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Tumor Biology
Erschienen in: Tumor Biology 12/2015

01.12.2015 | Research Article

Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling

verfasst von: Shun Li, Xiao Liu, Xiangrong Chen, Liu Zhang, Xiangyu Wang

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Histone deacetylases (HDACs) play a role in the tumorigenesis of glioblastoma multiforme (GBM), whereas the underlying mechanism has not been elucidated. Here, we reported significantly higher HDAC6 levels in GBM from the patients. GBM cell growth was significantly inhibited by ACY-1215, a specific HDAC6 inhibitor. Further analyses show that HDAC6 may promote growth of GBM cells through inhibition of SMAD2 phosphorylation to downregulate p21. Thus, our data demonstrate a previously unrecognized regulation pathway in that HDAC6 increases GBM growth through attenuating transforming growth factor β (TGFβ) receptor signaling.
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Metadaten
Titel
Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling
verfasst von
Shun Li
Xiao Liu
Xiangrong Chen
Liu Zhang
Xiangyu Wang
Publikationsdatum
01.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3747-x

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