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Erschienen in: Breast Cancer Research 5/2008

01.10.2008 | Viewpoint

Highway to heaven: mammary gland development and differentiation

verfasst von: Lorenzo Melchor, Matthew J Smalley

Erschienen in: Breast Cancer Research | Ausgabe 5/2008

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Abstract

In recent years, the mammary gland epithelium has been shown to be a mixture of differentiated cell populations in a hierarchical relationship with their stem and progenitor cells. However, the mechanisms that regulate their cellular differentiation processes are still unclear. The identification of genes that govern stem and progenitor cell expansion, or that determine daughter cell fate, will be of crucial interest for understanding breast cancer diversity and, ultimately, improving treatment. Two recent analyses have identified some of the key genes that regulate these processes, lighting up the highway to normal mammary gland development.
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Metadaten
Titel
Highway to heaven: mammary gland development and differentiation
verfasst von
Lorenzo Melchor
Matthew J Smalley
Publikationsdatum
01.10.2008
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2008
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2147

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