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01.05.2010 | Original paper

Human papillomavirus is not associated with colorectal cancer in a large international study

verfasst von: Michele C. Gornick, Xavier Castellsague, Gloria Sanchez, Thomas J. Giordano, Michelle Vinco, Joel K. Greenson, Gabriel Capella, Leon Raskin, Gad Rennert, Stephen B. Gruber, Victor Moreno

Erschienen in: Cancer Causes & Control | Ausgabe 5/2010

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Abstract

Objective of the study

Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.

Methods

The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).

Results

All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.

Conclusions

We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

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Titel: Human papillomavirus is not associated with colorectal cancer in a large international study
verfasst von: Michele C. Gornick
Xavier Castellsague
Gloria Sanchez
Thomas J. Giordano
Michelle Vinco
Joel K. Greenson
Gabriel Capella
Leon Raskin
Gad Rennert
Stephen B. Gruber
Victor Moreno
Publikationsdatum: 01.05.2010
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 5/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9502-0

Springer Medizin

Human papillomavirus is not associated with colorectal cancer in a large international study