nach oben

Erschienen in:

08.10.2018 | Research Letter

Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis

verfasst von: Vincenzo De Sanctis, Ashraf T. Soliman, Duran Canatan, Salvatore Di Maio, Heba Elsedfy, Alaa Baioumi, Christos Kattamis

Erschienen in: Endocrine | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Excerpt

Although spontaneous fertility can occur in well-transfused and well-chelated patients, with β-thalassemia major (β-ΤΜ), the majority are sub fertile due to hypogonadotropic hypogonadism (HH), secondary to transfusional haemosiderosis [1]. Ιn several studies, 40 to 80% of β-ΤΜ patients reported to have arrested puberty, pubertal failure, sexual dysfunction, and infertility [1, 2]. …

V. De Sanctis, A.T. Soliman, H. Elsedfy, S. Di Maio, D. Canatan, N. Soliman, M. Karimi, C. Kattamis, Gonadal dysfunction in adult male patients with thalassemia major: an update for clinicians caring for thalassemia. Expert. Rev. Hematol. 10(12), 1095–1106 (2017)CrossRefPubMed

V. De Sanctis, H. Elsedfy, A.T. Soliman, I.Z. Elhakim, A. Pepe, C. Kattamis, N.A. Soliman, R. Elalaily, M. El Kholy, M. Yassin, Acquired hypogonadotropic hypogonadism (AHH) in thalassaemia major patients: an underdiagnosed condition? Mediterr. J. Hematol. Infect. Dis. https://doi.org/10.4084/MJHID.2016.001 (2016).

P.Y. Liu, H.W. Baker, V. Jayadev, M. Zacharin, A.J. Conway, D.J. Handelsman, Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin-deficient infertile men: predictors of fertility outcome. J. Clin. Endocrinol. Metab. 94(3), 801–808 (2009)CrossRefPubMed

L. Yang, S.X. Zhang, Q. Dong, Z.B. Xiong, X. Li, Application of hormonal treatment in hypogonadotropic hypogonadism: more than ten years experience. Int. Urol. Nephrol. 44(2), 393–399 (2012)CrossRefPubMed

P.M. Bouloux, E. Nieschlag, H.G. Burger, N.E. Skakkebaek, F.C. Wu, D.J. Handelsman, G.H. Baker, R. Ochsenkuehn, A. Syska, R.I. McLachlan, A. Giwercman, A.J. Conway, L. Turner, J.H. van Kuijk, G. Voortman, Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. J. Androl. 24(4), 604–611 (2003)CrossRefPubMed

V. De Sanctis, C. Vullo, M. Katz, B. Wonke, C. Nannetti, B. Bagni, Induction of spermatogenesis in thalassaemia. Fertil. Steril. 50(6), 969–975 (1988)CrossRefPubMed

C. Ho, M. Zacharin, Fertility preservation in an adolescent boy: inducing puberty and spermatogenesis prior to elective, non-urgent bone marrow transplantation. Bone Marrow Transplant. 52(5), 792–793 (2017)CrossRefPubMed

T.G. Cooper, E. Noonan, S. von Eckardstein, J. Auger, H.W. Baker, H.M. Behre, T.B. Haugen, T. Kruger, C. Wang, M.T. Mbizvo, K.M. Vogelsong, World Health Organization reference values for human semen characteristics. Hum. Reprod. Update 16(3), 231–245 (2010).CrossRefPubMed

A.A. Dwyer, G.P. Sykiotis, F.J. Hayes, P.A. Boepple, H. Lee, K.R. Loughlin, M. Dym, P.M. Sluss, W.F. Crowley Jr, N. Pitteloud, Trial of recombinant follicle-stimulating hormone pretreatment for GnRH-induced fertility in patients with congenital hypogonadotropic hypogonadism. J. Clin. Endocrinol. Metab. 98(11), E1790–E1795 (2013)CrossRefPubMedPubMedCentral

10.

S. Bhasin, G.R. Cunningham, F.J. Hayes, A.M. Matsumoto, P.J. Snyder, R.S. Swerdloff, V.M. Montori, Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 95(6), 2536–2559 (2010)CrossRefPubMed

11.

S.T. Singer, D. Killilea, J.H. Suh, Z.J. Wang, Q. Yuan, K. Ivani, P. Evans, E. Vichinsky, R. Fischer, J.F. Smith, Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis. Am. J. Hematol. 90(9), E190–E192 (2015)CrossRefPubMedPubMedCentral

12.

G. Wang, M.P. Hardy, Development of Leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation. Biol. Reprod. 70(3), 632–639 (2004)CrossRefPubMed

13.

C. Kraus, Male infertility: pathogenesis and clinical diagnosis. Best. Pract. Res. Clin. Endocrinol. Metab. 25(2), 271–285 (2011)CrossRef

14.

D.W. Warne, G. Decosterd, H. Okada, Y. Yano, N. Koide, C.M. Howles, A combined analysis of data to identify predictive factors for spermatogenesis in men with hypogonadotropic hypogonadism treated with recombinant human follicle stimulating hormone and human chorionic gonadotropin. Fertil. Steril. 92(2), 594–604 (2009)CrossRefPubMed

15.

A.S. Burris, H.W. Rodbard, S.J. Winters, R.J. Sherins, Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size. J. Clin. Endocrinol. Metab. 66(6), 1144–1151 (1988)CrossRefPubMed

16.

D.M. de Kretser, J.B. Kerr, C.A. Paulsen, The peritubular tissue in the normal and pathological human testis. Ultrastruct. Study Biol. Reprod. 12(3), 317–324 (1975)CrossRef

17.

W.O. Maddock, W.O. Nelson, The effects of chorionic gonadotropin in adult men: increased estrogen and 17-ketosteroid excretion, gynecomastia, leydig cell stimulation and semi-niferous tubule damage. J. Clin. Endocrinol. Metab. 12(8), 985–1014 (1952)CrossRefPubMed

18.

P.A. Kumar, N. Pitteloud, P.A. Andrews, A. Dwyer, F. Hayes, W.F. Crowley Jr, M. Dym, Testis morphology in patients with idiopathic hypogonadotropic hypogonadism. Hum. Reprod. 21(4), 1033–1040 (2006)CrossRefPubMed

19.

A. Soliman, V. De Sanctis, H. Elsedfy, M. Yassin, N. Skordis, M. Karimi, P. Sobti, G. Raiola, M. El Kholy, Growth hormone deficiency in adults with thalassemia: an overview and the I-CET recommendations. Georgian Med. News 222, 79–88 (2013)

20.

N. Magon, S. Singh, A. Saxena, R. Sahay, Growth hormone in male infertility. Indian J. Endocrinol. Metab. 15(Suppl 3), S248–S249 (2011)CrossRefPubMedPubMedCentral

Titel: Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis
verfasst von: Vincenzo De Sanctis
Ashraf T. Soliman
Duran Canatan
Salvatore Di Maio
Heba Elsedfy
Alaa Baioumi
Christos Kattamis
Publikationsdatum: 08.10.2018
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-018-1772-4

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis

Excerpt

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2019

18F-FDG PET reveals an adrenocortical carcinoma in a bilateral adrenal multinodular disease

Role of kisspeptin and Kiss1R in the regulation of prolactin gene expression in rat somatolactotroph GH3 cells

Oral glucose load and mixed meal feeding lowers testosterone levels in healthy eugonadal men

Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women

Quo vadis Endocrine—Part II

Analysis of risk factors of metabolic syndrome using a structural equation model: a cohort study

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin