Erschienen in:
01.09.2012 | Commentaries
Human In Vitro Models of Ischaemic Stroke: a Test Bed for Translation
verfasst von:
Ana Antonic, Emily S. Sena, Geoffrey A. Donnan, David W. Howells
Erschienen in:
Translational Stroke Research
|
Ausgabe 3/2012
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Excerpt
Our increased understanding of the ischaemic cascade has driven the rush to develop neuroprotective interventions. Over 500 have been reported to effectively improve outcome in experimental animal models of stroke. Although a number of well-conducted clinical trials have been performed, we have failed to reproduce these effects in humans [
1]. Despite these difficulties in translation, neuroprotection remains an important potential therapy. If safe and easily administered, potentially in a pre-hospital setting, even small absolute benefits might have a significant impact. …