Skip to main content
Erschienen in: International Urogynecology Journal 8/2014

01.08.2014 | Original Article

How antepartum and postpartum acute urinary retention affects the function and structure of the rat bladder

verfasst von: Ching-Chung Liang, Yi-Hao Lin, Tse-Ching Chen, Shuenn-Dhy Chang

Erschienen in: International Urogynecology Journal | Ausgabe 8/2014

Einloggen, um Zugang zu erhalten

Abstract

Introduction and hypothesis

To examine the effect of acute urinary retention (AUR) on the urodynamic function and molecular structure of rat bladders in pregnancy and after parturition.

Methods

Forty-eight nulliparous rats were distributed into AUR and non-AUR groups. AUR was induced by clamping the distal urethra of each rat after infusing 3 ml of saline for 60 min. Plasma progesterone levels and cystometric data were evaluated on the 14th day of gestation, 3 and 10 days postpartum, and in virgin rats. The immunoreactivity of caveolins and nerve growth factor (NGF) was analyzed. The number of caveolae in bladder muscle cells was evaluated by electron microscopy.

Results

Progesterone levels significantly increased during pregnancy and 3 days postpartum. In cystometric results, the AUR group has significantly shorter intercontraction interval, lower void volume and greater residual volume compared with the non-AUR. AUR rats exhibited higher NGF immunoreactivity, lower caveolin-1 immunoreactivity, and less caveolae in the bladder compared with the non-AUR. The caveolin-1 and NGF immunoreactivity and the number of caveolae in the bladder decreased during pregnancy and 3 days postpartum compared with virgin rats. By using Pearson correlations, we found significant correlations between urodynamic variables (residual volumes and intercontraction intervals) and the expressions of caveolin-1, caveolae and NGF in the AUR rats on the 14th day of gestation and 3 days postpartum.

Conclusions

Bladder dysfunction in pregnancy and immediately postpartum in a rat model caused by AUR is associated with the plasma progesterone level change and the expressions of caveolin, caveolae, and NGF in bladder muscle cells.
Literatur
1.
Zurück zum Zitat Saultz JW, Toffer WL, Sbackles JY (1991) Postpartum urinary retention. J Am Board Fam Pract 4:341–344PubMed Saultz JW, Toffer WL, Sbackles JY (1991) Postpartum urinary retention. J Am Board Fam Pract 4:341–344PubMed
2.
Zurück zum Zitat Hinman F (1976) Postoperative overdistension of the bladder. Surg Gynecol Obstet 142:901–902PubMed Hinman F (1976) Postoperative overdistension of the bladder. Surg Gynecol Obstet 142:901–902PubMed
3.
Zurück zum Zitat Saito M, Miyagawa I (2001) Bladder dysfunction after acute urinary retention in rats. J Urol 165:1745–1747PubMedCrossRef Saito M, Miyagawa I (2001) Bladder dysfunction after acute urinary retention in rats. J Urol 165:1745–1747PubMedCrossRef
4.
Zurück zum Zitat Shimizu S, Saito M, Kinoshita Y et al (2009) Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free radical scavenger. BJU Int 104:713–717PubMedCrossRef Shimizu S, Saito M, Kinoshita Y et al (2009) Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free radical scavenger. BJU Int 104:713–717PubMedCrossRef
5.
Zurück zum Zitat Liang CC, Wong SY, Tsay PK et al (2002) The effect of epidural analgesia on postpartum urinary retention in women who deliver vaginally. Int J Obstet Anesth 11:164–169PubMedCrossRef Liang CC, Wong SY, Tsay PK et al (2002) The effect of epidural analgesia on postpartum urinary retention in women who deliver vaginally. Int J Obstet Anesth 11:164–169PubMedCrossRef
6.
Zurück zum Zitat Muellner RS (1939) Physiological bladder changes during pregnancy and the puerperium. J Urol 41:691–695 Muellner RS (1939) Physiological bladder changes during pregnancy and the puerperium. J Urol 41:691–695
7.
Zurück zum Zitat Groutz A, Blaivas JG, Chaikin DC (2000) Bladder outlet obstruction in women: definition and characteristics. Neurourol Urodyn 19:213–220PubMedCrossRef Groutz A, Blaivas JG, Chaikin DC (2000) Bladder outlet obstruction in women: definition and characteristics. Neurourol Urodyn 19:213–220PubMedCrossRef
8.
Zurück zum Zitat Shinbo H, Kurita Y, Takada S et al (2010) Resistive index as risk factor for acute urinary retention in patients with benign prostatic hyperplasia. Urology 76:1440–1445PubMedCrossRef Shinbo H, Kurita Y, Takada S et al (2010) Resistive index as risk factor for acute urinary retention in patients with benign prostatic hyperplasia. Urology 76:1440–1445PubMedCrossRef
9.
Zurück zum Zitat Steers WD, Kolbeck S, Creedon D, Tuttle JB (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709–1715PubMedCentralPubMedCrossRef Steers WD, Kolbeck S, Creedon D, Tuttle JB (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709–1715PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Polyak E, Boopathi E, Mohanan S et al (2009) Alterations in caveolin expression and ultrastructure after bladder smooth muscle hypertrophy. J Urol 182:2497–2503PubMedCrossRef Polyak E, Boopathi E, Mohanan S et al (2009) Alterations in caveolin expression and ultrastructure after bladder smooth muscle hypertrophy. J Urol 182:2497–2503PubMedCrossRef
11.
Zurück zum Zitat Saito M, Shimizu S, Kinoshita Y et al (2010) Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model. Mol Cell Biochem 333:109–114PubMedCrossRef Saito M, Shimizu S, Kinoshita Y et al (2010) Bladder dysfunction after acute urinary retention in the rats: a novel over active bladder model. Mol Cell Biochem 333:109–114PubMedCrossRef
12.
Zurück zum Zitat Lin YH, Liu G, Kavran M et al (2008) Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis. BJU Int 102:1724–1730PubMedCrossRef Lin YH, Liu G, Kavran M et al (2008) Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis. BJU Int 102:1724–1730PubMedCrossRef
13.
Zurück zum Zitat Bakircioglu ME, Sievert KD, Lau A, Lin CS, Lue TF (2000) The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra. BJU Int 85:350–361PubMedCrossRef Bakircioglu ME, Sievert KD, Lau A, Lin CS, Lue TF (2000) The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra. BJU Int 85:350–361PubMedCrossRef
14.
Zurück zum Zitat Tammela TL, Levin RM, Monson FC, Wein AJ, Longhurst PA (1993) The influence of acute overdistension on rat bladder function and DNA synthesis. J Urol 150:1533–1539PubMed Tammela TL, Levin RM, Monson FC, Wein AJ, Longhurst PA (1993) The influence of acute overdistension on rat bladder function and DNA synthesis. J Urol 150:1533–1539PubMed
15.
Zurück zum Zitat Severs NJ (1988) Caveolae: static inpocketings of the plasma membrane, dynamic vesicles or pain artifact? J Cell Sci 90:341–348PubMed Severs NJ (1988) Caveolae: static inpocketings of the plasma membrane, dynamic vesicles or pain artifact? J Cell Sci 90:341–348PubMed
16.
Zurück zum Zitat Cristofaro V, Peters CA, Yalla SV, Sullivan MP (2007) Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions. Neurourol Urodyn 26:71–80PubMedCrossRef Cristofaro V, Peters CA, Yalla SV, Sullivan MP (2007) Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions. Neurourol Urodyn 26:71–80PubMedCrossRef
17.
Zurück zum Zitat Elbadawi A, Yalla SV, Resnick NM (1993) Structural basis of geriatric voiding dysfunction. IV. Bladder outlet obstruction. J Urol 150:1681–1695PubMed Elbadawi A, Yalla SV, Resnick NM (1993) Structural basis of geriatric voiding dysfunction. IV. Bladder outlet obstruction. J Urol 150:1681–1695PubMed
18.
Zurück zum Zitat Hnasko R, Lisanti MP (2003) The biology of caveolae: lessons from caveolin knockout mice and implications for human disease. Mol Interv 3:445–464PubMedCrossRef Hnasko R, Lisanti MP (2003) The biology of caveolae: lessons from caveolin knockout mice and implications for human disease. Mol Interv 3:445–464PubMedCrossRef
19.
Zurück zum Zitat Li S, Couet J, Lisanti MP (1996) Src tyrosine kinases, G alpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem 271:29182–29190PubMedCrossRef Li S, Couet J, Lisanti MP (1996) Src tyrosine kinases, G alpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem 271:29182–29190PubMedCrossRef
20.
Zurück zum Zitat Koleske AJ, Baltimore D, Lisanti MP (1995) Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci U S A 92:1381–1385PubMedCentralPubMedCrossRef Koleske AJ, Baltimore D, Lisanti MP (1995) Reduction of caveolin and caveolae in oncogenically transformed cells. Proc Natl Acad Sci U S A 92:1381–1385PubMedCentralPubMedCrossRef
21.
Zurück zum Zitat Kogo H, Ito SY, Moritoki Y, Kurahashi H, Fujimoto T (2006) Differential expression of caveolin-3 in mouse smooth muscle cells in vivo. Cell Tissue Res 324:291–300PubMedCrossRef Kogo H, Ito SY, Moritoki Y, Kurahashi H, Fujimoto T (2006) Differential expression of caveolin-3 in mouse smooth muscle cells in vivo. Cell Tissue Res 324:291–300PubMedCrossRef
22.
Zurück zum Zitat Sievert KD, Bakircioglu ME, Tsai T, Dahms SE, Nunes L, Lue TF (2001) The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part 1: Functional and structural change. J Urol 166:311–317PubMedCrossRef Sievert KD, Bakircioglu ME, Tsai T, Dahms SE, Nunes L, Lue TF (2001) The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part 1: Functional and structural change. J Urol 166:311–317PubMedCrossRef
23.
Zurück zum Zitat Swift SE, Ostergard DR (1993) Effects of progesterone on the urinary tract. Int Urogynecol J 4:232–236CrossRef Swift SE, Ostergard DR (1993) Effects of progesterone on the urinary tract. Int Urogynecol J 4:232–236CrossRef
24.
Zurück zum Zitat Elliot RA, Castleden CM (1994) Effect of progestogens and oestrogens on the contractile response of rat detrusor muscle to electrical field stimulation. Clin Sci (Lond) 87:337–342 Elliot RA, Castleden CM (1994) Effect of progestogens and oestrogens on the contractile response of rat detrusor muscle to electrical field stimulation. Clin Sci (Lond) 87:337–342
Metadaten
Titel
How antepartum and postpartum acute urinary retention affects the function and structure of the rat bladder
verfasst von
Ching-Chung Liang
Yi-Hao Lin
Tse-Ching Chen
Shuenn-Dhy Chang
Publikationsdatum
01.08.2014
Verlag
Springer London
Erschienen in
International Urogynecology Journal / Ausgabe 8/2014
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-013-2320-7

Weitere Artikel der Ausgabe 8/2014

International Urogynecology Journal 8/2014 Zur Ausgabe

Ambulantisierung: Erste Erfahrungen mit dem Hybrid-DRG

02.05.2024 DCK 2024 Kongressbericht

Die Hybrid-DRG-Verordnung soll dazu führen, dass mehr chirurgische Eingriffe ambulant durchgeführt werden, wie es in anderen Ländern schon länger üblich ist. Die gleiche Vergütung im ambulanten und stationären Sektor hatten Niedergelassene schon lange gefordert. Aber die Umsetzung bereitet ihnen doch Kopfzerbrechen.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Harninkontinenz: Netz-Op. erfordert über lange Zeit intensive Nachsorge

30.04.2024 Harninkontinenz Nachrichten

Frauen mit Belastungsinkontinenz oder Organprolaps sind nach einer Netz-Operation keineswegs beschwerdefrei. Vielmehr scheint die Krankheitslast weiterhin hoch zu sein, sogar höher als von harninkontinenten Frauen, die sich nicht haben operieren lassen.

Welche Übungen helfen gegen Diastase recti abdominis?

30.04.2024 Schwangerenvorsorge Nachrichten

Die Autorinnen und Autoren einer aktuellen Studie aus Griechenland sind sich einig, dass Bewegungstherapie, einschließlich Übungen zur Stärkung der Bauchmuskulatur und zur Stabilisierung des Rumpfes, eine Diastase recti abdominis postpartum wirksam reduzieren kann. Doch vieles ist noch nicht eindeutig belegt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.