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International Archives of Occupational and Environmental Health

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01.06.2010 | Original Article

Genotoxicity surveillance programme in workers dismantling World War I chemical ammunition

verfasst von: R. A. Mateuca, C. Carton, M. Roelants, S. Roesems, D. Lison, M. Kirsch-Volders

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 5/2010

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Abstract

Purpose

To evaluate the effectiveness of personal protective measures in a dismantling plant for chemical weapons from World War I of the Belgian Defence.

Methods

Seventeen NIOSH level B-equipped plant workers exposed to arsenic trichloride (AsCl₃) in combination with phosgene or hydrogen cyanide (HCN) were compared to 24 NIOSH level C-protected field workers occasionally exposed to genotoxic chemicals (including AsCl₃-phosgene/HCN) when collecting chemical ammunition, and 19 matched referents. Chromosomal aberrations (CA), micronuclei (MNCB and MNMC), sister chromatid exchanges (SCE) and high frequency cells (HFC) were analysed in peripheral blood lymphocytes. Urinary arsenic levels and genetic polymorphisms in major DNA repair enzymes (hOGG1 ³²⁶ , XRCC1 ³⁹⁹ , XRCC3 ²⁴¹) were also assessed.

Results

SCE and HFC levels were significantly higher in plant-exposed versus referent subjects, but MNCB and MNMC were not different. MNCB, SCE and HFC levels were significantly higher and MNMC levels significantly lower in field-exposed workers versus referents. AsCl₃ exposure was not correlated with genotoxicity biomarkers.

Conclusions

Protective measures for plant-exposed workers appear adequate, but protection for field-exposed individuals could be improved.

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Titel: Genotoxicity surveillance programme in workers dismantling World War I chemical ammunition
verfasst von: R. A. Mateuca
C. Carton
M. Roelants
S. Roesems
D. Lison
M. Kirsch-Volders
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 5/2010
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-010-0526-2

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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