Health-resource use and quality of life in children with bronchiectasis: a multi-center pilot cohort study

Bronchiectasis is a chronic pulmonary disorder characterized by persistent wet or productive cough, recurrent exacerbations and abnormal dilatation of bronchial airways [1]. The prevalence in children is highest in low-income countries and Indigenous populations [2, 3], and the adverse impact on the child and carer’s quality of life (QoL) is increasingly recognised [4].

Illnesses that consume extensive health resources attract the attention of policy makers and funders [5]. Consequently, the European Multicentre Bronchiectasis Audit and Research Collaboration has recently identified healthcare utilisation as a research priority [6]. However, in children with bronchiectasis few studies describe its impact upon individuals and healthcare services. The limited published data from Australia and New Zealand are derived from hospital cohort studies [7, 8] or clinical trials [9], which cannot be generalized to out-patient or community settings. While in New Zealand the estimated cost of pediatric bronchiectasis hospitalizations was NZD 0.95 million in the 2012/13 financial year [8], there are no similar published Australian data on healthcare service utilization or costs related to bronchiectasis.

Thus, with the aim of informing government healthcare services and future research, our primary objective was to estimate healthcare resource use over a 12-month period for children aged < 18-years with bronchiectasis receiving ongoing care in pediatric respiratory medical centers. Our secondary objective was to measure and correlate the health-related QoL of parents/carers and children with bronchiectasis.

Here, we described the annual health resource use and parent/carer and child QoL scores in children with bronchiectasis managed at two Australian and one New Zealand hospitals. In this cohort, children averaged three exacerbations per annum. In any given month, approximately one-third of the cohort presented for medical care, half used antibiotics and one-quarter had absences from school or childcare. Parents/carers sought medical care from a specialist more frequently than GPs or EDs, except during exacerbations. While exacerbations were more frequent in winter, seasonal frequency of exacerbation-related resource use varied between types of resource use. Eleven-percent of exacerbations resulted in hospitalization, and in one-third this included subsequent “hospital-in-the-home” care. Although over time QoL scores for both parents/carers and children were high and stable, better QoL was significantly associated with low cough severity.

There are limited published Australian or New Zealand data on health-related resource use in children or adults with bronchiectasis with which to compare our findings. Redding et al. [15] reported that among Indigenous Australian and Alaskan children aged < 8-years, 15% of exacerbations resulted in hospitalization, which is similar to the findings of this study [15]. In the general Australian child population GP attendance was 3.8 visits/year per child between 2012 and 2015 [16], with acute respiratory illness (ARI) the most common reason for presentation. In a cohort of urban Indigenous children aged < 5-years, health service utilisation for ARI was 3.6 visits per child-year [17] with an annual mean cost in 2017 Australian dollars of $991 (95% confidence interval 514–1468) per child [18]. Thus children with bronchiectasis are seeking health care as frequently as young children with common ARIs and, given the predominance of specialist reviews and hospitalizations, the annual cost of bronchiectasis in children is likely to be substantially higher.

Antibiotic use is high in this cohort, although some may be associated with long-term maintenance courses, such as with azithromycin, rather than additional prescriptions for new exacerbations each month. Nevertheless, the prescription rate of 46.0 per 100 child-months (or 552 per 100 child-years) in this cohort is much higher than the antibiotic prescription rate of 41.4 per 100 child-years that was reported for all Australian children aged 0–12 years in 2013 [19]. Of all Australian children dispensed antibiotics for systemic use in 2013, 53% received one systemic antibiotic course, 22% received two, 11% had three and the remainder received four or more. In New Zealand, during 2010–2014, the mean number of antibiotic courses dispensed to children aged < 6-years approximated 190 per 100 child-years, with dispensing rates 29–35% higher among Maori/Pacific Islanders compared to New Zealand European children [20]. The higher frequency of antibiotic use among exacerbations during winter that was identified in this study is consistent with overall trends of antibiotics prescribing to Australian children in primary care settings [21].

In any given month, one-quarter of the children in the cohort missed school or childcare due to their bronchiectasis. In a recent study of Alaskan Native children aged 7–17 years with bronchiectasis, 15/34 missed school in the previous 12-months because of respiratory illnesses [22]. A systematic review of social and economic consequences of childhood asthma [23] reported children with asthma were absent from school for 2.1–14.8 days per year. This compares with an average 12-days per child-year in our study. Chronic school absenteeism is associated with suboptimal school achievement [24], which can lead to long-term social and economic disadvantage. Children with chronic illness often demonstrate worse school outcomes than their peers without chronic illness [25]. Furthermore, parents/carers frequently take time from work to care for their child, resulting in lost productivity and income.

The overall high QoL and low cough scores we observed are not surprising given that they were obtained during routine clinical visits, as found in another Brisbane study reporting similar QoL scores for children in a stable state [7]. Our finding that both PC-QoL and CC-QoL scores were negatively associated with cough severity is consistent with PC-QoL significantly declining during exacerbations [7].

This study has several limitations. As all symptom and resource use data were parent-reported and data were collected on a monthly basis, there is a potential for parent/guardian misclassification and recall bias respectively. Future studies could reduce the risk of recall bias, and improve the accuracy of findings, by using medical records to confirm parent-reported data and/or having more frequent follow-up. With respect to the representativeness of the study sample; the differences in baseline characteristics between those participants who completed all monthly follow-ups, and those that did not, suggest that younger children and children with poor birth outcomes were over-represented among the data obtained. Redding et al. [15] reported that among Indigenous children with bronchiectasis, younger children (aged < 3-years) were more likely to be hospitalized than older children. Poor birth outcomes are recognized risk factors for respiratory disease [26] and it is plausible that poor birth outcomes may be associated with higher resource use as a result of earlier and more severe respiratory disease.

The study was conducted in three centers where quarterly clinical reviews are standard care and where the relationship between clinicians and their patients is such that families have ongoing access to advice and support when needed. Hence our findings may apply only to centers with similar practices. Furthermore, whilst the clinical characteristics of our children are similar to other bronchiectasis studies conducted in the same study centres [9], the study findings may not be generalisable to children with bronchiectasis elsewhere [27, 28] given reported differences in clinical presentations and underlying etiology. Nevertheless, as shown in Table 3, the attendance at scheduled visits following enrolment was only about 50% for reasons that are uncertain. It may reflect visits that were scheduled when the child was well and the parent/carer did not consider attendance necessary and/or the competing demands of families with respect to work and school, a concern reported by New Zealand mothers of children with bronchiectasis [29]. The small number of parents/carers and children who completed QoL and cough severity questionnaires is likely to have biased our findings, particularly as most questionnaires were completed at clinic visits. It is plausible that the QoL of parents/carers and children who regularly attend scheduled visits and receive ongoing specialist care may be better than those who do not [30]. Alternatively, those not attending may have milder disease. Finally, the tool used to measure cough severity has been reported to have some limitations with respect to its correlation with cough frequency. However there are few other validated tools for assessing cough severity in children [31] and this tool has been used repeatedly in other paediatric respiratory studies, enabling comparisons to be made between studies [32‐34].

To our knowledge, this study is the first to provide disease burden estimates by measuring healthcare resource use for managing pediatric bronchiectasis. It suggests resource use is substantial. Further research is needed to more precisely estimate the cost of disease to families, the healthcare sector and third parties in a broader population of children with bronchiectasis. Such data are critical for informing policy and designing and evaluating interventions to reduce the burden of disease.