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Erschienen in: Indian Journal of Hematology and Blood Transfusion 2/2017

06.09.2016 | Correspondence

Growth Factor Variation in Two Types of Autologous Platelet Biomaterials: PRP Versus PRF

verfasst von: Satyam Arora, Urvershi Kotwal, Mitu Dogra, Veena Doda

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 2/2017

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Abstract

Autologous platelet biomaterials represent a key source of cytokines and growth factors extensively used for clinical and surgical applications involving tissue regeneration; wound healing and tissue repair. In this communication we discuss the growth factors released by activated platelet rich plasma (PRP) and platelet rich fibrin (PRF) releasate. Our study highlights that significantly higher growth factors (TGF-ß1) are released by activated PRP as compared to releasate of PRF. The various growth factors released by both platelet products are significantly higher than the baseline concentration in the whole blood and have different bio-mechanism hence should be individualized as per the clinical indication.
Literatur
1.
Zurück zum Zitat Intini G (2009) The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials 30:4956–4966CrossRefPubMed Intini G (2009) The use of platelet-rich plasma in bone reconstruction therapy. Biomaterials 30:4956–4966CrossRefPubMed
2.
Zurück zum Zitat Demidova-Rice TN, Wolf L, Deckenback J, Hamblin MR, Herman IM (2012) Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo. PLoS One 7:e32CrossRef Demidova-Rice TN, Wolf L, Deckenback J, Hamblin MR, Herman IM (2012) Human platelet-rich plasma- and extracellular matrix-derived peptides promote impaired cutaneous wound healing in vivo. PLoS One 7:e32CrossRef
3.
Zurück zum Zitat Murphy MB, Blashki D, Buchanan RM, Iman KY, Ferrari M, Simmons PJ et al (2012) Adult and umbilical cord blood-derived platalet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation. Biomaterials 33:5308–5316CrossRefPubMed Murphy MB, Blashki D, Buchanan RM, Iman KY, Ferrari M, Simmons PJ et al (2012) Adult and umbilical cord blood-derived platalet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation. Biomaterials 33:5308–5316CrossRefPubMed
4.
Zurück zum Zitat Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georfeff KR (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Pathol Oral Radiol Endodontol 85:638–646CrossRef Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georfeff KR (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Pathol Oral Radiol Endodontol 85:638–646CrossRef
5.
Zurück zum Zitat Sammartino G, Tia M, Marenzi G, di Lauro AE, D’Agostino E, Claudio PP (2005) Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J Oral Maxillofac Surg 63:766–770CrossRefPubMed Sammartino G, Tia M, Marenzi G, di Lauro AE, D’Agostino E, Claudio PP (2005) Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J Oral Maxillofac Surg 63:766–770CrossRefPubMed
6.
Zurück zum Zitat Arora S, Doda V, Kotwal U, Dogra M (2016) Quantification of platelet and platelet derived growth factors from platelet-rich-plasma (PRP) prepared at different centrifugal force (g) and time. Transfus Apheres Sci 54:103–110CrossRef Arora S, Doda V, Kotwal U, Dogra M (2016) Quantification of platelet and platelet derived growth factors from platelet-rich-plasma (PRP) prepared at different centrifugal force (g) and time. Transfus Apheres Sci 54:103–110CrossRef
7.
8.
Zurück zum Zitat Roberts AB (1993) Physiological actions and clinical applications of transforming growth factor-B (TGF-B). Growth Factors 8:1–9CrossRefPubMed Roberts AB (1993) Physiological actions and clinical applications of transforming growth factor-B (TGF-B). Growth Factors 8:1–9CrossRefPubMed
9.
Zurück zum Zitat Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL (2003) Growth factors in the treatment of diabetic foot ulcers. Br J Surg 90:133CrossRefPubMed Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL (2003) Growth factors in the treatment of diabetic foot ulcers. Br J Surg 90:133CrossRefPubMed
10.
Zurück zum Zitat Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 101:e37–e44CrossRef Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 101:e37–e44CrossRef
11.
Zurück zum Zitat Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G et al (2012) Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol 13:1231–1256CrossRefPubMed Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G et al (2012) Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol 13:1231–1256CrossRefPubMed
12.
Zurück zum Zitat Kasperk C, Werdegal JE, Mohan S et al (1990) Interaction of growth factors present in bone matrix and bone cells: effects on DNA synthesis and alkaline phosphatase. Growth Factors 3:147–154CrossRefPubMed Kasperk C, Werdegal JE, Mohan S et al (1990) Interaction of growth factors present in bone matrix and bone cells: effects on DNA synthesis and alkaline phosphatase. Growth Factors 3:147–154CrossRefPubMed
13.
Zurück zum Zitat Howes R, Bowness JM, Grotendorst GR et al (1988) PDGF enhances demineralised bone matrix-induced cartilage and bone formation. Calcif Tissue Int 42:34–38CrossRefPubMed Howes R, Bowness JM, Grotendorst GR et al (1988) PDGF enhances demineralised bone matrix-induced cartilage and bone formation. Calcif Tissue Int 42:34–38CrossRefPubMed
14.
Zurück zum Zitat Assoian RK, Komoriya A, Meyers CA et al (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification and characterization. J Biol Chem 258:7155–7160PubMed Assoian RK, Komoriya A, Meyers CA et al (1983) Transforming growth factor-beta in human platelets. Identification of a major storage site, purification and characterization. J Biol Chem 258:7155–7160PubMed
15.
Zurück zum Zitat Schär MO, Diaz-Romero J, Kohl S, Zumstein MA, Nesic D (2015) Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res 473(5):1635–1643CrossRefPubMedPubMedCentral Schär MO, Diaz-Romero J, Kohl S, Zumstein MA, Nesic D (2015) Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res 473(5):1635–1643CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Passaretti F, Tia M, D’Esposito V, De Pascale M, Del Corso M, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, Sammartino G (2014) Growth-promoting action and growth factor release by different platelet derivatives. Platelets 25(4):252–256CrossRefPubMed Passaretti F, Tia M, D’Esposito V, De Pascale M, Del Corso M, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, Sammartino G (2014) Growth-promoting action and growth factor release by different platelet derivatives. Platelets 25(4):252–256CrossRefPubMed
Metadaten
Titel
Growth Factor Variation in Two Types of Autologous Platelet Biomaterials: PRP Versus PRF
verfasst von
Satyam Arora
Urvershi Kotwal
Mitu Dogra
Veena Doda
Publikationsdatum
06.09.2016
Verlag
Springer India
Erschienen in
Indian Journal of Hematology and Blood Transfusion / Ausgabe 2/2017
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-016-0721-8

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