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Current Pulmonology Reports

Erschienen in:

04.05.2020 | Environmental and Occupational Health (S Cherian, Section Editor)

Hard Metal Lung Disease: Update in Diagnosis and Management

verfasst von: Matthew Zheng, Robert M. Marron, Sameep Sehgal

Erschienen in: Current Pulmonology Reports | Ausgabe 2/2020

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Abstract

Purpose of Review

Hard metal lung disease is a rare entity due to cobalt and tungsten carbide exposure. This review summarizes the literature focusing on pathogenesis, clinical features, diagnosis, and management.

Recent Findings

Theories for pathogenesis include immunogenic activation, oxidant injury, and induction of hypoxia-inducible factor in macrophages. Multinucleated giant cells with bizarre cannibalistic features are the most common pathological finding; however, it is not pathognomonic. Corticosteroids remain the mainstay of treatment based on data from small studies.

Summary

Hard metal lung disease exposure can lead to an occupational asthma or parenchymal lung disease, potentially leading to respiratory failure. A history of exposure and clinical findings along with appropriate radiographic and pathological findings are essential to establish a diagnosis. Treatment options include exposure cessation, corticosteroids, immunosuppressive therapies, and lung transplantation.

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Titel: Hard Metal Lung Disease: Update in Diagnosis and Management
verfasst von: Matthew Zheng
Robert M. Marron
Sameep Sehgal
Publikationsdatum: 04.05.2020
Verlag: Springer US
Erschienen in: Current Pulmonology Reports / Ausgabe 2/2020
Elektronische ISSN: 2199-2428
DOI: https://doi.org/10.1007/s13665-020-00247-x

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

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