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Cancer Causes & Control

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01.07.2010 | Original paper

Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children’s Oncology Group study

verfasst von: Saira Khan, Alison A. Evans, Lucy Rorke-Adams, Manuela A. Orjuela, Tania Shiminski-Maher, Greta R. Bunin

Erschienen in: Cancer Causes & Control | Ausgabe 7/2010

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Abstract

Objective

A comprehensive case–control study was conducted to determine potential risk factors for medulloblastoma/primitive neuroectodermal tumor (PNET), a common brain tumor in children. This analysis evaluated possible associations between previous head injury and ionizing radiation exposure through diagnostic X-rays and medulloblastoma/PNET.

Methods

Mothers of 318 cases <6 years of age at diagnosis between 1991 and 1997 and registered with the Children’s Oncology Group were interviewed. Mothers of 318 matching controls were selected through random digit dialing and interviewed.

Results

An association was not detected between previous head injury (OR: 0.78, 95% CI: 0.40–1.5) or head X-ray for any reason including head injury with medulloblastoma/PNET. A statistically non-significant excess of cases reported having an X-ray for reason other than head injury (OR 2.3, 95% CI 0.91–5.7). When cases that received an X-ray for a common symptom of medulloblastoma/PNET were considered unexposed this association weakened (OR: 1.3, 95% CI: 0.49–3.7). No dose–response relationship was observed.

Conclusions

Head injury and exposure to diagnostic head X-rays were not associated with medulloblastoma/PNET in this study. Future studies should investigate all imaging procedures with ionizing radiation exposure including computed tomography scans and utilize radiation dose estimations.

US Cancer Statistics Working Group (2005) United States Cancer Statistics: 2002 incidence and mortality. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Cancer Institute, Atlanta, GA

Pomeroy SL, Tamayo P, Gaasenbeek M et al (2002) Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415:436–462CrossRefPubMed

Surveillance, Epidemiology, and End Results (SEER) Program (2004) Public-use data (1973–2001). Cancer Statistics Branch, Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD

Gurney JG, Smith MA, Bunin GR (1999) CNS and miscellaneous intracranial and intraspinal neoplasms. In: Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, Bunin GR (eds) Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER Program, Bethesda, MD, pp 51–63

Ron E, Modan B, Boice JD et al (1988) Tumors of the brain and central nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039PubMed

National Institute of Environmental Health Sciences (2004) Report on Carcinogens, 11th edn. US Department of Health and Human Services, Public Health Service, National Toxicology Program

Stewart A, Webb J, Hewitt D (1958) A survey of childhood malignancies. Br Med J 1:1495–1508CrossRefPubMed

Harvey EB, Boice JD, Honeyman M, Flannery JT (1985) Prenatal X-ray exposure and childhood cancer in twins. N Engl J Med 312:541–545PubMedCrossRef

Bunin GR, Robison LL, Biegel JA, Pollack IF, Rorke-Adams LB (2006) Parental heat exposure and risk of childhood brain tumor: a Children’s Oncology Group study. Am J Epidemiol 164:222–231CrossRefPubMed

10.

Schuz J, Kaletsch U, Kaatsch P, Meinert R, Michaelis J (2000) Risk factors for pediatric tumors of the central nervous system: results from a German population-bases case-control study. Med Pediatr Oncol 36:274–282CrossRef

11.

Gurney JG, Preston-Martin S, McDaniel AM, Mueller BA, Holly EA (1996) Head injury as a risk factor for brain tumors in children: results from a multicenter case-control study. Epidemiology 7:485–489CrossRefPubMed

12.

Preston-Martin S, Mack W, Henderson BE (1989) Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res 49:6137–6143PubMed

13.

Preston-Martin S, Yu MC, Benton B, Henderson BE (1982) N-nitroso compounds and childhood brain tumors: a case-control study. Cancer Res 42:5240–5245PubMed

14.

Inskip PD, Mellemkjaer L, Gridley G, Olsen JH (2004) Incidence of intracranial tumors following hospitalization for head injuries (Denmark). Cancer Causes Control 9:109–116CrossRef

15.

Preston-Martin S, Pogoda JM, Schlehofer B et al (1998) An international case-control study of adult glioma and meningioma: the role of head trauma. Int J Epidemiol 27:579–586CrossRefPubMed

16.

Nyrgen C, Adami J, Weimin Y et al (2001) Primary brain tumors following traumatic brain injury: a population-based cohort study in Sweden. Cancer Causes Control 12:733–737CrossRef

17.

Bunin GR, Buckley JD, Boesel CP, Rorke LB, Meadows AT (1994) Risk factors for astrocytic glima and primitive neuroectodermal tumor of the brain in young children: a report from the Children’s Cancer Group. Caner Epidemiol Biomarkers Prev 3:197–204

18.

Howe GR, Burch JD, Chiarelli AM, Risch A, Choi BCK (1989) An exploratory case-control study of brain tumors in children. Cancer Res 49:4349–4352PubMed

19.

Hammer GP, Seidenbusch MC, Schneider K et al (2009) A cohort study of childhood incidence after postnatal diagnostic X-ray exposure. Radiat Res 171:504–512CrossRefPubMed

20.

Halperin EC, Watson DM, George SL (2001) Duration of symptoms prior to diagnosis is related to inversely presenting disease stage in children with medulloblastoma. Cancer 91:1444–1450CrossRefPubMed

21.

National Cancer Institute (2009) Pediatric CT Scans. Available at: http://dceg.cancer.gov/reb/research/ionizing/medical/4. Accessed on 13 October 2009

22.

Linton OW, Mettler FA (2003) National conference on dose reduction in CT, with an emphasis on pediatric patients. Am J Roentgenol 181:321–329

23.

Linet MS, Kim KP, Rajaraman P (2009) Children’s exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric considerations. Pediatric Radiol 39:S4–S26CrossRef

24.

West SL, Strom BL, Poole C (2005) Validity of pharmacoepidemiologic drug and diagnosis data. In: Strom BL (ed) Pharmacoepidemiology, 4th edn. Wiley, Chichester, pp 709–765

25.

Gama H, Correia S, Lunet N (2009) Questionnaire design and the recall of pharmacological treatments: a systematic review. Pharmacoepidemiol Drug Saf 18:175–187CrossRefPubMed

Titel: Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children’s Oncology Group study
verfasst von: Saira Khan
Alison A. Evans
Lucy Rorke-Adams
Manuela A. Orjuela
Tania Shiminski-Maher
Greta R. Bunin
Publikationsdatum: 01.07.2010
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9529-2

Springer Medizin

Head injury, diagnostic X-rays, and risk of medulloblastoma and primitive neuroectodermal tumor: a Children’s Oncology Group study