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Erschienen in: Osteoporosis International 11/2019

08.08.2019 | Short Communication

Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank

verfasst von: A. Zhou, H. A. Morris, E. Hyppönen

Erschienen in: Osteoporosis International | Ausgabe 11/2019

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Abstract

Summary

We conducted a phenome-wide Mendelian randomization analysis (MR-PheWAS) to survey health effects associated with high normal serum calcium. We found causal evidence for conditions related to renal function, bone and joint health, and cardiovascular risk. These conditions collectively suggest that tissue calcification may be a key mechanism through which serum calcium influences health.

Introduction

Calcium is essential for the normal functioning of the cardiovascular system, muscles, and nerves. In this MR-PheWAS study, we sought to capture the totality of health effects associated with high normal serum calcium.

Methods

We used data from up to 337,535 UK Biobank participants, and tested for associations between calcium genetic score (calcium-GS) and 925 disease outcomes, with follow-up analyses using complementary MR methods.

Results

Calcium-GS was robustly associated with serum calcium concentration (F statistics = 349). After multiple testing correction (P < 1.62E-4), we saw genetic evidence for an association between high serum calcium and urinary calculus (OR per 1 mg/dl 3.5, 95%CI 1.3–9.2), renal colic (9.1, 95%CI 2.5–33.5), and allergy/adverse effect of penicillin (2.2, 95%CI 1.5–3.3). Secondary analyses with independent replication from consortia meta-analyses suggested further effects on myocardial infarction and osteoarthrosis.

Conclusion

We found causal evidence for effects of high normal serum calcium with conditions related to renal function, bone and joint health, and cardiovascular risk, which may collectively reflect influences on tissue calcification and immune function.
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Metadaten
Titel
Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank
verfasst von
A. Zhou
H. A. Morris
E. Hyppönen
Publikationsdatum
08.08.2019
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 11/2019
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-019-05118-z

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