Background
Methods
Results
Subject ID | Time-point | Pandemic H1N1 HAI Titer | Seasonal H1N1 HAI Titer | CD4+ (cells/mm3) | Days on ART | Copies HIV DNA/million PBMC | Plasma RNA (copies/mL) | # HIV DNA Seq. | Divergence median (95% CI) | Diversity median (95% CI) | # Mono-typic sequences | % Mono-typic |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1
|
Entry
|
5
|
5
|
140
|
125
|
358
|
112
|
20
|
.080 (.047 to 113)
|
.052 (.007 to .097)
|
2
|
10
|
Week 3
|
20
|
5
| – |
206
|
38.4
|
36
|
.08 (.060 to .100)
|
.056 (.019 to .093)
|
10
|
28
| ||
2
|
Entry
|
10
|
10
|
337
|
77
|
22
|
ND
|
18
|
.023 (.020 to .027)
|
.032 (.019 to .045)
|
3
|
17
|
Week 3
|
20
|
10
| – |
17
|
ND
|
23
|
.017 (.014 to .023)
|
.026 (.014 to .038)
|
7
|
30
| ||
3
|
Entry
|
10
|
10
|
475
|
386
a
|
398
|
NA
|
21
|
.029 (.018 to .040)
|
.029 (.012 to .046)
|
2
|
10
|
Week 3
|
10
|
5
| – |
614
|
NA
|
19
|
.029 (.010 to .048)
|
.034 (.012 to .056)
|
4
|
21
| ||
4
|
Entry
|
5
|
10
|
623
|
882
a
|
123
|
NA
|
21
|
.019 (.009 to .029)
|
.020 (−.001 to .041)
|
10
|
48
|
Week 3
|
80
|
10
| – |
157
|
NA
|
20
|
.020 (.009 to .031)
|
.019 (.006 to .032)
|
6
|
30
| ||
5
|
Entry
|
5
|
40
|
1383
|
57
|
3
|
NA
|
22
|
.024 (.022 to .026)
|
.019 (.009 to .029)
|
10
|
45
|
Week 3
|
160
|
20
| – |
10
|
NA
|
20
|
.024 (.017 to .031)
|
.019 (.010 to .028)
|
8
|
40
| ||
6
|
Entry
|
40
|
40
|
400
|
302
a
|
24
|
<8
|
28
|
.017 (.006 to .028)
|
.017 ( to .003.037)
|
7
|
25
|
Week 3
|
320
|
40
| – |
6
|
ND
|
24
|
.017 (.007 to .027)
|
.02 (.003 to .037)
|
8
|
33
| ||
7
|
Entry
|
80
|
40
|
608
|
2494
a
|
70
|
ND
|
19
|
.016 (.010 to .022)
|
.015 (.004 to .026)
|
7
|
37
|
Week 3
|
160
|
40
| – |
3
|
ND
|
20
|
.016 (.013 to .019)
|
.015 (.007 to .023)
|
6
|
30
| ||
8
|
Entry
|
20
| 20 |
381
|
106
|
52
|
11.4
| 24 |
.054 (.023 to .085)
|
.037 (.004 to .070)
|
8
|
33
|
Week 3
|
160
|
20
| – |
57
|
<8
|
23
|
.052 (.034 to .070)
|
.042 (.010 to .074)
|
6
|
26
| ||
9
|
Entry
|
20
|
40
|
501
|
56
|
122
|
ND
|
21
|
.045 (.013 to .077)
|
.045 (.020 to .070)
|
8
|
40
|
Week 3
|
160
|
20
| – |
186
|
ND
|
20
|
.049 (.027 to .071)
|
.043 (.019 to .067)
|
8
|
40
| ||
10
|
Entry
|
80
|
20
|
712
|
85
|
153
|
NA
|
20
|
.050 (.016 to .084)
|
.059 (.022 to .096)
|
5
|
25
|
Week 3
|
1280
|
20
| – |
26
|
NA
|
24
|
.052 (.018 to .086)
|
.064 (.027 to .101)
|
4
|
17
|