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01.12.2015 | Research Article

High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Valosin-containing protein (VCP) is one of the AAA-ATPase superfamily members. The correlation between elevated expression of VCP and progression, prognosis, and the metastatic potential has been identified in various tumor types. However, the clinical impact of VCP in breast carcinoma has not been investigated. In the current study, the expression of VCP in 421 breast tumors and adjacent normal breast tissues was examined to investigate the correlation between VCP expression and clinicopathological features in patients with breast carcinoma. We found that the expression of VCP correlated with the TNM stage, Ki67 labeling, and lymph node metastasis (LNM). The expression of VCP was increased significantly in the cytoplasm of cancer cells compared to normal mammary epithelial cells, which was associated with decreased overall survival rates of patients with breast carcinoma (P < 0.001). In conclusion, this study demonstrates significant correlation between the cytoplasmic expression of VCP and adverse prognosis in breast carcinoma, suggesting that VCP may serve as a prognostic biomarker in breast carcinoma.

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Titel: High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma
Publikationsdatum: 01.12.2015
Erschienen in: Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-3748-9

Springer Medizin

High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma

Abstract

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Springer Medizin

Abstract

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