Zitat Psychiatric GWAS Consortium Coordinating Committee. 2009. Genomewide association studies: History, rationale, and prospects for psychiatric disorders. The American Journal of Psychiatry 166: 540–556.CrossRef Psychiatric GWAS Consortium Coordinating Committee. 2009. Genomewide association studies: History, rationale, and prospects for psychiatric disorders. The American Journal of Psychiatry 166: 540–556.CrossRef
Zurück zum Zitat Rutter, M., A. Pickles, R. Murray, and L. Eaves. 2001. Testing hypotheses on specific environmental causal effects on behaviour. Psychological Bulletin 127: 291–324.PubMedCrossRef Rutter, M., A. Pickles, R. Murray, and L. Eaves. 2001. Testing hypotheses on specific environmental causal effects on behaviour. Psychological Bulletin 127: 291–324.PubMedCrossRef
Zurück zum Zitat Rutter, M., and R. Plomin. 1997. Opportunities for psychiatry from genetic findings. The British Journal of Psychiatry 171(9): 209–219.PubMedCrossRef Rutter, M., and R. Plomin. 1997. Opportunities for psychiatry from genetic findings. The British Journal of Psychiatry 171(9): 209–219.PubMedCrossRef
Zurück zum Zitat Sartorius, N. 2006. Lessons from a 10-year global programme against stigma and discrimination because of an illness. Psychology, Health and Medicine 11(3): 383–388.CrossRef Sartorius, N. 2006. Lessons from a 10-year global programme against stigma and discrimination because of an illness. Psychology, Health and Medicine 11(3): 383–388.CrossRef
Zurück zum Zitat Shyn, S.I., J. Shi, J.B. Kraft, J.B. Potash, J.A. Knowles, M.M. Weissman, et al. 2011. Novel loci for major depression identified by genome-wide association study of sequenced treatment alternatives to relieve depression and meta-analysis of three studies. Molecular Psychiatry 16: 202–215.PubMedCrossRef Shyn, S.I., J. Shi, J.B. Kraft, J.B. Potash, J.A. Knowles, M.M. Weissman, et al. 2011. Novel loci for major depression identified by genome-wide association study of sequenced treatment alternatives to relieve depression and meta-analysis of three studies. Molecular Psychiatry 16: 202–215.PubMedCrossRef
Zurück zum Zitat Simon, C. 1997. Mad house: growing up in the shadow of mentally ill siblings. New York City: Doubleday. Adapted from the book. In National Institute of Mental Health’s Genetics Workgroup. Report. Biological Psychiatry 45: 559–602. p. 560. Simon, C. 1997. Mad house: growing up in the shadow of mentally ill siblings. New York City: Doubleday. Adapted from the book. In National Institute of Mental Health’s Genetics Workgroup. Report. Biological Psychiatry 45: 559–602. p. 560.
Zurück zum Zitat Sullivan, P.F., M.C. Neale, and K.S. Kendler. 2000. Genetic epidemiology of major depression: Review and meta-analysis. The American Journal of Psychiatry 157: 1552–1562.PubMedCrossRef Sullivan, P.F., M.C. Neale, and K.S. Kendler. 2000. Genetic epidemiology of major depression: Review and meta-analysis. The American Journal of Psychiatry 157: 1552–1562.PubMedCrossRef
Zurück zum Zitat Uher, R., N. Perroud, M.Y. Ng, J. Hauser, N. Henigsberg, W. Maier, et al. 2010. Genome-wide pharmacogenetics of antidepressant response in the GENDEP Project. The American Journal of Psychiatry 167: 555–564.PubMedCrossRef Uher, R., N. Perroud, M.Y. Ng, J. Hauser, N. Henigsberg, W. Maier, et al. 2010. Genome-wide pharmacogenetics of antidepressant response in the GENDEP Project. The American Journal of Psychiatry 167: 555–564.PubMedCrossRef
Zurück zum Zitat UNESCO. 1997. Universal declaration on human genome and human rights. Paris: UNESCO. UNESCO. 1997. Universal declaration on human genome and human rights. Paris: UNESCO.
Zurück zum Zitat United Nation. 1992. The Rio declaration on environment and development. Rio de Janeiro: United Nation. United Nation. 1992. The Rio declaration on environment and development. Rio de Janeiro: United Nation.
Zurück zum Zitat World Health Organization. 2001. The world health report 2001. Mental health. New understanding, new hope. Geneva. Particularly chapter 2 Burden of mental and behavioural disorders (pp. 19–44). World Health Organization. 2001. The world health report 2001. Mental health. New understanding, new hope. Geneva. Particularly chapter 2 Burden of mental and behavioural disorders (pp. 19–44).
Metadaten
Titel
Genetics and psychiatry: a proposal for the application of the precautionary principle
Publikationsdatum
01.08.2013
Erschienen in
Medicine, Health Care and Philosophy / Ausgabe 3/2013
Print ISSN: 1386-7423
Elektronische ISSN: 1572-8633
DOI
https://doi.org/10.1007/s11019-012-9408-6

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