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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 3/2017

27.08.2016

H2S Prevents Cyclosporine A-Induced Vasomotor Alteration in Rats

verfasst von: Na-na Ping, Yan-ni Mi, Dong-zheng Liu, Sai Zhang, Jing-guo Chen, Yong-xiao Cao

Erschienen in: Cardiovascular Toxicology | Ausgabe 3/2017

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Abstract

Cyclosporine A (CsA) induces hypertension after transplantation. Hydrogen sulfide (H2S) was found to have hypotensive/vasoprotective effects in the cardiovascular system. The present study aims to investigate the role of H2S on CsA-induced vascular function disorder in rats. Rats were subcutaneously injected with CsA 25 mg/kg for 21 days. Blood pressure was measured by the tail-cuff method. Vasomotion was determined using a sensitive myograph. Western blotting and immunohistochemistry were used to quantify the protein expression of endothelin type A (ETA) receptor and essential MAPK pathway molecules. Vascular superoxide anion production and serum contents of malondialdehyde were determined. The results showed that sodium hydrosulfide (NaHS), a H2S donor, significantly attenuated the increase of blood pressure and contractile responses, and the upregulation of ETA receptor induced by CsA. In addition, NaHS could restore the CsA decreased acetylcholine-induced vasodilatation. Furthermore, NaHS blocked the CsA-induced elevation of reactive oxygen species level, extracellular signal-regulated kinase and p38 MAPK activities. In conclusion, H2S prevents CsA-induced vasomotor dysfunction. H2S attenuates CsA-induced ETA receptor upregulation, which may be associated with MAPK signal pathways. H2S ameliorates endothelial-dependent relaxation, which may be through antioxidant activity.
Literatur
1.
Kovarik, J. M., & Burtin, P. (2003). Immunosuppressants in advanced clinical development for organ transplantation and selected autoimmune diseases. Expert Opinion on Emerging Drugs, 8, 47–62.CrossRefPubMed
2.
El-Mas, M. M., Helmy, M. W., Ali, R. M., & El-Gowelli, H. M. (2015). Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: Role of endothelin signaling. Toxicology and Applied Pharmacology, 284, 1–7.CrossRefPubMed
3.
Cao, L., Cao, Y. X., Xu, C. B., & Edvinsson, L. (2013). Altered endothelin receptor expression and affinity in spontaneously hypertensive rat cerebral and coronary arteries. PLoS One, 8, e73761.CrossRefPubMedPubMedCentral
4.
Li, J., Cao, Y. X., Liu, H., & Xu, C. B. (2007). Enhanced G-protein coupled receptors-mediated contraction and reduced endothelium-dependent relaxation in hypertension. European Journal of Pharmacology, 557, 186–194.CrossRefPubMed
5.
Agapitov, A. V., & Haynes, W. G. (2002). Role of endothelin in cardiovascular disease. Journal of the Renin-Angiotensin-Aldosterone System, 3, 1–15.CrossRefPubMed
6.
Ahnstedt, H., Stenman, E., Cao, L., Henriksson, M., & Edvinsson, L. (2012). Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture. Acta Physiologica (Oxf), 205, 266–278.CrossRef
7.
Takeda, Y., Miyamori, I., Yoneda, T., & Takeda, R. (1993). Increased concentration of endothelin messenger RNA in the mesenteric arteries of cyclosporine-induced hypertensive rats. American Journal of Hypertension, 6, 427–430.CrossRefPubMed
8.
Cao, L., Xu, C. B., Zhang, Y., Cao, Y. X., & Edvinsson, L. (2011). Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors. BMC Neuroscience, 12, 109.CrossRefPubMedPubMedCentral
9.
Nishiyama, A., Kobori, H., Fukui, T., Zhang, G. X., Yao, L., Rahman, M., et al. (2003). Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension. Hypertension, 42, 754–760.CrossRefPubMedPubMedCentral
10.
Ciarcia, R., Damiano, S., Florio, A., Spagnuolo, M., Zacchia, E., Squillacioti, C., et al. (2015). The protective effect of apocynin on cyclosporine A-induced hypertension and nephrotoxicity in rats. Journal of Cellular Biochemistry, 116, 1848–1856.CrossRefPubMed
11.
Liu, Y. H., Lu, M., Hu, L. F., Wong, P. T., Webb, G. D., & Bian, J. S. (2012). Hydrogen sulfide in the mammalian cardiovascular system. Antioxidants and Redox Signaling, 17, 141–185.CrossRefPubMed
12.
Olas, B. (2015). Hydrogen sulfide in signaling pathways. Clinica Chimica Acta, 439, 212–218.CrossRef
13.
14.
Al-Magableh, M. R., Kemp-Harper, B. K., & Hart, J. L. (2015). Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 38, 13–20.CrossRef
15.
Bianca, R. D. D., Mitidieri, E., Donnarumma, E., Tramontano, T., Brancaleone, V., Cirino, G., et al. (2015). Hydrogen sulfide is involved in dexamethasone-induced hypertension in rat. Nitric Oxide Biology Chemistry, 46, 80–86.CrossRef
16.
Zhang, P., Li, F., Wiegman, C. H., Zhang, M., Hong, Y., Gong, J., et al. (2015). Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology, 52, 129–137.CrossRefPubMed
17.
Li, X. H., Du, J. B., Bu, D. F., Tang, X. Y., & Tang, C. S. (2006). Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Acta Pharmacologica Sinica, 27, 971–980.CrossRefPubMed
18.
Rehman, H., Krishnasamy, Y., Haque, K., Thurman, R. G., Lemasters, J. J., Schnellmann, R. G., et al. (2014). Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats. PLoS One, 8, e65029.CrossRefPubMed
19.
Ping, N. N., Cao, L., Xiao, X., Li, S., & Cao, Y. X. (2014). The determination of optimal initial tension in rat coronary artery using wire myography. Physiological Research/Academia Scientiarum Bohemoslovaca, 63, 143–146.
20.
Cao, L., Zhang, Y., Cao, Y. X., Edvinsson, L., & Xu, C. B. (2012). Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS One, 7, e33008.CrossRefPubMedPubMedCentral
21.
He, X., Zhao, M., Bi, X. Y., Yu, X. J., & Zang, W. J. (2013). Delayed preconditioning prevents ischemia/reperfusion-induced endothelial injury in rats: Role of ROS and eNOS. Laboratory Investigation, 93, 168–180.CrossRefPubMed
22.
Virdis, A., Colucci, R., Versari, D., Ghisu, N., Fornai, M., Antonioli, L., et al. (2009). Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: Role of cyclooxygenase 2-derived contracting prostanoids. Hypertension, 53, 1008–1016.CrossRefPubMed
23.
Hansen-Schwartz, J., & Edvinsson, L. (2000). Increased sensitivity to ET-1 in rat cerebral arteries following organ culture. NeuroReport, 11, 649–652.CrossRefPubMed
24.
Roullet, J. B., Xue, H., McCarron, D. A., Holcomb, S., & Bennett, W. M. (1994). Vascular mechanisms of cyclosporin-induced hypertension in the rat. Journal of Clinical Investigation, 93, 2244–2250.CrossRefPubMedPubMedCentral
25.
Cheng, Y., Ndisang, J. F., Tang, G., Cao, K., & Wang, R. (2004). Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. American Journal of Physiology Heart and Circulatory Physiology, 287, H2316–H2323.CrossRefPubMed
26.
Yan, H., Du, J. B., & Tang, C. S. (2004). The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochemical and Biophysical Research Communications, 313, 22–27.CrossRefPubMed
27.
Al-Magableh, M. R., Kemp-Harper, B. K., & Hart, J. L. (2015). Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice. Hypertension Research, 38, 13–20.CrossRefPubMed
28.
Yang, G., & Wang, R. (2015). H2S and blood vessels: An overview. Handbook of Experimental Pharmacology, 230, 85–110.CrossRefPubMed
29.
Fleming I (2016) The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling. Vascular Pharmacology.
30.
Feletou, M., & Vanhoutte, P. M. (2009). EDHF: An update. Clinical Science (Lond), 117, 139–155.CrossRef
31.
Cauduro, R. L., Costa, C., Lhulier, F., Garcia, R. G., Cabral, R. D., Goncalves, L. F. S., et al. (2005). Endothelin-1 plasma levels and hypertension in cyclosporine-treated renal transplant patients. Clinical Transplants, 19, 470–474.CrossRef
32.
Bartholomeusz, B., Hardy, K. J., Nelson, A. S., & Phillips, P. A. (1996). Bosentan ameliorates cyclosporin A-induced hypertension in rats and primates. Hypertension, 27, 1341–1345.CrossRefPubMed
33.
Zheng, J. P., Zhang, X., Wang, H., Wang, Y., Cheng, Z., Yin, P., et al. (2013). Vasomotor dysfunction in the mesenteric artery after organ culture with cyclosporin A. Basic and Clinical Pharmacology and Toxicology, 113, 370–376.CrossRefPubMed
34.
Cao, L., Zhang, Y. P., Cao, Y. X., Edvinsson, L., & Xu, C. B. (2012). Cigarette smoke upregulates rat coronary artery endothelin receptors in vivo. PLoS One, 7, e33008.CrossRefPubMedPubMedCentral
35.
Zheng, J. P., Cheng, Z., Jiang, J., Ke, Y., & Liu, Z. (2015). Cyclosporin A upregulates ETB receptor in vascular smooth muscle via activation of mitogen-activating protein kinases and NF-kappaB pathways. Toxicology Letters, 235, 1–7.CrossRefPubMed
36.
Li, H. B., Qin, D. N., Cheng, K., Su, Q., Miao, Y. W., Guo, J., et al. (2015). Central blockade of salusin beta attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats. Scientific Reports, 5, 11162.CrossRefPubMedPubMedCentral
37.
Al-Magableh, M. R., Kemp-Harper, B. K., Ng, H. H., Miller, A. A., & Hart, J. L. (2014). Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro. Naunyn-Schmiedebergs Archives of Pharmacology, 387, 67–74.CrossRef
Metadaten
Titel
H2S Prevents Cyclosporine A-Induced Vasomotor Alteration in Rats
verfasst von
Na-na Ping
Yan-ni Mi
Dong-zheng Liu
Sai Zhang
Jing-guo Chen
Yong-xiao Cao
Publikationsdatum
27.08.2016
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 3/2017
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-016-9383-x

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